Results 51 to 60 of about 1,617,665 (246)

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd, Melissa Taylor, Helen Fulbright, Bob Phillips   +3 more
wiley   +1 more source

Screen Time Is Associated With Cardiometabolic and Cardiovascular Disease Risk in Childhood and Adolescence

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Screen time in children and adolescents may be linked to cardiometabolic and cardiovascular risk. Methods We analyzed data from >1000 participants in the COPSAC2010 and COPSAC2000 (Copenhagen Prospective Studies on Asthma in Childhood) mother ...
David Horner, Marie Jahn, Klaus Bønnelykke, Bo Chawes, Trine Flensborg‐Madsen, Ann‐Marie Malby Schoos, Jakob Stokholm, Morten Arendt Rasmussen   +7 more
doaj   +1 more source

Genomic prospecting [PDF]

Nature Medicine, 1995
The importahce of preserving biodiversity extends beyond the discovery of new drugs to understanding how other species have dealt with medical problems we currently face.
openaire   +2 more sources

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Vulnerable Plaques: From PROSPECT to Prospects…

JACC: Cardiovascular Imaging, 2012
Modern cardiology can definitely pride itself for developing techniques designed to restore blood flow in coronary arteries with tight lesions that cause myocardial ischemia or in the aftermath of an acute myocardial infarction (MI).
Finn, Aloke V., Chandrashekhar, Y., Narula, Jagat   +2 more
openaire   +2 more sources

Characterizing Parental Concerns About Lasting Impacts of Treatment in Children With B‐Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker, Sarah W. Alexander, Lisa M. Jacola, Kimberly A. Buff, Kyobin Hwang, Elham Hashemi, Gregory Stoddard, Lindsay A. Jibb   +7 more
wiley   +1 more source

Neonatal Urine Metabolic Profiling and Development of Childhood Asthma

Metabolites, 2019
Urine metabolomics case-control studies of childhood asthma have demonstrated a discriminative ability. Here, we investigated whether urine metabolic profiles from healthy neonates were associated with the development of asthma in childhood.
Bo L. Chawes, Giuseppe Giordano, Paola Pirillo, Daniela Rago, Morten A. Rasmussen, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Eugenio Baraldi   +8 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Échanges commerciaux, vulnérabilité des termes de l’échange, croissance économique et corruption : Une analyse économétrique par le modéle ARDL au Sénégal [PDF]

Revue Hybrides, 2023
This article analyzes the impacts of vulnerability linked to the terms of trade of Senegal's trade balance, exchange rate fluctuations, gross domestic product per capita and corruption on the country's economic growth within the period 1990 to 2021.
DJIBRIL DIALLO
doaj