The Non-Evaginated Secondary Prosencephalon of Vertebrates [PDF]
Frontiers in Neuroanatomy, 2011 The secondary prosencephalon (telencephalon plus hypothalamus) is probably the most complex area of the brain, with complicated patterning specifications.
Nerea Moreno, Agustín González
exaly +5 more sources
Holoprosencephaly: Review of Embryology, Clinical Phenotypes, Etiology and Management [PDF]
Children, 2023 Holoprosencephaly (HPE) is the most common malformation of the prosencephalon in humans. It is characterized by a continuum of structural brain anomalies resulting from the failure of midline cleavage of the prosencephalon.
Maísa Malta +3 more
doaj +2 more sources
Antenatal and Postnatal Diagnosis of Semilobar Holoprosencephaly: Two Case Reports [PDF]
Global Pediatric Health, 2023 Holoprosencephaly (HPE) is a rare birth defect that occurs during the first few weeks of pregnancy. It results from a disturbance in the usual signaling pathways required for separation of the embryonic prosencephalon into 2 separate cerebral hemispheres.
Benmoussa Meryem +5 more
doaj +2 more sources
Maternal diabetes disrupts early corticogenesis through altered mitotic gene regulation: a transcriptomic analysis [PDF]
Frontiers in EndocrinologyMaternal diabetes is linked to neurodevelopmental impairments in offspring, but the underlying molecular mechanisms remain unclear. Early cortical neurogenesis is a critical window vulnerable to maternal metabolic disturbances.
Rocío Valle-Bautista +5 more
doaj +2 more sources
Semilobar Holoprosencephaly Caused by a Novel and De Novo ZIC2 Pathogenic Variant [PDF]
Balkan Journal of Medical Genetics, 2022 Holoprosencephaly (HPE) is the most common embryonic forebrain developmental anomaly. It involves incomplete or absent division of the prosencephalon into two distinct cerebral hemispheres during the early stages of organogenesis.
Nonkulovski D +5 more
doaj +2 more sources
Case Report: Hypodipsic hypernatremia secondary to hydrocephalus in a dog [PDF]
Frontiers in Veterinary ScienceA 6-year-old male castrated golden retriever was presented for inappetence, lethargy, and progressive obtundation. A chemistry panel showed hypernatremia (>190 mmol/L) and hyperchloremia (157 mmol/L).
Maddisen W. Antes +2 more
doaj +2 more sources
Multi-neuromeric origin of tyrosine hydroxylase-positive neurons within the substantia nigra and ventral tegmental area [PDF]
Frontiers in NeuroanatomyDuring early developmental stages, the brain is divided into three primary regions: the forebrain (prosencephalon), the hindbrain (rhombencephalon), and the spinal cord.
José L. Ferran +13 more
doaj +2 more sources
EARLY-ONSET CENTRAL DIABETES INSIPIDUS IN A NEWBORN WITH HOLOPROSENCEPHALY
İstanbul Tıp Fakültesi Dergisi, 2021 Holoprosencephaly is a complex brain malformation caused by the inability of the prosencephalon to divide to form the cerebral hemispheres. Central diabetes insipidus (CDI), as a result of a defect in vasopressin release, may be seen due to the abnormal ...
Mustafa Törehan Aslan +2 more
doaj +1 more source
Cyclopia with proboscis: A rare congenital anomaly
Clinical Case Reports, 2021 Cyclopia with a proboscis, a rare congenital anomaly, and a severe form of holoprosencephaly occur as a result of incomplete separation of prosencephalon into two halves of hemispheres during organogenesis.
Asma Kunwar +4 more
doaj +1 more source
Semilobarholoprosencephaly – A Dreading Congenital Anomaly [PDF]
Journal of Clinical and Diagnostic Research, 2017 Holoprosencephaly (HPE) is a group of structural abnormalities of brain that is an important cause of childhood mortality and morbidity. They usually occur due to impaired midline cleavage of embryonic forebrain i.e., failure of differentiation of the ...
Bhushita B Lakhkar +2 more
doaj +1 more source