Results 281 to 290 of about 78,509 (319)
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Biochemical and Biophysical Research Communications, 1997
Prostaglandin (PG) E synthase was found to be widely distributed in the microsomal fractions of rat organs. Among them, an extremely high activity was seen in the deferent duct (112 nmol/min x mg) and other genital accessory organs (10-20 nmol/min x mg).
Kikuko Watanabe +3 more
semanticscholar +4 more sources
Prostaglandin (PG) E synthase was found to be widely distributed in the microsomal fractions of rat organs. Among them, an extremely high activity was seen in the deferent duct (112 nmol/min x mg) and other genital accessory organs (10-20 nmol/min x mg).
Kikuko Watanabe +3 more
semanticscholar +4 more sources
Prostaglandin E Synthases in Zebrafish [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2004 Objective— Prostaglandin E synthases (PGESs) are being explored as antiinflammtory drug targets as alternatives to cyclooxygenase (COX)-2. Located downstream of the cyclooxygenases, PGESs catalyze PGE 2 formation, and deletion of microsomal (m)-PGES-1 abrogates inflammation ...
B. Pini +5 more
semanticscholar +3 more sources
Expression of prostaglandin E synthases in the bovine oviduct.
Theriogenology, 2010The oviduct is a specialized organ responsible for the storage and the transport of male and female gametes. It also provides an optimal environment for final gamete maturation, fertilization, and early embryo development. Prostaglandin (PG) E(2) is involved in many female reproductive functions, including ovulation, fertilization, implantation, and ...
D. Gauvreau +4 more
semanticscholar +4 more sources
Cyclooxygenases and prostaglandin E synthases in preimplantation mouse embryos
Zygote, 2005Prostaglandin E2 (PGE2) is shown to be essential for female reproduction. Cyclooxygenase (COX) is a rate-limiting enzyme in prostaglandin synthesis from arachidonic acid and exists in two isoforms: COX-1 and COX-2. Prostaglandin E synthase (PGES) is a terminal prostanoid synthase and can catalyse the isomerization of the COX product PGH2 to PGE2 ...
H. Tan, Y. Liu, H. Diao, Zeng-Ming Yang
semanticscholar +4 more sources
Sequential induction of prostaglandin E and D synthases in inflammation.
Biochemical and Biophysical Research Communications, 2005Enhanced biosynthesis of prostaglandin (PG)D(2) and subsequent formation of 15-deoxy-Delta(12,14)-PGJ(2) has been suggested to contribute to resolution of inflammation. The primary aim of the present study in mouse heart was, therefore, to determine at the transcriptional level if there is sequential induction of PGE and PGD synthases (S) during ...
R. Schuligoi +4 more
semanticscholar +3 more sources
Pathophysiological role of prostaglandin E synthases in liver diseases
Prostaglandins & Other Lipid Mediators, 2021Prostaglandin E synthases (PGESs) convert cyclooxygenase (COX)-derived prostaglandin H2 (PGH2) into prostaglandin E2 (PGE2) and comprise at least three types of structurally and biologically distinct enzymes. Two of these, namely microsomal prostaglandin E synthase-1 (mPGES-1) and mPGES-2, are membrane-bound enzymes.
Gao Hang +4 more
openaire +3 more sources