Results 11 to 20 of about 501,484 (388)

Antinociceptive activity of the S1P-receptor agonist FTY720 [PDF]

, 2008
FTY720 is a novel immunosuppressive drug that inhibits the egress of lymphocytes from secondary lymphoid tissues and thymus. In its phosphorylated form FTY720 is a potent S1P receptor agonist.
Angioni, Carlo Federico, Brenneis, Christian, Coste, Ovidiu, Geisslinger, Gerd, Marian, Claudiu, Pierre, Sandra, Popp, Laura, Schmidt, Helmut, Scholich, Klaus   +8 more
core   +1 more source

Attenuation of ischemic liver injury by prostaglandin E1 analogue, misoprostol, and prostaglandin I2 analogue, OP-41483 [PDF]

, 1998
Background: Prostaglandin has been reported to have protective effects against liver injury. Use of this agent in clinical settings, however, is limited because of drugrelated side effects.
Ishizaki, N, Jin, MB, Kawashima, Y, Shimamura, T, Starzl, TE, Todo, S, Totsuka, E, Urakami, A, Zhu, Y   +8 more
core   +1 more source

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

Proceedings of the National Academy of Sciences of the United States of America, 1975
An unstable [t1/2 at 37 degrees = 32 +/- 2 (SD) sec] intermediate, thromboxane A2, was detected in the conversion of prostaglandin G2 into 8-(1-hydroxy-3-oxopropyl)-9,12L-dihydroxy-5,10-heptadecadienoic acid (thromboxane B2) in platelets.
M. Hamberg, J. Svensson, B. Samuelsson
semanticscholar   +1 more source

Effects of antenatal betamethasone on preterm human and mouse ductus arteriosus: comparison with baboon data. [PDF]

, 2018
BackgroundAlthough studies involving preterm infants ≤34 weeks gestation report a decreased incidence of patent ductus arteriosus after antenatal betamethasone, studies involving younger gestation infants report conflicting results.MethodsWe used preterm
A El-Khuffash, AC Vidaeff, AM Ring, B Schmidt, B Thebaud, C Kahler, Christopher W. Hooper, Donald McCurnin, E Michelakis, E Pagni, EJ Plosa, EL Shelton, Elaine L. Shelton, Erin J. Plosa, F Coceani, F Schena, F Waffarn, Ginger L. Milne, H Liu, H Ozdemir, HW Park, J Reese, JD Stewart, Jeff Reese, JJ Coalson, John T. Benjamin, K Momma, K Toyoshima, LW Doyle, LW Gonzales, M Eronen, M Liebowitz, M Liebowitz, N Waleh, N Waleh, N Waleh, N Wasserstrum, Nahid Waleh, Naoko Brown, Noah J. Ehinger, OM Peltoniemi, PA Crowley, RD Roghair, RI Clyman, RI Clyman, Ronald I. Clyman, S Costa, Stanley Poole, Steven Seidner, W Onland, Y Ichikawa   +50 more
core   +2 more sources

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2*

Journal of Biological Chemistry, 1996
Prostaglandin endoperoxide H synthases (PGHSs) catalyze the conversion of arachidonic acid and O2 to PGH2, the committed step in prostanoid biosynthesis (Fig. 1) (1).
W. Smith, R. Garavito, D. Dewitt
semanticscholar   +1 more source

The pharmacological management of erectile dysfunction

South African Family Practice, 2015
The inability to attain or maintain a penile erection sufficient for sexual intercourse is a common problem experienced by a third of men over the age of 40 years.
Andre Marais
doaj   +1 more source

Multi‐omics analyses reveal the interaction between colonic microbiota and host in Min and Yorkshire pigs

Animal Research and One Health, EarlyView., 2023
In the present study, we created the weight gain models with Min and Yorkshire pigs and conducted the metagenomics and metabolomics of colon contents and transcriptomics of colon tissue. Further, we revealed the characteristics and functions of the colonic microbiota in Min and Yorkshire pigs and analyzed their interactions with the host. Overall, this
Xiaoyu Huang, Huihui Li, Feng Cheng, Ligang Wang, Guoqing Cao, Lixian Wang, Lijun Shi   +6 more
wiley   +1 more source

Dual Behavior of Long-Chain Fatty Acids and Their Cyclooxygenase/Lipoxygenase Metabolites on Human Intestinal Caco-2 Cell Growth

Frontiers in Pharmacology, 2020
Etiology of colorectal cancer (CRC) is related, at least in part, with nutritional profile and epidemiological data indicating a key role of dietary fat on CRC pathogenesis. Moreover, inflammation and eicosanoids produced from arachidonic acid might have
Carolina E. Storniolo, Carolina E. Storniolo, Marisol Cabral, Marisol Cabral, Maria A. Busquets, Maria A. Busquets, Raquel Martín-Venegas, Raquel Martín-Venegas, Juan J. Moreno, Juan J. Moreno, Juan J. Moreno   +10 more
doaj   +1 more source

Aspirin Inhibition of Prostaglandin Synthesis Impairs Mosquito Egg Development

Cells, 2022
Several endocrine signals mediate mosquito egg development, including 20-hydroxyecdysone (20E). This study reports on prostaglandin E2 (PGE2) as an additional, but core, mediator of oogenesis in a human disease-vectoring mosquito, Aedes albopictus ...
Duyeol Choi, Md. Abdullah Al Baki, Shabbir Ahmed, Yonggyun Kim   +3 more
doaj   +1 more source

Modeling of biological doses and mechanical effects on bone transduction [PDF]

Journal of Theoretical Biology 274, 1 (2011) 36-42, 2011
Shear stress, hormones like parathyroid and mineral elements like calcium mediate the amplitude of stimulus signal which affects the rate of bone remodeling. The current study investigates the theoretical effects of different metabolic doses in stimulus signal level on bone.
arxiv   +1 more source