Results 181 to 190 of about 78,509 (319)

Microsomal Prostaglandin Synthase-1–Derived Prostaglandin E ₂ Protects Against Angiotensin II–Induced Hypertension via Inhibition of Oxidative Stress [PDF]

, 2008
Zhanjun Jia, Xiaohua Guo, Hui Zhang, Mong-Heng Wang, Zheng Dong, Tianxin Yang   +5 more
openalex   +1 more source

Effects of acute selective cyclooxygenase‐2 inhibition on skeletal muscle microvascular oxygenation and exercise tolerance

Experimental Physiology, EarlyView.
Abstract The cyclooxygenase (COX) pathway regulates vascular tone and, therefore, local O2 delivery‐utilization matching. The two main isoforms, COX‐1 and COX‐2, may promote opposing effects on contracting muscle O2 transport in health by inducing vasoconstriction and vasodilatation, respectively.
Michael D. Belbis, Michael J. Holmes, Joseph Yao, Christopher W. Kinnick, Christopher K. Kargl, Carly Day, Nicole L. Noel, Timothy P. Gavin, Bruno T. Roseguini, Daniel M. Hirai   +9 more
wiley   +1 more source

Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization. [PDF]

BMC Vet Res
Wang PC, Liu J, Liu YF, Wu Y, Xue LL, Yang ZS.   +5 more
europepmc   +1 more source

Synergistic Up-Regulation of Prostaglandin E Synthase Expression in Breast Cancer Cells by 17β-Estradiol and Proinflammatory Cytokines [PDF]

, 2008
Jonna Frasor, Aisha Weaver, Madhumita Pradhan, Kinnari Mehta   +3 more
openalex   +1 more source

Endothelial TRPV4–Cx43 signalling complex regulates vasomotor tone in resistance arteries

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we investigate, for the first time, the role of endothelial Cx43 hemichannels (hCx43) in the regulation of vasomotor tone. We discovered that TRPV4 channels and Cx43 are in proximity within the endothelium of mouse arterioles.
Pía C. Burboa, Pablo S. Gaete, Ping Shu, Priscila A. Araujo, Annie V. Beuve, Walter N. Durán, Jorge E. Contreras, Mauricio A. Lillo   +7 more
wiley   +1 more source

Excessive hypercholesterolaemia during pregnancy as a risk factor for endothelial dysfunction in pre‐eclampsia

The Journal of Physiology, EarlyView.
Abstract figure legend Excessive hypercholesterolaemia during pregnancy impairs maternal endothelial function, which, in turn, drives the development of pre‐eclampsia and may also contribute to the increased risk of later‐life cardiovascular disease in women.
Amanda A. de Oliveira, Floor Spaans, Christy‐Lynn M. Cooke, Sandra T. Davidge   +3 more
wiley   +1 more source

Spatiotemporal characterization of cyclooxygenase pathway enzymes during vertebrate embryonic development. [PDF]

Dev Biol
Leathers TA, Ramarapu R, Rogers CD.
europepmc   +1 more source

Toward the Discovery of New Agents Able to Inhibit the Expression of Microsomal Prostaglandin E Synthase‐1 Enzyme as Promising Tools in Drug Development [PDF]

, 2010
Rosa De Simone, Rosa Andres Ejarque, Maurizio Aquino, Ines Bruno, María Dolores Chamorro Guerrero, María Carmen Terencio, Miguel Payá, Raffaele Riccio   +7 more
openalex   +1 more source

Cellular Senescence in Cancer: Mechanisms, Roles in Tumor Progression, and Therapeutic Implications

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Senescent tumor cells in TME exhibit dual roles. “Angels” secrete SASPs/DAMPs to boost immunological clearance and antitumor immunity via MHC‐I upregulation; “Demons” produce tumor‐promoting SASPs recruiting MDSCs to drive malignancy. ABSTRACT Cellular senescence, a state of irreversible cell cycle arrest accompanied by a senescence‐associated ...
Jingrui Yan, Yu Zhang, Guohua Mao, Jun Yu, Tianxing Zhou, Jihui Hao   +5 more
wiley   +1 more source

Prostaglandins limit nuclear actin rod formation during <i>Drosophila</i> oogenesis. [PDF]

MicroPubl Biol
Tootle TL.
europepmc   +1 more source