Results 101 to 110 of about 248,083 (296)

"THE ROLE OF PROSTAGLANDINS AND MAST CELLS IN THE MODULATION OF ACUTE ACID-INDUCED TRACHEAL CONTRACTION IN RAT" [PDF]

Acta Medica Iranica, 2004
The exact role of the epithelial lining of the trachea in modulating the bronchial tone is controversial. The present study was an attempt to verify the role of both prostaglandins and mast cells in the acute phase of acid inspiration in rat. Four groups
M. H. Pipelzadeh, A. A. Hemmati, A. Dezfulian, M. H. Koochek A. Rostami   +3 more
doaj  

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Papel de la inmunología en la endocrinología ginecológica: revisión de la literatura The role of immunology in gynaecological endocrinology: a literature review

Revista Colombiana de Obstetricia y Ginecología, 2009
Objetivos: revisar la asociación que existe entre los diferentes mecanismos inmunes y los eventos endocrinos necesarios para la regulación de la reproducción humana.
Ivonne Díaz-Yamal, Carolina Ruiz-Wagner
doaj  

Divergent gene expression of PTGS1 and PTGS2 along the disease course of chronic myeloid leukaemia

Frontiers in Oncology
IntroductionChronic myeloid leukaemia (CML) is a chronic myeloproliferative disorder caused by the reciprocal translocation of chromosomes 9 and 22. This genetic abnormality leads to the uncontrolled proliferation of myeloid lineage cells, ultimately ...
Denise K. Wosniaki, Bianca N. Kusma, Anelis M. Marin, Eduardo C. Munhoz, João S. de H. Farias, Eduarda B. Mendes, Mateus N. Aoki, Dalila L. Zanette   +7 more
doaj   +1 more source

Efficacy and Patient Tolerability of Omidenepag Isopropyl in the Treatment of Glaucoma and Ocular Hypertension

Clinical Ophthalmology, 2022
Masato Matsuo,1 Yotaro Matsuoka,2 Masaki Tanito1 1Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo City, Shimane, 693-8501, Japan; 2Division of Ophthalmology, Matsue Red Cross Hospital, Matsue, Shimane, 690-8506 ...
Matsuo M, Matsuoka Y, Tanito M
doaj  

CYP4F3B is induced by PGA1 in human liver cells: a regulation of the 20-HETE synthesis

Journal of Lipid Research, 2008
The regulation of the human liver-specific cytochrome P450 4F3B (CYP4F3B) isoform, a splice variant of the CYP4F3 gene with strong substrate specificity for long chain fatty acids, is yet an unsolved question. This report provides the first evidence that
Joseph Antoun, Sophie Goulitquer, Yolande Amet, Yvonne Dreano, Jean-Pierre Salaun, Laurent Corcos, Emmanuelle Plée-Gautier   +6 more
doaj   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Adipose‐derived mesenchymal stem cell injection into the KI10 acupoint mitigates cartilage damage in KOA rats through PGE2‐mediated α7nAChR/NF‐κB pathway

Animal Models and Experimental Medicine, EarlyView.
In our research, KOA rat models were established and treated with ADSC injection into the KI10 acupoint. Pain relief, behavioral function, and joint structural improvements were systematically assessed using ethological tests, imaging, histopathological staining, transmission electron microscopy, and molecular analyses.
Mengwei Dong, Wenfang Li, Wanpeng Yang, Te Ba, Nan Nan, Yang Liu, Jing Han, Huiqin Hao   +7 more
wiley   +1 more source

Prostaglandin-Associated Periorbitopathy: Report of three Cases and Review of Fundamental Physiopathology

, 2013
Prostaglandin analogues, latanoprost and travoprost, and one of the prostamides, bimatoprost, are widely used in glaucoma practice with their efficacious intraocular pressure-lowering effect.
Murat Küçükevcilioğlu, Atilla Bayer
core   +1 more source