Results 291 to 300 of about 78,509 (319)
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Prostaglandins & Other Lipid Mediators, 2002
Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG)H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions.
Yoshihito Nakatani +3 more
openaire +2 more sources
Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG)H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions.
Yoshihito Nakatani +3 more
openaire +2 more sources
Prostaglandin E synthase in the pathophysiology of arthritis
Fundamental & Clinical Pharmacology, 2005AbstractProstaglandin E synthase (PGES) is a recently identified terminal enzyme that acts downstream of cyclooxygenase and catalyzes the conversion of prostaglandin (PG) H2 to PGE2. At least three isozymes have been cloned so far, which are called membrane‐associated PGES (mPGES)‐1, mPGES‐2, and cytosolic PGES.
Shinichi Kawai +3 more
openaire +3 more sources
Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target
Pharmacological Reviews, 2007Prostaglandin E(2) (PGE(2)) is the most abundant prostaglandin in the human body. It has a large number of biological actions that it exerts via four types of receptors, EP1-4. PGE(2) is formed from arachidonic acid by cyclooxygenase (COX-1 and COX-2)-catalyzed formation of prostaglandin H(2) (PGH(2)) and further transformation by PGE synthases.
B. Samuelsson +2 more
semanticscholar +4 more sources
American Journal of Physiology. Heart and Circulatory Physiology, 2005
The proinflammatory mediator cyclooxygenase (COX)-2 and its product PGE(2) are induced in the ischemic heart, contributing to inflammatory cell infiltration, fibroblast proliferation, and cardiac hypertrophy.
G. Giannico, Mariela Mendez, M. Lapointe
semanticscholar +1 more source
The proinflammatory mediator cyclooxygenase (COX)-2 and its product PGE(2) are induced in the ischemic heart, contributing to inflammatory cell infiltration, fibroblast proliferation, and cardiac hypertrophy.
G. Giannico, Mariela Mendez, M. Lapointe
semanticscholar +1 more source
Expression of prostaglandin E synthase in Barrett’s cancer
Diseases of the Esophagus, 2008Expression of prostaglandin E synthase (PGES) - an enzyme of the prostaglandin biosynthetic pathway with suspected impact on carcinogenesis--was studied in Barrett's cancer to determine its pathogenetic role and prognostic impact in this entity. Expression analysis of PGES was performed on mRNA level (quantitative reverse transcription polymerase chain
H. J. Stein +6 more
openaire +3 more sources
Animal science journal = Nihon chikusan Gakkaiho, 2018
The spleen is a unique lymphoid organ that plays a key role in immune regulation. Interferon-tau induces upregulation of interferon-stimulated gene 15-kDa protein (ISG15) in the uterus during early pregnancy in sheep.
Ling Yang +6 more
semanticscholar +1 more source
The spleen is a unique lymphoid organ that plays a key role in immune regulation. Interferon-tau induces upregulation of interferon-stimulated gene 15-kDa protein (ISG15) in the uterus during early pregnancy in sheep.
Ling Yang +6 more
semanticscholar +1 more source
Immunolocalization of a microsomal prostaglandin E synthase in rabbit kidney
American Journal of Physiology-Renal Physiology, 2003PGE2, the major cyclooxygenase (COX) metabolite of arachidonic acid, is an important paracrine regulator of numerous tubular and vascular functions in the kidney. To date, COX activity has been considered the key step in prostaglandin synthesis and is well characterized.
Amanda L. Fuson +4 more
openaire +3 more sources
Biochemical and Biophysical Research Communications, 2021
Microsomal prostaglandin (PG) E synthase-1 (mPGES-1) and prostacyclin (PGI2) synthase (PGIS) are PG terminal synthases that work downstream of cyclooxygenase and synthesize PGE2 and PGI2, respectively. Although the involvement of PG receptors in acquired cutaneous immune responses was recently shown, the roles of these PG terminal synthases remain ...
Hiroshi Kuwata +5 more
openaire +2 more sources
Microsomal prostaglandin (PG) E synthase-1 (mPGES-1) and prostacyclin (PGI2) synthase (PGIS) are PG terminal synthases that work downstream of cyclooxygenase and synthesize PGE2 and PGI2, respectively. Although the involvement of PG receptors in acquired cutaneous immune responses was recently shown, the roles of these PG terminal synthases remain ...
Hiroshi Kuwata +5 more
openaire +2 more sources
Investigation of the Substrate‐Binding Site of a Prostaglandin E Synthase in Bombyx mori
The Protein Journal, 2021Prostaglandin E synthase (PGES) catalyzes the conversion of prostaglandin H2 to prostaglandin E2 in the presence of glutathione (GSH) in mammals. Amid the limited knowledge on prostaglandin and its related enzymes in insects, we recently identified PGES from the silkworm Bombyx mori (bmPGES) and determined its crystal structure complexed with GSH.
Kohji Yamamoto, Aiko Hirowatari
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Prostaglandin E2synthase inhibition as a therapeutic target
Expert Opinion on Therapeutic Targets, 2009Most NSAIDs function by inhibiting biosynthesis of PGE(2) by inhibition of COX-1 and/or COX-2. Since COX-1 has a protective function in the gastro-intestinal tract (GIT), non-selective inhibition of both cycloxy genases leads to moderate to severe gastro-intestinal intolerance.
Sunanda G. Dastidar +4 more
openaire +3 more sources