Results 151 to 160 of about 311,944 (266)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

KAN-PROSPECT: a Kolmogorov-Arnold Networks-integrated framework for predicting the effects and adverse reactions of natural products via transfer learning. [PDF]

Sci Rep
Du Z, Wang Z, Chen Y, Li B, Wan X, Ren T, Chen H, Liu L, Jin Q, Zhang Y, Zhang Y, Bai J, Xie H, Chen X, Ren X, Zhang D.   +15 more
europepmc   +1 more source

Prospect Avenue in Bradentown

, 1900
Prospect Avenue in ...

core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Assessment of the PROSPECT safety systems including socio-economic evaluation [Elektronisk resurs]

, 2018
This report provides a new methodology for safety benefit assessment of real-world benefit of the Advanced Driver Assistance Systems (ADAS) in terms of saved lives and prevented injuries as well as the resulting monetary benefit for society.
Stoll, Johann,, Bálint, András,, Jaussein, Marie,, Schneider, Anja,, Bräutigam, Julia,, Petersson, Mats,, Perlet, Klaus,, Breunig, Sandra,, Kovaceva, Jordanka,, Puente Guillen, Pablo,, Large, David,, Schindler, Ron,   +11 more
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Machine learning surrogate for the leaf PROSPECT-D model and its applications across plant species. [PDF]

Sci Rep
Rahimi-Majd M, Xu R, Bauermeister S, Nikoloski Z.   +3 more
europepmc   +1 more source

Bank Risk-Taking in a Prospect Theory Framework Empirical Investigation in the Emerging Markets’ Case [PDF]

The purpose of this paper is to investigate the validity of some behavioral conjectures as alternative explanations of bank risk-taking behavior. We especially focus on the different valuation of gains and losses relative to a reference point, and the ...
Christophe Godlewski
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Pain management strategies following thoracic surgery: best practices and innovations. [PDF]

J Thorac Dis
Sylvester CB, Groth SS.
europepmc   +1 more source