Results 21 to 30 of about 1,617,665 (246)

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis, Okeleji Olayinka, Mariam Z. Quraishi, Lakshmi V. Srivaths, Deborah L. Brown, Neethu M. Menon, Ricardo A. Mosquera, Ashwin P. Patel, James M. Stark, Aravind Yadav   +9 more
wiley   +1 more source

The role of the early-life gut microbiome in childhood asthma

Gut Microbes
Asthma is a chronic disease affecting millions of children worldwide, and in severe cases requires hospitalization. The etiology of asthma is multifactorial, caused by both genetic and environmental factors.
Ulrika Boulund, Jonathan Thorsen, Urvish Trivedi, Kaare Tranæs, Jie Jiang, Shiraz A. Shah, Jakob Stokholm   +6 more
doaj   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial

Nature Communications, 2020
Here, the authors present the results of a mother–child cohort randomized clinical trial of n-3 LCPUFA and vitamin D maternal supplementation, finding an association between supplement-induced microbiota changes in infant airways at age 1-month but not ...
Mathis H. Hjelmsø, Shiraz A. Shah, Jonathan Thorsen, Morten Rasmussen, Gisle Vestergaard, Martin S. Mortensen, Asker Brejnrod, Susanne Brix, Bo Chawes, Klaus Bønnelykke, Søren J. Sørensen, Jakob Stokholm, Hans Bisgaard   +12 more
doaj   +1 more source

Exposures to perfluoroalkyl substances and asthma phenotypes in childhood: an investigation of the COPSAC2010 cohortResearch in context

EBioMedicine, 2023
Summary: Background: Exposure to perfluoroalkyl substances may affect offspring immune development and thereby increase risk of childhood asthma, but the underlying mechanisms and asthma phenotype affected by such exposure is unknown.
Astrid Sevelsted, Casper-Emil Tingskov Pedersen, Gözde Gürdeniz, Morten Arendt Rasmussen, Jörg Schullehner, Kalliroi Sdougkou, Jonathan W. Martin, Jessica Lasky-Su, Andreanne Morin, Carole Ober, Ann-Marie Malby Schoos, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes, Hans Bisgaard   +14 more
doaj   +1 more source

Potential Early Risk Biomarkers for Reduced Forced Expiratory Volume in Children Post‐Hematopoietic Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We sought to identify potential early risk biomarkers for lung disease in children post‐allogeneic HCT. Patients with pulmonary function tests 3 months post‐transplant and plasma samples between days 7 and 14 post‐HCT were included. Six of 27 subjects enrolled had reduced forced expiratory volume 1 (FEV1) z scores.
Isabella S. Small, Pi Chun Cheng, April L. Rahrig, Courtney M. Rowan   +3 more
wiley   +1 more source

Design of the 18-year follow-up of the Danish COPSAC2000 birth cohort

BMJ Paediatrics Open
Background Atopic diseases, obesity and neuropsychiatric disorders are lifestyle-related and environmental-related chronic inflammatory disorders, and the incidences have increased in the last years.Objective To outline the design of the 18-year follow ...
Anne-Marie Nybo Andersen, Katrine Strandberg-Larsen, Jonathan Groot, Klaus Bønnelykke, Jakob Stokholm, Rebecca Vinding, Bo Chawes, Marianne Mikkelsen, Ann-Marie Malby Schoos, Nicklas Brustad, Trine Mølbæk-Engbjerg, Nilo Vahman, Nadia Rahman Fink, Emil Dalgaard Christensen, Lærke Sass, Hedda Løvenhøj   +15 more
doaj   +1 more source

Maturation of the gut microbiome and risk of asthma in childhood

Nature Communications, 2018
Colonization of commensal bacteria is thought to impact immune development, especially in the earliest years of life. Here, the authors show, by analyzing the development of the gut microbiome of 690 children, that microbial composition at the age of 1 ...
Jakob Stokholm, Martin J. Blaser, Jonathan Thorsen, Morten A. Rasmussen, Johannes Waage, Rebecca K. Vinding, Ann-Marie M. Schoos, Asja Kunøe, Nadia R. Fink, Bo L. Chawes, Klaus Bønnelykke, Asker D. Brejnrod, Martin S. Mortensen, Waleed Abu Al-Soud, Søren J. Sørensen, Hans Bisgaard   +15 more
doaj   +1 more source

L’épidémie de poliomyélite de 1948-1949 : chamanisme, force vitale et auto-sacrifice chez les Inuit du Kivalliq

Revue d'Études Autochtones, 2022
À l’automne 1948, une « maladie étrange » fait son apparition à Igluligaarjuk (Chesterfield Inlet), un petit village de la baie d’Hudson. Les Soeurs Grises en charge de l’hôpital sont les premières à sonner l’alerte.
Frédéric Laugrand
doaj   +1 more source

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source