Results 241 to 250 of about 4,001,481 (304)

Stiripentol: Unpublished results from the first phase 2 clinical trial in Lennox–Gastaut syndrome conducted in the early 1990s

open access: yesEpilepsia, EarlyView.
Abstract Objective This study was undertaken to present the results of an exploratory phase 2 trial of stiripentol in Lennox–Gastaut syndrome (LGS). Methods This exploratory single‐blind, single‐arm, nonrandomized sequential‐period phase 2 study was conducted at four centers in France between January 1989 and August 1993.
Stéphane Auvin   +3 more
wiley   +1 more source

Agreement and 2‐year trajectories of youth‐ and parent‐reported health‐related quality of life in youth with epilepsy treated with surgery vs medical therapy

open access: yesEpilepsia, EarlyView.
Abstract Objective This cohort study examined the agreement between youth‐ and parent‐reported health‐related quality of life (HRQOL) of children treated with epilepsy surgery compared to medical therapy. A second aim was to evaluate whether changes in HRQOL over 2 years differed between the two groups, and to determine whether these trajectories ...
Mary Lou Smith   +2 more
wiley   +1 more source

Recommendations for structural magnetic resonance imaging in infants with first afebrile seizure or new onset epilepsy: Evidence‐based recommendations from the ILAE Neuroimaging Task Force

open access: yesEpilepsia, EarlyView.
Abstract Infants aged 1–24 months with new onset epilepsy frequently present with structural brain abnormalities, yet no updated evidence‐based magnetic resonance imaging (MRI) guidelines exist for this population. The International League Against Epilepsy (ILAE) Neuroimaging Task Force developed evidence‐based recommendations for structural brain MRI ...
Gavin P. Winston   +15 more
wiley   +1 more source

Systematic statistical analysis of change in SEIzure interVAL with diazepam nasal spray supports this novel clinical endpoint for immediate‐use seizure medication

open access: yesEpilepsia, EarlyView.
Abstract Objective Appropriate endpoints for daily antiseizure medications may differ from those for intermittent, immediate‐use seizure medications (ISMs). The observed interval between seizure clusters over time (SEIzure interVAL [SEIVAL]) has been proposed as a novel effectiveness endpoint for ISMs.
Wesley T. Kerr   +4 more
wiley   +1 more source

The recruitment and retention of headteachers in Scotland: main report: [PDF]

open access: yes, 2009
Darleen, Opfer   +6 more
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