Results 31 to 40 of about 14,645,487 (296)

Maturation of the gut microbiome and risk of asthma in childhood

Nature Communications, 2018
Colonization of commensal bacteria is thought to impact immune development, especially in the earliest years of life. Here, the authors show, by analyzing the development of the gut microbiome of 690 children, that microbial composition at the age of 1 ...
Jakob Stokholm, Martin J. Blaser, Jonathan Thorsen, Morten A. Rasmussen, Johannes Waage, Rebecca K. Vinding, Ann-Marie M. Schoos, Asja Kunøe, Nadia R. Fink, Bo L. Chawes, Klaus Bønnelykke, Asker D. Brejnrod, Martin S. Mortensen, Waleed Abu Al-Soud, Søren J. Sørensen, Hans Bisgaard   +15 more
doaj   +1 more source

Delayed Motor Milestones Achievement in Infancy Associates with Perturbations of Amino Acids and Lipid Metabolic Pathways

Metabolites, 2020
The relationship between developmental milestone achievement in infancy and later cognitive function and mental health is well established, but underlying biochemical mechanisms are poorly described. Our study aims to discover pathways connected to motor
Rebecca Kofod Vinding, Daniela Rago, Rachel S. Kelly, Gözde Gürdeniz, Morten Arendt Rasmussen, Jakob Stokholm, Klaus Bønnelykke, Augusto A. Litonjua, Scott T. Weiss, Jessica Lasky-Su, Hans Bisgaard, Bo Lund Chawes   +11 more
doaj   +1 more source

Regression dilution methods for meta-analysis: assessing long-term variability in plasma fibrinogen among 27 247 adults in 15 prospective studies

, 2006
BACKGROUND: Within-person variability in measured values of a risk factor can bias its association with disease. The extent of this regression dilution bias for plasma fibrinogen was investigated using repeat measurement data collected at varying time ...
White, I, Thompson, Simon G, Fibrinogen Studies Collaboration, Fibrinogen Studies Collaboration Group, Wood, AM, Wood, Angela M, Thompson, SG, Lewington, Sarah, Danesh, J, Salomaa V, Danesh, John, White, Ian   +11 more
core   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Reduced IL-2 response from peripheral blood mononuclear cells exposed to bacteria at 6 months of age is associated with elevated total-IgE and allergic rhinitis during the first 7 years of lifeResearch in context

EBioMedicine, 2019
Background: Autoimmunity and allergy have been associated with decreased number and function of regulatory T-cells (Tregs) and low interleukin-2 (IL-2) levels. We aimed to investigate if the release of IL-2 from peripheral blood mononuclear cells (PBMCs)
Ni Wang, Ann-Marie M. Schoos, Jeppe M. Larsen, Susanne Brix, Anna H. Thysen, Morten A. Rasmussen, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Bo L. Chawes   +9 more
doaj   +1 more source

Acute Neurological Events in Children With Hemoglobin SC Disease: A Multicenter Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurological manifestations in children with hemoglobin SC (HbSC) disease remain insufficiently characterized, particularly regarding acute events. The aim of this study was to describe the spectrum and frequency of acute neurological events in a multicenter cohort of children with HbSC disease.
Célia Paulmin, Bérengère Koehl, Audrey Maudoux, Hanine Mansour, Marie‐Hélène Odievre, Nathalie Garrec, Emilie Georget, Cécile Arnaud, Slimane Allali, Lydia Doumdo, Marie Belloy, Corinne Guitton   +11 more
wiley   +1 more source

Longitudinal metabolome profiling from pregnancy through childhood and risk of neurodevelopmental disorders at age 10

Nature Communications
Neurodevelopmental disorders (NDD) are characterized by impairments in brain development that affect motor and cognitive systems. Early identification of NDD risk factors is crucial for prevention.
Tingting Wang, Jens Richardt Møllegaard Jepsen, Rebecca Vinding, Nicklas Brustad, Liang Chen, María Hernández-Lorca, Mina Ali, Julie Bøjstrup Rosenberg, Parisa Mohammadzadeh, Michael Widdowson, Parvaneh Ebrahimi, Morten A. Rasmussen, Jonathan Thorsen, Klaus Bønnelykke, Bjørn H. Ebdrup, Bo Chawes   +15 more
doaj   +1 more source

Infant airway microbiota and topical immune perturbations in the origins of childhood asthma

Nature Communications, 2019
Here, Thorsen et al. examine the microbiota during the first three months of life in a cohort of 700 children and find that microbial diversity and the relative abundances of Veillonella and Prevotella in the airways at one month of age are associated ...
Jonathan Thorsen, Morten A. Rasmussen, Johannes Waage, Martin Mortensen, Asker Brejnrod, Klaus Bønnelykke, Bo L. Chawes, Susanne Brix, Søren J. Sørensen, Jakob Stokholm, Hans Bisgaard   +10 more
doaj   +1 more source

Antibiotic exposure in infancy and development of BMI and body composition in childhood

EClinicalMedicine, 2019
Background: It has been hypothesized that antibiotic usage in early life could contribute to development of overweight in childhood. Studies have seen association between antibiotic usage and overweight in childhood.
Tobias Steen Sejersen, Rebecca Kofod Vinding, Jakob Stokholm, Bo Chawes, Klaus Bønnelykke, Martin Krakauer, Hans Bisgaard   +6 more
doaj   +1 more source

Prospective Study of Pyrexia with Pregnancy

Annals of African Medicine, 2023
Objectives: Fever in pregnancy is a common clinical problem that increases the risk of morbidity for the mother and fetus. We studied variable medical complications of pregnant women suffering from fever and possible fetal complications.
Mewada, Bhavana N., Gandhi, Dimple, Diwan, Farheen, Panchal, Paresh Naranbhai   +3 more
openaire   +2 more sources