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Pathophysiological role of prostaglandin E synthases in liver diseases
Prostaglandins and Other Lipid Mediators, 2021Prostaglandin E synthases (PGESs) convert cyclooxygenase (COX)-derived prostaglandin H2 (PGH2) into prostaglandin E2 (PGE2) and comprise at least three types of structurally and biologically distinct enzymes. Two of these, namely microsomal prostaglandin E synthase-1 (mPGES-1) and mPGES-2, are membrane-bound enzymes.
Ying Sun
exaly +3 more sources
Expression of prostaglandin E synthases in the bovine oviduct
Theriogenology, 2010The oviduct is a specialized organ responsible for the storage and the transport of male and female gametes. It also provides an optimal environment for final gamete maturation, fertilization, and early embryo development. Prostaglandin (PG) E(2) is involved in many female reproductive functions, including ovulation, fertilization, implantation, and ...
M A Fortier
exaly +3 more sources
Cyclooxygenases and prostaglandin E synthases in preimplantation mouse embryos
Zygote, 2005 Prostaglandin E2 (PGE2) is shown to be essential for female reproduction. Cyclooxygenase (COX) is a rate-limiting enzyme in prostaglandin synthesis from arachidonic acid and exists in two isoforms: COX-1 and COX-2. Prostaglandin E synthase (PGES) is a terminal prostanoid synthase and can catalyse the isomerization of the COX product PGH2 to PGE2 ...
Tan, H. N. +3 more
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Sequential induction of prostaglandin E and D synthases in inflammation
Biochemical and Biophysical Research Communications, 2005Enhanced biosynthesis of prostaglandin (PG)D(2) and subsequent formation of 15-deoxy-Delta(12,14)-PGJ(2) has been suggested to contribute to resolution of inflammation. The primary aim of the present study in mouse heart was, therefore, to determine at the transcriptional level if there is sequential induction of PGE and PGD synthases (S) during ...
Rufina Schuligoi +2 more
exaly +3 more sources
Prostaglandins & Other Lipid Mediators, 2002
Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG)H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions.
Makoto, Murakami +3 more
openaire +2 more sources
Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG)H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions.
Makoto, Murakami +3 more
openaire +2 more sources
Prostaglandin E synthase in the pathophysiology of arthritis
Fundamental & Clinical Pharmacology, 2005AbstractProstaglandin E synthase (PGES) is a recently identified terminal enzyme that acts downstream of cyclooxygenase and catalyzes the conversion of prostaglandin (PG) H2 to PGE2. At least three isozymes have been cloned so far, which are called membrane‐associated PGES (mPGES)‐1, mPGES‐2, and cytosolic PGES.
Fumiaki, Kojima +2 more
openaire +2 more sources
Effects of flurbiprofen and flurbinitroxybutylester on prostaglandin endoperoxide synthases
European Journal of Pharmacology, 1996 The aim of our study was to evaluate the selectivity of flurbiprofen and flurbinitroxybutylester for inhibition of the cyclooxygenase activity of prostaglandin endoperoxide synthase-2 vs. prostaglandin endoperoxide synthase-1 in human blood monocytes and
Maria G Sciulli +2 more
exaly +2 more sources