Results 31 to 40 of about 15,191,982 (262)

Regression dilution methods for meta-analysis: assessing long-term variability in plasma fibrinogen among 27 247 adults in 15 prospective studies

, 2006
BACKGROUND: Within-person variability in measured values of a risk factor can bias its association with disease. The extent of this regression dilution bias for plasma fibrinogen was investigated using repeat measurement data collected at varying time ...
Thompson, Simon G, Fibrinogen Studies Collaboration, Fibrinogen Studies Collaboration Group, Wood, Angela M, Lewington, Sarah, Salomaa V, Danesh, John, White, Ian   +7 more
core   +1 more source

High-dose vitamin D supplementation in pregnancy and 25(OH)D sufficiency in childhood reduce the risk of fractures and improve bone mineralization in childhood: Follow-up of a randomized clinical trial

EClinicalMedicine, 2022
Summary: Background: Exposure to vitamin D in early life has been associated with improved bone mineralization, but no studies have investigated the combined effect of pregnancy supplementation and childhood 25(OH)D concentrations on bone health ...
Nicklas Brustad, Bo L. Chawes, Jonathan Thorsen, Martin Krakauer, Jessica Lasky-Su, Scott T. Weiss, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard   +8 more
doaj   +1 more source

Design of the 18-year follow-up of the Danish COPSAC2000 birth cohort

BMJ Paediatrics Open
Background Atopic diseases, obesity and neuropsychiatric disorders are lifestyle-related and environmental-related chronic inflammatory disorders, and the incidences have increased in the last years.Objective To outline the design of the 18-year follow ...
Anne-Marie Nybo Andersen, Katrine Strandberg-Larsen, Jonathan Groot, Klaus Bønnelykke, Jakob Stokholm, Rebecca Vinding, Bo Chawes, Marianne Mikkelsen, Ann-Marie Malby Schoos, Nicklas Brustad, Trine Mølbæk-Engbjerg, Nilo Vahman, Nadia Rahman Fink, Emil Dalgaard Christensen, Lærke Sass, Hedda Løvenhøj   +15 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Infant gut anellovirus composition associates with early life factors and childhood atopic disease

Nature Communications
Anelloviruses are single-stranded circular DNA viruses that infect eukaryotic cells. They are acquired in infancy and can be found in most body compartments.
Ulrika Boulund, Jonathan Thorsen, Frej Larsen, Casper S. Poulsen, Michael Widdowson, Jie Jiang, Kaare Tranæs, Ling Deng, Morten Arendt Rasmussen, Bo Chawes, Klaus Bønnelykke, Dennis S. Nielsen, Shiraz A. Shah, Jakob Stokholm   +13 more
doaj   +1 more source

Maturation of the gut microbiome and risk of asthma in childhood

Nature Communications, 2018
Colonization of commensal bacteria is thought to impact immune development, especially in the earliest years of life. Here, the authors show, by analyzing the development of the gut microbiome of 690 children, that microbial composition at the age of 1 ...
Jakob Stokholm, Martin J. Blaser, Jonathan Thorsen, Morten A. Rasmussen, Johannes Waage, Rebecca K. Vinding, Ann-Marie M. Schoos, Asja Kunøe, Nadia R. Fink, Bo L. Chawes, Klaus Bønnelykke, Asker D. Brejnrod, Martin S. Mortensen, Waleed Abu Al-Soud, Søren J. Sørensen, Hans Bisgaard   +15 more
doaj   +1 more source

Delayed Motor Milestones Achievement in Infancy Associates with Perturbations of Amino Acids and Lipid Metabolic Pathways

Metabolites, 2020
The relationship between developmental milestone achievement in infancy and later cognitive function and mental health is well established, but underlying biochemical mechanisms are poorly described. Our study aims to discover pathways connected to motor
Rebecca Kofod Vinding, Daniela Rago, Rachel S. Kelly, Gözde Gürdeniz, Morten Arendt Rasmussen, Jakob Stokholm, Klaus Bønnelykke, Augusto A. Litonjua, Scott T. Weiss, Jessica Lasky-Su, Hans Bisgaard, Bo Lund Chawes   +11 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Infant airway microbiota and topical immune perturbations in the origins of childhood asthma

Nature Communications, 2019
Here, Thorsen et al. examine the microbiota during the first three months of life in a cohort of 700 children and find that microbial diversity and the relative abundances of Veillonella and Prevotella in the airways at one month of age are associated ...
Jonathan Thorsen, Morten A. Rasmussen, Johannes Waage, Martin Mortensen, Asker Brejnrod, Klaus Bønnelykke, Bo L. Chawes, Susanne Brix, Søren J. Sørensen, Jakob Stokholm, Hans Bisgaard   +10 more
doaj   +1 more source

Reduced IL-2 response from peripheral blood mononuclear cells exposed to bacteria at 6 months of age is associated with elevated total-IgE and allergic rhinitis during the first 7 years of lifeResearch in context

EBioMedicine, 2019
Background: Autoimmunity and allergy have been associated with decreased number and function of regulatory T-cells (Tregs) and low interleukin-2 (IL-2) levels. We aimed to investigate if the release of IL-2 from peripheral blood mononuclear cells (PBMCs)
Ni Wang, Ann-Marie M. Schoos, Jeppe M. Larsen, Susanne Brix, Anna H. Thysen, Morten A. Rasmussen, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Bo L. Chawes   +9 more
doaj   +1 more source