Results 81 to 90 of about 18,795 (277)
Tachykinins Processing is Significantly Impaired in PC1 and PC2 Mutant Mouse Spinal Cord S9 Fractions [PDF]
, 2015 Substance P (SP) play a central role in nociceptive transmission and it is an agonist of the Neurokinin-1 receptor located in the lamina I of the spinal cord.
Beaudry, Francis +3 more
core +1 more source
Functional Regulation of Semaphorin Receptors by Proprotein Convertases [PDF]
Journal of Biological Chemistry, 2003 PLEXIN genes encode receptors for secreted and membrane-bound semaphorins. It was proposed that the extracellular domain of plexins acts as an inhibitory moiety, preventing receptor activation. Here we show that plexin-B1 and plexin-B2 undergo proteolytic processing in their extracellular portion, thereby converting single-chain precursors into non ...
ARTIGIANI, Stefania +7 more
openaire +5 more sources
Molecular Metabolism, 2022 Objective: The hypothalamus regulates feeding and glucose homeostasis through the balanced action of different neuropeptides, which are cleaved and activated by the proprotein convertases PC1/3 and PC2. However, the recent association of polymorphisms in
Ilaria Coppola +7 more
doaj
Frontiers in Endocrinology, 2013 This Prohormone Theory was simultaneously proposed in 1967 by two independent groups using two different approaches and two experimental models. Donald Steiner, in elegant pulse-chase experiments, proposed the existence of proinsulin when he observed ...
Michel eChretien
doaj +1 more source
The proprotein convertase furin is required for trophoblast syncytialization [PDF]
Cell Death & Disease, 2013 The multinucleated syncytial trophoblast, which forms the outermost layer of the placenta and serves multiple functions, is differentiated from and maintained by cytotrophoblast cell fusion. Deficiencies in syncytial trophoblast differentiation or maintenance likely contribute to intrauterine growth restriction and pre-eclampsia, two common gestational
Zhi Zhou +8 more
openaire +3 more sources
Mapping Hsp104 interactions using cross‐linking mass spectrometry
FEBS Open Bio, EarlyView.This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal +3 more
wiley +1 more source
Cell Reports, 2018 Summary: Furin trafficking, and that of related proprotein convertases (PCs), may regulate which substrates are accessible for endoproteolysis, but tools to directly test this hypothesis have been lacking.
Pierpaolo Ginefra +4 more
doaj +1 more source
Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency. [PDF]
, 2013 Non-synonymous mutations affecting both alleles of PCSK1 (proprotein convertase 1/3) are associated with obesity and impaired prohormone processing. We report a proband who was compound heterozygous for a maternally inherited frameshift mutation and a ...
Bochukova, Elena +8 more
core +3 more sources
Advanced Science, EarlyView.By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley +1 more source
Extracellular Processing of Lysyl Oxidase-like 2 and Its Effect on Amine Oxidase Activity [PDF]
, 2018 This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biochemistry, copyright © American Chemical Society after peer review and technical editing by the publisher.
Finney, Joel +4 more
core +2 more sources