Results 301 to 310 of about 78,509 (319)

Prostaglandin E Synthase: A Novel Drug Target for Inflammation and Cancer

Current Pharmaceutical Design, 2006
Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG) H(2) to PGE(2), occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions.
Makoto Murakami, Ichiro Kudo
openaire   +2 more sources

A Novel Type of Membrane-Associated Prostaglandin E Synthase

2003
Prostaglandin (PG) E2 is widely distributed in various organs, and exhibits various biologically important activities such as smooth muscle dilatation/contraction, body temperature regulation, induction of pain, stimulation of bone resorption, and inhibition of immune responses. PGE synthase catalyzes the conversion of PGH2 to PGE2. About 25 years ago,
Hiroaki Ohkubo, Naomi Tanikawa, Kikuko Watanabe, Masami Kojima, Seiji Ito, Yoshihiro Ohmiya   +5 more
openaire   +3 more sources

Purification and characterization of recombinant microsomal prostaglandin E synthase-1

Protein Expression and Purification, 2002
Recombinant human microsomal prostaglandin E(2) synthase-1 (mPGES-1) was expressed in a baculovirus-Sf9 cell system. The mPGES-1 was solubilized from Sf9 cell membranes with diheptanoylphosphatidylcholine and purified in the presence of octylglucoside using hydroxyapatite column chromatography.
Po Hien Ear, Joseph A. Mancini, Marc Ouellet, Denis Riendeau, Ally Pen, Jean-Pierre Falgueyret, M. David Percival   +6 more
openaire   +3 more sources

Characterization of Microsomal, Glutathione Dependent Prostaglandin E Synthase

2002
Terminal prostanoid synthases constitute a group of several specific enzymes that catalyze the further metabolism of cyclooxygenase-derived prostaglandin H2. The efficient biosynthesis of prostaglandin E2 requires prostaglandin E synthase (E.C. 5.3.99.3). High prostaglandin E synthase (PGES) activity is found in the sheep and bovine vesicular gland. In
Ralf Morgenstern, Bengt Samuelsson, Per-Johan Jakobsson, Staffan Thorén   +3 more
openaire   +3 more sources

Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2010
The importance of prostaglandin E(2) in various pathophysiological events emphasizes the necessity of understanding the role of PGE synthases (PGESs) in vivo. However, there has been no report on the functional relevance of microsomal PGES-1 (mPGES-1) to
T. Ae, T. Ohno, Youichiro Hattori, Tatsunori Suzuki, K. Hosono, Tsutomu Minamino, Takehito Sato, S. Uematsu, S. Akira, W. Koizumi, M. Majima   +10 more
semanticscholar   +1 more source

Distribution of microsomal prostaglandin E synthase‐1 in the mouse brain

Journal of Comparative Neurology, 2014
ABSTRACTPrevious studies in rats have demonstrated that microsomal prostaglandin E synthase‐1 (mPGES‐1) is induced in brain vascular cells that also express inducible cyclooxygenase‐2, suggesting that such cells are the source of the increased PGE2 levels that are seen in the brain following peripheral immune stimulation, and that are associated with ...
Anna Eskilsson, Anders Blomqvist, Masanori Tachikawa, Masanori Tachikawa, Ken Ichi Hosoya   +4 more
openaire   +3 more sources

Purification and characterization of membrane-bound prostaglandin E synthase from bovine heart

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1999
Prostaglandin (PG) E synthase was solubilized with 6 mM sodium deoxycholate from the microsomal fraction of bovine hearts. The enzyme was purified by about 800-fold to apparent homogeneity. The specific activity of the purified enzyme was about 830 mU/mg of protein, and the K(m) value for PGH(2) was 24 microM.
Toshiko Suzuki, Kayoko Kurihara, Kikuko Watanabe   +2 more
openaire   +6 more sources

Expression of microsomal prostaglandin E synthase‐1 in human hepatocelluar carcinoma

Liver International, 2007
AbstractBackground/Aims: The objective of this study was to evaluate the expression of microsomal prostaglandin E synthase‐1 (mPGES‐1) in hepatocellular carcinoma (HCC) tissues.Methods: Forty surgically resected HCC tissues with adjacent non‐tumorous liver tissues and 14 surgically resected, histologically normal liver tissues were used.
Yumi Meda, Seigo Abiru, Ken Taniguchi, Kiyoshi Migita, Manabu Daikoku, Yasushi Takii, Masahiro Ito, Kazuyuki Ohata, Minoru Nakamura, Hiromi Ishibashi, Hiroshi Yatsuhashi, Hikaru Fujioka, Atsumasa Komori, Shinji Shimoda, Koji Yano   +14 more
openaire   +3 more sources

Clinical significance of prostaglandin E synthase expression in gastric cancer tissue

Human Pathology, 2007
Studies have linked microsomal prostaglandin E synthase (mPGES)-1 with gastric cancer. The purpose of this study was to determine mPGES-1, mPGES-2, and cytosolic PGES (cPGES) expression in gastric cancer and to evaluate the correlation between mPGES-1 and mPGES-2 expression and clinicopathological factors and cyclooxygenase-2 expression.
Atsushi Tatsuguchi, Ken Wada, Seiji Futagami, Tetsuro Hiratsuka, Teruo Kiyama, Katya Gudis, Takashi Tajiri, Yuh Fukuda, Choitsu Sakamoto, Kazumasa Miyake   +9 more
openaire   +3 more sources

Identification and Characterization of a Novel Type of Membrane-Associated Prostaglandin E Synthase

Biochemical and Biophysical Research Communications, 2002
Membrane-associated prostaglandin E synthase (mPGE synthase) was previously purified to apparent homogeneity from the microsomal fraction of bovine heart (Watanabe, K., et al., Biochim. Biophys. Acta 1439, 406--414, 1999). The N-terminal 22-amino acid sequence of the purified enzyme was identical to that of the 88th to 109th amino acids deduced from ...
Hiroaki Ohkubo, Seiji Ito, Yoshihiro Ohmiya, Masami Kojima, Naomi Tanikawa, Kikuko Watanabe, Katsuyuki Hashimoto, Kenji Kangawa   +7 more
openaire   +3 more sources