Results 51 to 60 of about 348,697 (337)

"THE ROLE OF PROSTAGLANDINS AND MAST CELLS IN THE MODULATION OF ACUTE ACID-INDUCED TRACHEAL CONTRACTION IN RAT" [PDF]

Acta Medica Iranica, 2004
The exact role of the epithelial lining of the trachea in modulating the bronchial tone is controversial. The present study was an attempt to verify the role of both prostaglandins and mast cells in the acute phase of acid inspiration in rat. Four groups
M. H. Pipelzadeh, A. A. Hemmati, A. Dezfulian, M. H. Koochek A. Rostami   +3 more
doaj  

Prostaglandin pathway gene expression in human placenta, amnion and choriodecidua is differentially affected by preterm and term labour and by uterine inflammation

BMC Pregnancy and Childbirth, 2014
BackgroundElucidation of the biochemical pathways involved in activation of preterm and term human labour would facilitate the development of effective management and inform judgements regarding the necessity for preterm tocolysis and post-term induction.
Robert J. Phillips, M. Fortier, A. López Bernal   +2 more
semanticscholar   +1 more source

Prostaglandins and prostaglandin receptor antagonism in migraine [PDF]

The Journal of Headache and Pain, 2013
Human models of headache may contribute to understanding of prostaglandins' role in migraine pathogenesis. The current thesis investigated the migraine triggering effect of prostaglandin E2 (PGE2) in migraine patients without aura, the efficacy of a novel EP4 receptor antagonist, BGC20-1531, in prevention of PGE2-induced headache and the ability of ...
openaire   +3 more sources

Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs

Advanced Healthcare Materials, EarlyView.
This study demonstrates the safety of repeated application of three types of microarray patches (MAPs), hydrogelforming, dissolving, and implantable, over four weeks in miniature pigs. No adverse skin or systemic effects were observed, supporting the clinical potential of MAPs as safe and effective drug delivery platforms.
Qonita Kurnia Anjani, Aaron R. J. Hutton, Peter E. McKenna, Eneko Larrañeta, Ryan F. Donnelly   +4 more
wiley   +1 more source

LC/MS/MS method for analysis of E2 series prostaglandins and isoprostanes

Journal of Lipid Research, 2011
15-series prostaglandins (PGE2s) and isoprostanes (isoPGE2s) are robust biomarkers of oxidative stress, possess potent biological activity, and may be derived through cyclooxygenase or free radical pathways.
Stephen A. Brose, Brock T. Thuen, Mikhail Y. Golovko   +2 more
doaj  

15-Deoxy-Δ12,14-prostaglandin J2 inhibits multiple steps in the NF-κB signaling pathway

, 2000
Prostaglandin J2 (PGJ2) and its metabolites Δ12-PGJ2 and 15-deoxy-Δ12,14-PGJ2 (15d-PGJ2) are naturally occurring derivatives of prostaglandin D2 that have been suggested to exert antiinflammatory effects in vivo.
Daniel S. Straus, Gabriel Pascual, Mei Li, J. Welch, M. Ricote, C. Hsiang, L. L. Sengchanthalangsy, G. Ghosh, C. K. Glass   +8 more
semanticscholar   +1 more source

Machine‐Learning‐Aided Advanced Electrochemical Biosensors

Advanced Materials, EarlyView.
Electrochemical biosensors are highly sensitive, portable, and versatile. Advanced nanomaterials enhance their performance, while machine learning (ML) improves data analysis, minimizes interference, and optimizes sensor design. Despite progress in both fields, their combined potential in diagnostics remains underexplored.
Andrei Bocan, Roozbeh Siavash Moakhar, Carolina del Real Mata, Max Petkun, Tristan De Iure‐Grimmel, Sripadh Guptha Yedire, Hamed Shieh, Arash Khorrami Jahromi, Sahar Sadat Mahshid, Sara Mahshid   +9 more
wiley   +1 more source

Niacin, an old drug with a new twist

Journal of Lipid Research, 2013
Niacin (nicotinic acid) has been used for decades as a lipid-lowering drug. The clinical use of niacin to treat dyslipidemic conditions is limited by its side effects.
Wen-Liang Song, Garret A. FitzGerald
doaj  

Efficacy of Amnitear vs. Conventional Method for Artificial Rupture of Membranes: A Prospective Study [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Amnitear is a newer device which is to be worn over gloved index finger for doing artificial rupture of membranes. Aim: To evaluate the efficacy of Amnitear in doing Artificial Rupture of Membrane (ARM) and to compare the efficacy and ...
Nidhi Gupta, Aruna Nigam, Neha Varun, Snehlata Meena, Rashmi Aggarwalla   +4 more
doaj   +1 more source

Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells.

Cancer Research, 2007
A causative relationship between chronic inflammation and cancer has been postulated for many years, and clinical observations and laboratory experiments support the hypothesis that inflammation contributes to tumor onset and progression.
P. Sinha, V. Clements, A. Fulton, S. Ostrand-Rosenberg   +3 more
semanticscholar   +1 more source