Results 241 to 250 of about 9,035 (267)

Two Types of Microsomal Prostaglandin E Synthase: Glutathione-Dependent and -Independent Prostaglandin E Synthases

Biochemical and Biophysical Research Communications, 1997
Prostaglandin (PG) E synthase was found to be widely distributed in the microsomal fractions of rat organs. Among them, an extremely high activity was seen in the deferent duct (112 nmol/min x mg) and other genital accessory organs (10-20 nmol/min x mg). In non-genital organs, the kidney had the highest activity (8 nmol/min x mg).
K, Watanabe, K, Kurihara, Y, Tokunaga, O, Hayaishi   +3 more
openaire   +2 more sources

Expression of prostaglandin E synthase in Barrett’s cancer

Diseases of the Esophagus, 2008
Expression of prostaglandin E synthase (PGES) - an enzyme of the prostaglandin biosynthetic pathway with suspected impact on carcinogenesis--was studied in Barrett's cancer to determine its pathogenetic role and prognostic impact in this entity. Expression analysis of PGES was performed on mRNA level (quantitative reverse transcription polymerase chain
B H A, von Rahden, H J, Stein, S A, Hartl, J, Theisen, B, Stigler, J R, Siewert, M, Sarbia   +6 more
openaire   +2 more sources

Immunolocalization of a microsomal prostaglandin E synthase in rabbit kidney

American Journal of Physiology-Renal Physiology, 2003
PGE2, the major cyclooxygenase (COX) metabolite of arachidonic acid, is an important paracrine regulator of numerous tubular and vascular functions in the kidney. To date, COX activity has been considered the key step in prostaglandin synthesis and is well characterized.
Amanda L, Fuson, Peter, Komlosi, Tino M, Unlap, P Darwin, Bell, János, Peti-Peterdi   +4 more
openaire   +2 more sources

Characterization of Microsomal, Glutathione Dependent Prostaglandin E Synthase

2002
Terminal prostanoid synthases constitute a group of several specific enzymes that catalyze the further metabolism of cyclooxygenase-derived prostaglandin H2. The efficient biosynthesis of prostaglandin E2 requires prostaglandin E synthase (E.C. 5.3.99.3). High prostaglandin E synthase (PGES) activity is found in the sheep and bovine vesicular gland. In
Per-Johan, Jakobsson, Staffan, Thorén, Ralf, Morgenstern, Bengt, Samuelsson   +3 more
openaire   +2 more sources

Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity

Biochemical and Biophysical Research Communications, 2021
Microsomal prostaglandin (PG) E synthase-1 (mPGES-1) and prostacyclin (PGI2) synthase (PGIS) are PG terminal synthases that work downstream of cyclooxygenase and synthesize PGE2 and PGI2, respectively. Although the involvement of PG receptors in acquired cutaneous immune responses was recently shown, the roles of these PG terminal synthases remain ...
Tsubasa, Ochiai, Yuka, Sasaki, Hiroshi, Kuwata, Yoshihito, Nakatani, Chieko, Yokoyama, Shuntaro, Hara   +5 more
openaire   +2 more sources

Purification and characterization of recombinant microsomal prostaglandin E synthase-1

Protein Expression and Purification, 2002
Recombinant human microsomal prostaglandin E(2) synthase-1 (mPGES-1) was expressed in a baculovirus-Sf9 cell system. The mPGES-1 was solubilized from Sf9 cell membranes with diheptanoylphosphatidylcholine and purified in the presence of octylglucoside using hydroxyapatite column chromatography.
Marc, Ouellet, Jean-Pierre, Falgueyret, Po Hien, Ear, Ally, Pen, Joseph A, Mancini, Denis, Riendeau, M David, Percival   +6 more
openaire   +2 more sources

A Novel Type of Membrane-Associated Prostaglandin E Synthase

2003
Prostaglandin (PG) E2 is widely distributed in various organs, and exhibits various biologically important activities such as smooth muscle dilatation/contraction, body temperature regulation, induction of pain, stimulation of bone resorption, and inhibition of immune responses. PGE synthase catalyzes the conversion of PGH2 to PGE2. About 25 years ago,
Kikuko, Watanabe, Yoshihiro, Ohmiya, Hiroaki, Ohkubo, Naomi, Tanikawa, Masami, Kojima, Seiji, Ito   +5 more
openaire   +2 more sources

Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target

Pharmacological Reviews, 2007
Prostaglandin E(2) (PGE(2)) is the most abundant prostaglandin in the human body. It has a large number of biological actions that it exerts via four types of receptors, EP1-4. PGE(2) is formed from arachidonic acid by cyclooxygenase (COX-1 and COX-2)-catalyzed formation of prostaglandin H(2) (PGH(2)) and further transformation by PGE synthases.
Bengt, Samuelsson, Ralf, Morgenstern, Per-Johan, Jakobsson   +2 more
openaire   +2 more sources

Prostaglandin E Synthase: A Novel Drug Target for Inflammation and Cancer

Current Pharmaceutical Design, 2006
Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG) H(2) to PGE(2), occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions.
Makoto, Murakami, Ichiro, Kudo
openaire   +2 more sources

Prostaglandin E₂synthase inhibition as a therapeutic target

Expert Opinion on Therapeutic Targets, 2009
Most NSAIDs function by inhibiting biosynthesis of PGE(2) by inhibition of COX-1 and/or COX-2. Since COX-1 has a protective function in the gastro-intestinal tract (GIT), non-selective inhibition of both cycloxy genases leads to moderate to severe gastro-intestinal intolerance.
Jitesh P, Iyer, Punit K, Srivastava, Rishabh, Dev, Sunanda G, Dastidar, Abhijit, Ray   +4 more
openaire   +2 more sources