Horses with equine recurrent uveitis have an activated CD4+ T-cell phenotype that can be modulated by mesenchymal stem cells in vitro. [PDF]
, 2020 Equine recurrent uveitis (ERU) is an immune-mediated disease causing repeated or persistent inflammatory episodes which can lead to blindness. Currently, there is no cure for horses with this disease.
Bellone, Rebecca R +6 more
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15-Deoxy-Δ12,14-prostaglandin J2 inhibits multiple steps in the NF-κB signaling pathway
, 2000 Prostaglandin J2 (PGJ2) and its metabolites Δ12-PGJ2 and 15-deoxy-Δ12,14-PGJ2 (15d-PGJ2) are naturally occurring derivatives of prostaglandin D2 that have been suggested to exert antiinflammatory effects in vivo.
Daniel S. Straus +8 more
semanticscholar +1 more source
Prostaglandins and prostaglandin receptor antagonism in migraine [PDF]
The Journal of Headache and Pain, 2013 Human models of headache may contribute to understanding of prostaglandins' role in migraine pathogenesis. The current thesis investigated the migraine triggering effect of prostaglandin E2 (PGE2) in migraine patients without aura, the efficacy of a novel EP4 receptor antagonist, BGC20-1531, in prevention of PGE2-induced headache and the ability of ...
openaire +3 more sources
Accelerated Bone Healing via Electrical Stimulation
Advanced Science, EarlyView.Electrical stimulation significantly impacts bone healing by enhancing osteoblast proliferation, differentiation, and vascularization through calmodulin/calcineurin/NFAT signaling. It also boosts macrophage function and cell migration, presenting a comprehensive approach to accelerating bone repair.
Jianfeng Sun +4 more
wiley +1 more source
LC/MS/MS method for analysis of E2 series prostaglandins and isoprostanes
Journal of Lipid Research, 2011 15-series prostaglandins (PGE2s) and isoprostanes (isoPGE2s) are robust biomarkers of oxidative stress, possess potent biological activity, and may be derived through cyclooxygenase or free radical pathways.
Stephen A. Brose +2 more
doaj
Transitioning Between Prostanoid Therapies in Pulmonary Arterial Hypertension
Frontiers in Medicine, 2020 Background: New oral prostacyclin therapies and prostacyclin agonists have become available for the treatment of pulmonary arterial hypertension (PAH).
Irene Z. Pan +9 more
doaj +1 more source
Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells.
Cancer Research, 2007 A causative relationship between chronic inflammation and cancer has been postulated for many years, and clinical observations and laboratory experiments support the hypothesis that inflammation contributes to tumor onset and progression.
P. Sinha +3 more
semanticscholar +1 more source
Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles
Advanced Science, EarlyView.Macrophages play a critical role in several pathophysiological diseases by being involved in the activation of adaptive and innate immune responses. The repolarization of macrophages using gold nanoparticles functionalized with glycans for a more selective targeting toward a restorative phenotype leads to an amelioration of the events.
Jennifer Fernandez Alarcon +25 more
wiley +1 more source
Niacin, an old drug with a new twist
Journal of Lipid Research, 2013 Niacin (nicotinic acid) has been used for decades as a lipid-lowering drug. The clinical use of niacin to treat dyslipidemic conditions is limited by its side effects.
Wen-Liang Song, Garret A. FitzGerald
doaj
Studies relating to Polyunsaturated Fatty Acid (PUFA) Supplementation and Fertility in Cattle [PDF]
, 2007 End of project reportReproductive inefficiency has a significant impact on the economic performance of both dairy and beef herds, particularly in seasonal calving systems. Nutrition plays a fundamental role in reproduction. Furthermore, there is emerging
Childs, Stuart +3 more
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