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Prostaglandin E2synthase inhibition as a therapeutic target
Expert Opinion on Therapeutic Targets, 2009Most NSAIDs function by inhibiting biosynthesis of PGE(2) by inhibition of COX-1 and/or COX-2. Since COX-1 has a protective function in the gastro-intestinal tract (GIT), non-selective inhibition of both cycloxy genases leads to moderate to severe gastro-intestinal intolerance.
Jitesh P, Iyer +4 more
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Novel membrane-associated prostaglandin E synthase-2 from crustacean arthropods
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2014Prostaglandins (PG) have been shown to play important physiological roles in insects and marine invertebrates, yet the knowledge of their biosynthetic pathways is often lacking. Recently, we described cyclooxygenases in two amphipod crustaceans, Gammarus sp. and Caprella sp.
Kristella, Hansen +3 more
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Purification and characterization of recombinant microsomal prostaglandin E synthase-1
Protein Expression and Purification, 2002Recombinant human microsomal prostaglandin E(2) synthase-1 (mPGES-1) was expressed in a baculovirus-Sf9 cell system. The mPGES-1 was solubilized from Sf9 cell membranes with diheptanoylphosphatidylcholine and purified in the presence of octylglucoside using hydroxyapatite column chromatography.
Marc, Ouellet +6 more
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Immunolocalization of a microsomal prostaglandin E synthase in rabbit kidney
American Journal of Physiology-Renal Physiology, 2003PGE2, the major cyclooxygenase (COX) metabolite of arachidonic acid, is an important paracrine regulator of numerous tubular and vascular functions in the kidney. To date, COX activity has been considered the key step in prostaglandin synthesis and is well characterized.
Amanda L, Fuson +4 more
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