Results 71 to 80 of about 348,697 (337)

IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.

Proceedings of the National Academy of Sciences of the United States of America, 1988
The effect of human recombinant interleukin 4 (IL-4) on antibody production by normal peripheral blood mononuclear cells enriched for B cells was investigated. IL-4 preferentially induced IgE synthesis in vitro.
J. Pène, F. Rousset, F. Brière, I. Chrétien, J. Bonnefoy, H. Spits, T. Yokota, N. Arai, K. Arai, J. Banchereau   +9 more
semanticscholar   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Ultrasound‐Induced Nitric Oxide‐Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime

Advanced Science, EarlyView.
A hollow nanomotor (PM‐HMSN/Arg) propelled by ultrasound‐triggered nitric oxide (NO) was developed. The nanomotor employs a “tethering‐relaxing‐drilling” mechanism to overcome biological barriers, enabling multimodal theranostics of cancer with deep penetration and extended lifetime.
Xue Xu, Jinxu Cao, Yan Mu, Hao Zhang, Ya‐Lei Wang, Mengzhen Chen, Yuce Li, Qian Hua   +7 more
wiley   +1 more source

Sigma-Class Glutathione Transferases (GSTσ): A New Target with Potential for Helminth Control

Tropical Medicine and Infectious Disease
Glutathione transferases (GSTs EC 2.5.1.18) are critical components of phase II metabolism, instrumental in xenobiotics’ metabolism. Their primary function involves conjugating glutathione to both endogenous and exogenous toxic compounds, which increases
Lluvia de Carolina Sánchez Pérez, Rafael A. Zubillaga, Ponciano García-Gutiérrez, Abraham Landa   +3 more
doaj   +1 more source

Migraine-provoking substances evoke periorbital allodynia in mice

The Journal of Headache and Pain, 2019
Background Administration of endogenous mediators or exogenous chemicals in migraine patients provoke early headaches and delayed migraine-like attacks.
Francesco De Logu, Lorenzo Landini, Malvin N. Janal, Simone Li Puma, Francesco De Cesaris, Pierangelo Geppetti, Romina Nassini   +6 more
doaj   +1 more source

A Cross-Sectional Survey of the Association between Bilateral Topical Prostaglandin Analogue Use and Ocular Adnexal Features

PLoS ONE, 2013
We studied the relation between prostaglandin analogue use and ocular adnexal features. We used a prospective, cross-sectional study involving 157 current, 15 past, and 171 never users of prostaglandin analogues.
M. Shah, Grace Lee, Daniel R. Lefebvre, Benjamin P Kronberg, S. Loomis, S. Brauner, Angela V. Turalba, D. Rhee, S. Freitag, L. Pasquale   +9 more
semanticscholar   +1 more source

Harnessing the Immunomodulation of UV‐Exposed Keratinocyte Extracellular Vesicles for Inflammatory Disorder Treatment

Advanced Science, EarlyView.
Adopting a paradigm shift that transforms a known health hazard as a potential therapeutic asset, a novel therapeutic strategy is set out to investigate for inflammatory conditions by leveraging immunosuppressive properties of UV‐irradiated keratinocytes.
Lu Liu, Ding Yang, Jingsen Ji, Gengyou Li, Haoting Chen, Yuying Yao, Chenxing Fu, Fangling Liao, Jinzhao Liu, Yaming Zhang, Zechuan Li, Jing Zhang, Huike Ma, Jingxia Zhao, Ying‐Shi Sun, Weisheng Guo, Weiping Wang   +16 more
wiley   +1 more source

Acetylation of prostaglandin synthase by aspirin.

Proceedings of the National Academy of Sciences of the United States of America, 1975
When microsomes of sheep or bovine seminal vesicles are incubated with [acetyl-3H]aspirin (acetyl salicylic acid), 200 Ci/mol, we observe acetylation of a single protein, as measured by sodium dodecyl sulfate/polyacrylamide gel electrophoresis.
G. Roth, N. Stanford, P. Majerus
semanticscholar   +1 more source

Coactosin‐Like Protein Reduces Prostaglandin D2 Production in Alveolar Macrophages and Alleviates Allergic Airway Inflammation

Advanced Science, EarlyView.
Coactosin‐like protein inhibits prostaglandin D₂ (PGD2) secretion by modulating alveolar macrophage polarization, thereby suppressing activation of the PGD2 receptor CRTH2 in Th2‐associated immune cells and alleviating allergic airway inflammation.
Li‐Long Pan, Zhengnan Ren, Binbin Li, Wenjie Liang, Yang Luo, Qin Yang, He Liu, Xiaoliang Dong, Haizhi Tian, Huimin Zou, Bengt Samuelsson, Olof Rådmark, Jia Sun   +12 more
wiley   +1 more source

Lipid metabolites and nitric oxide production in the cerebrospinal fluid and plasma of dogs with meningoencephalitis of unknown origin and idiopathic epilepsy: a pilot study

Frontiers in Veterinary Science
IntroductionIdiopathic epilepsy (IE) and meningoencephalomyelitis of unknown origin (MUO) are common causes of brain diseases leading to seizures in dogs.
Tomohiro Yonezawa, Tomohiro Yonezawa, Shinya Takenouchi, Tomoki Motegi, Michiyo Miyazaki, Nanae Nagata, Koji Kobayashi, Koji Kobayashi, Masaki Yamada, Takahisa Murata, Takahisa Murata, Takahisa Murata   +11 more
doaj   +1 more source