Results 91 to 100 of about 345,095 (348)
Arthritis &Rheumatology, EarlyView.Objective Chondrocytemetabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein posttranslational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK), and its regulator sirtuin 5 (Sirt5) in OA ...
Huanhuan Liu +11 more
wiley +1 more source
Gout and NLRP3 inflammasome biology
Arthritis &Rheumatology, Accepted Article.This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilisation, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal‐induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley +1 more source
Revista Colombiana de Obstetricia y Ginecología, 2009 Objetivos: revisar la asociación que existe entre los diferentes mecanismos inmunes y los eventos endocrinos necesarios para la regulación de la reproducción humana.
Ivonne Díaz-Yamal, Carolina Ruiz-Wagner
doaj
Prostaglandin E2 and pain--an update.
Biological and Pharmaceutical Bulletin, 2011 Prostaglandin E(2) (PGE(2)), a cyclooxygenase (COX) product, is the best known lipid mediator that contributes to inflammatory pain. Nonsteroidal anti-inflammatory drugs (NSAIDs), inhibitors of COX-1 and/or COX-2, suppress inflammatory pain by reducing ...
A. Kawabata
semanticscholar +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Abnormalities in pain regulatory mechanisms are common in patients with rheumatoid arthritis (RA). We investigated whether pain sensitization changes after treatment with a disease modifying anti‐rheumatic drug (DMARD) and explored associations between changes in pain sensitization and disease activity.
Burcu Aydemir +10 more
wiley +1 more source
Pharmacology and relevant drug interactions of metamizole
British Journal of Clinical Pharmacology, EarlyView.Metamizole is a frequently prescribed analgesic because of its favourable benefit/risk ratio compared with classic NSAIDs. However, increasing research shows that metamizole displays several drug interactions that are relevant to clinical practice. We reviewed the literature to summarize the pharmacology and most clinically relevant drug interactions ...
David J. Brinkman +3 more
wiley +1 more source
Preliminary investigation on antipyretic activity of Cuscuta Reflexa in rats
Journal of Advanced Pharmaceutical Technology & Research, 2010 In present study, the antipyretic activity of aqueous and ethanol extracts from Cuscuta reflexa Roxb. (Cuscutaceae) was evaluated using Brewer′s yeast induced pyrexia in rats.
Sanjib Bhattacharya, Bodhisattva Roy
doaj
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, EarlyView.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source
Host Lipid Mediators in Leprosy: The Hypothesized Contributions to Pathogenesis
Frontiers in Immunology, 2018 The spectrum of clinical forms observed in leprosy and its pathogenesis are dictated by the host’s immune response against Mycobacterium leprae, the etiological agent of leprosy.
Carlos A. M. Silva, John T. Belisle
doaj +1 more source
THE OCCURRENCE OF PROSTAGLANDIN E2 IN SPLENIC VENOUS BLOOD OF THE DOG FOLLOWING SPLENIC NERVE STIMULATION [PDF]
, 1968 B. N. Davies +2 more
openalex +1 more source