Results 181 to 190 of about 9,035 (267)

The role of <i>OLE2</i> and <i>POX1-3</i> in prostaglandin E₂ production and virulence is conserved in <i>Candidozyma</i> (<i>Candida</i>) <i>auris</i>. [PDF]

Microbiol Spectr
Bolsenbroek A, Bisschoff E, Kemp G, Sebolai O, Pohl C, Albertyn J.   +5 more
europepmc   +1 more source

Structure and function of microsomal prostaglandin E synthase-1

, 2010
The glutathione-dependent enzyme microsomal prostaglandin E synthase-1 (MPGES1) plays a pivotal role in inflammatory diseases. MPGES1 is up-regulated by pro-inflammatory cytokines in concert with cyclooxygenase (COX) -2, and the concerted action of both enzymes leads to the production of induced prostaglandin E2 (PGE2), a potent lipid mediator of ...
openaire   +1 more source

Phytochemical Profiling, Antiplatelet Potential, and Cytotoxic Assessment of Thymelaea tartonraira Aerial Part Essential Oil: In Vitro and In Silico Studies

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
Essential oil from Thymelaea tartonraira was characterized by GC–MS and evaluated using in vitro and in silico approaches. The oil exhibited notable antiplatelet activity with low cytotoxicity. Molecular docking revealed strong interactions of major compounds with GPVI, COX‐1, and P2Y12, supporting its potential as a natural antiplatelet agent ...
Siwar Soltani, Asma Haffouz, Imed Koubaa, Ali Gargouri, Amira Jerbi, Ikram Ben Amor, Jalel Gargouri, Basma HadjKacem, Noureddine Allouche   +8 more
wiley   +1 more source

In vitro expression of genes encoding HIF1α, VEGFA, PGE2 synthases, and PGE2 receptors in feline oral squamous cell carcinoma. [PDF]

J Vet Diagn Invest
Nasry WHS, Rodriguez-Lecompte JC, Martin CK.   +2 more
europepmc   +1 more source

The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objectives Oral dysbiosis can accelerate the progression of head and neck squamous cell carcinoma (HNSCC) by fostering a pro‐inflammatory, immunosuppressive, and metabolically altered environment. This narrative review examines the relationships between periodontitis‐associated bacteria and HNSCC, focusing on their impact on oncogenic pathways,
Yashmin Afshar, Nima Rezaei
wiley   +1 more source

Liquid Chromatography-Tandem Mass Spectrometry-Based Targeted Lipidomic Analysis of Obesity-Related Colorectal Cancer: Potential Roles of the CYP Eicosanoid Pathway. [PDF]

J Nutr
Lei L, Jing N, Xie M, Zhang J, Hammock BD, Yang J, Zhang G.   +6 more
europepmc   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

Stimulation of Transient Receptor Potential Channels TRPM3 and TRPM8 Increases Human Prostaglandin Endoperoxide Synthase-2 Promoter Activity. [PDF]

Molecules
Brandmeier N, Rössler OG, Thiel G.
europepmc   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

A phase 2 trial investigating the efficacy and safety of the mPGES-1 inhibitor vipoglanstat in systemic sclerosis-related Raynaud's. [PDF]

Rheumatology (Oxford)
Tornling G, Edenius C, Pauling JD, Denton CP, Olsson A, Kowalski J, Murray A, Anderson M, Bhat S, Del Galdo F, Hall F, Korkosz M, Krasowska D, Olas J, Smith V, van Laar JM, Vonk MC, Wojteczek A, Herrick AL.   +18 more
europepmc   +1 more source