Results 51 to 60 of about 345,095 (348)

Prostaglandin pathway gene expression in human placenta, amnion and choriodecidua is differentially affected by preterm and term labour and by uterine inflammation

BMC Pregnancy and Childbirth, 2014
BackgroundElucidation of the biochemical pathways involved in activation of preterm and term human labour would facilitate the development of effective management and inform judgements regarding the necessity for preterm tocolysis and post-term induction.
Robert J. Phillips, M. Fortier, A. López Bernal   +2 more
semanticscholar   +1 more source

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

"THE ROLE OF PROSTAGLANDINS AND MAST CELLS IN THE MODULATION OF ACUTE ACID-INDUCED TRACHEAL CONTRACTION IN RAT" [PDF]

Acta Medica Iranica, 2004
The exact role of the epithelial lining of the trachea in modulating the bronchial tone is controversial. The present study was an attempt to verify the role of both prostaglandins and mast cells in the acute phase of acid inspiration in rat. Four groups
M. H. Pipelzadeh, A. A. Hemmati, A. Dezfulian, M. H. Koochek A. Rostami   +3 more
doaj  

Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production [PDF]

Journal of Neuroimmunology 174(1-2): 39-51 (2006), 2007
In the present study, we show that ascorbic acid dose-dependently inhibited interleukin-1beta (IL-1beta)-mediated PGE2 synthesis in the human neuronal cell line, SK-N-SH. Furthermore, in combination with aspirin, ascorbic acid augmented the inhibitory effect of aspirin on PGE2 synthesis. However, ascorbic acid had no synergistic effect along with other
arxiv  

Prostaglandins and prostaglandin receptor antagonism in migraine [PDF]

The Journal of Headache and Pain, 2013
Human models of headache may contribute to understanding of prostaglandins' role in migraine pathogenesis. The current thesis investigated the migraine triggering effect of prostaglandin E2 (PGE2) in migraine patients without aura, the efficacy of a novel EP4 receptor antagonist, BGC20-1531, in prevention of PGE2-induced headache and the ability of ...
openaire   +3 more sources

15-Deoxy-Δ12,14-prostaglandin J2 inhibits multiple steps in the NF-κB signaling pathway

, 2000
Prostaglandin J2 (PGJ2) and its metabolites Δ12-PGJ2 and 15-deoxy-Δ12,14-PGJ2 (15d-PGJ2) are naturally occurring derivatives of prostaglandin D2 that have been suggested to exert antiinflammatory effects in vivo.
Daniel S. Straus, Gabriel Pascual, Mei Li, J. Welch, M. Ricote, C. Hsiang, L. L. Sengchanthalangsy, G. Ghosh, C. K. Glass   +8 more
semanticscholar   +1 more source

Accelerated Bone Healing via Electrical Stimulation

Advanced Science, EarlyView.
Electrical stimulation significantly impacts bone healing by enhancing osteoblast proliferation, differentiation, and vascularization through calmodulin/calcineurin/NFAT signaling. It also boosts macrophage function and cell migration, presenting a comprehensive approach to accelerating bone repair.
Jianfeng Sun, Wenqing Xie, Yuxiang Wu, Zhou Li, Yusheng Li   +4 more
wiley   +1 more source

LC/MS/MS method for analysis of E2 series prostaglandins and isoprostanes

Journal of Lipid Research, 2011
15-series prostaglandins (PGE2s) and isoprostanes (isoPGE2s) are robust biomarkers of oxidative stress, possess potent biological activity, and may be derived through cyclooxygenase or free radical pathways.
Stephen A. Brose, Brock T. Thuen, Mikhail Y. Golovko   +2 more
doaj  

Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells.

Cancer Research, 2007
A causative relationship between chronic inflammation and cancer has been postulated for many years, and clinical observations and laboratory experiments support the hypothesis that inflammation contributes to tumor onset and progression.
P. Sinha, V. Clements, A. Fulton, S. Ostrand-Rosenberg   +3 more
semanticscholar   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source