Results 41 to 50 of about 2,763,456 (261)

Reduced IL-2 response from peripheral blood mononuclear cells exposed to bacteria at 6 months of age is associated with elevated total-IgE and allergic rhinitis during the first 7 years of lifeResearch in context

EBioMedicine, 2019
Background: Autoimmunity and allergy have been associated with decreased number and function of regulatory T-cells (Tregs) and low interleukin-2 (IL-2) levels. We aimed to investigate if the release of IL-2 from peripheral blood mononuclear cells (PBMCs)
Ni Wang, Ann-Marie M. Schoos, Jeppe M. Larsen, Susanne Brix, Anna H. Thysen, Morten A. Rasmussen, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Bo L. Chawes   +9 more
doaj   +1 more source

The Metabolomics of Childhood Atopic Diseases: A Comprehensive Pathway-Specific Review

Metabolites, 2020
Asthma, allergic rhinitis, food allergy, and atopic dermatitis are common childhood diseases with several different underlying mechanisms, i.e., endotypes of disease.
Mette S. Schjødt, Gözde Gürdeniz, Bo Chawes   +2 more
doaj   +1 more source

Exposures to perfluoroalkyl substances and asthma phenotypes in childhood: an investigation of the COPSAC2010 cohortResearch in context

EBioMedicine, 2023
Summary: Background: Exposure to perfluoroalkyl substances may affect offspring immune development and thereby increase risk of childhood asthma, but the underlying mechanisms and asthma phenotype affected by such exposure is unknown.
Astrid Sevelsted, Casper-Emil Tingskov Pedersen, Gözde Gürdeniz, Morten Arendt Rasmussen, Jörg Schullehner, Kalliroi Sdougkou, Jonathan W. Martin, Jessica Lasky-Su, Andreanne Morin, Carole Ober, Ann-Marie Malby Schoos, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes, Hans Bisgaard   +14 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Longitudinal metabolome profiling from pregnancy through childhood and risk of neurodevelopmental disorders at age 10

Nature Communications
Neurodevelopmental disorders (NDD) are characterized by impairments in brain development that affect motor and cognitive systems. Early identification of NDD risk factors is crucial for prevention.
Tingting Wang, Jens Richardt Møllegaard Jepsen, Rebecca Vinding, Nicklas Brustad, Liang Chen, María Hernández-Lorca, Mina Ali, Julie Bøjstrup Rosenberg, Parisa Mohammadzadeh, Michael Widdowson, Parvaneh Ebrahimi, Morten A. Rasmussen, Jonathan Thorsen, Klaus Bønnelykke, Bjørn H. Ebdrup, Bo Chawes   +15 more
doaj   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Prospective sur l'avenir du secteur semencier : répercussions pour la politique de l'INRA. Tome 2

, 1996
L'INRA a toujours accordé une importance majeure à la génétique et à l'amélioration des plantes, considérées comme des voies royales pour faire progresser l'agriculture.
Délégation Permanente À L'Agriculture, Au Développement Et À La Prospective, -
core   +1 more source

Collaborative overview ('meta-analysis') of prospective observational studies of the associations of usual blood pressure and usual cholesterol levels with common causes of death: protocol for the second cycle of the Prospective Studies Collaboration.

, 1999
BACKGROUND: Many prospective studies have been reported on the associations of blood pressure and blood cholesterol with cardiovascular disease, but few have been large enough to provide reliable estimates of the nature of these associations in different
Prospective Studies Collaboration
core   +2 more sources

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

A metabolomic signature of maternal BMI is associated with pregnancy complications across two independent pregnancy cohorts

Communications Medicine
Background Maternal obesity is increasingly common and linked to pregnancy complications, likely driven by underlying metabolic perturbations. This study investigates the association between maternal pre-pregnancy body mass index (BMI) and pregnancy ...
David Horner, Rebecca Vinding, Tingting Wang, Mina Ali, Mario Lovric, Nicole Prince, Jessica Lasky-Su, Klaus Bønnelykke, Jakob Stokholm, Bo Chawes, Morten Arendt Rasmussen   +10 more
doaj   +1 more source