Results 171 to 180 of about 9,035 (267)

Heterologous Expression and In Vivo Functional Analysis of OsTPS2 in Yeast, Tobacco, and Rice. [PDF]

Plants (Basel)
Li H, Li S, Zhang X, Luo Y.
europepmc   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Characterization of a new specific mPGES-1 inhibitor in cardiovascular system. [PDF]

Sci Rep
Lin X, Feng H, Zhang JR, Gurusamy M, Nasseri S, Pekcec A, Wu D.   +6 more
europepmc   +1 more source

Microsomal Prostaglandin E Synthase-1 in Respiratory Diseases

Microsomal prostaglandin E synthase-1 [mPGES-1] is today a well recognized target for the development of nextgeneration anti-inflammatory drugs with improved selectivity and safety compared to nonsteroidal anti-inflammatory drugs [NSAIDs]. mPGES-1 is a terminal prostaglandin E2 [PGE2] synthase in the cyclooxygenase pathway.
openaire   +1 more source

Impact of Varying Soybean Oil Concentrations on the Cytokine Profile of Skeletal Muscle and Liver of Pigs: A Systems Biology Approach

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Lipids are important for metabolic processes, mainly cytokine regulation in the skeletal muscle and liver. Considering the soybean oil concentration, a weighted gene co‐expression network analysis (WGCNA) was used to perform an integrative analysis in skeletal muscle and liver tissues.
Fernanda Nery Ciconello, Julia Dezen Gomes, Simara Larissa Fanalli, Bárbara Silva‐Vignato, Andrezza Maria Felício‐Ament, Vivian Vezzoni de Almeida, Cristina Tchorny Moncau‐Gadbem, James Eugene Koltes, Christopher Keith Tuggle, Aline Silva Mello Cesar   +9 more
wiley   +1 more source

Integrative machine learning and network toxicology framework for assessing environmental pollutant TCDD-induced osteoarthritis risk: a computational cheminformatics approach. [PDF]

Front Pharmacol
Li L, Zhang Y, Qiu W, Li X, Ji J, Cao L, Lü J, Zhu X, Su Z.   +8 more
europepmc   +1 more source

Analysis of Two New Flavonoid Glycosides From Zanha golungensis Hiern With COX Inhibition Activity: Structural Elucidation, DFT Calculations, In Vitro and Molecular Docking Assessment

Analytical Science Advances, Volume 7, Issue 1, June 2026.
Zanha golungensis contains phenolic compounds amongst which are two previously undescribed flavonoid glycosides as shown in this study. The constituents of this plant exhibit anti‐inflammatory activity by inhibiting cyclooxygenases (COX‐1 and COX‐2).
Jean Zeuikena, Romeo Toko Feunaing, Alfred Ngenge Tamfu, Abel Joel Yaya Gbaweng, Celine Henoumont, Sophie Laurent, El Hassane Anouar, Emmanuel Talla   +7 more
wiley   +1 more source

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

Brain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh, Mark Morris, Paraskevi Goggolidou, Sree Chaithanya, Marcus Abbawy, Amelia Wild, Prashant Nasa, Niharika A. Duggal, Fang Gao‐Smith, Zubair Ahmed, Suresh Renukappa, Tonny Veenith   +14 more
wiley   +1 more source

Naproxen and Ibuprofen Exposure Alter the Blood-Testis Barrier in a Novel In Vitro Model. [PDF]

Int J Mol Sci
Crow KMS, Cho IK, Edenfield RC, Easley KF, Planinić A, Younis N, Waters E, McClellan JS, Zielen AC, Tager K, Castro C, Simerly C, Orwig KE, Ježek D, Koval M, Easley CA.   +15 more
europepmc   +1 more source

Traditional Respiratory Remedies From Anatolia: Ethnobotanical Insights and Bioactive Properties

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
ABSTRACT Respiratory disorders, ranging from acute viral infections such as influenza and bronchitis to chronic inflammatory conditions including chronic obstructive pulmonary disease, asthma, emphysema, and pneumonia, represent a major global health burden, affecting millions annually. Traditional Anatolian folk medicine has long relied on plant‐based
Golshan Zare, Yağmur Diker, Irem Tatlı Çankaya, Emran Habibi, Satyajit D. Sarker, Lutfun Nahar   +5 more
wiley   +1 more source