Results 81 to 90 of about 501,484 (388)

Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production [PDF]

open access: yesJournal of Neuroimmunology 174(1-2): 39-51 (2006), 2007
In the present study, we show that ascorbic acid dose-dependently inhibited interleukin-1beta (IL-1beta)-mediated PGE2 synthesis in the human neuronal cell line, SK-N-SH. Furthermore, in combination with aspirin, ascorbic acid augmented the inhibitory effect of aspirin on PGE2 synthesis. However, ascorbic acid had no synergistic effect along with other
arxiv  

Emerging Therapeutic Strategies for Hearing Loss

open access: yesAdvanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han   +9 more
wiley   +1 more source

LC/MS/MS method for analysis of E2 series prostaglandins and isoprostanes

open access: yesJournal of Lipid Research, 2011
15-series prostaglandins (PGE2s) and isoprostanes (isoPGE2s) are robust biomarkers of oxidative stress, possess potent biological activity, and may be derived through cyclooxygenase or free radical pathways.
Stephen A. Brose   +2 more
doaj  

Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells.

open access: yesCancer Research, 2007
A causative relationship between chronic inflammation and cancer has been postulated for many years, and clinical observations and laboratory experiments support the hypothesis that inflammation contributes to tumor onset and progression.
P. Sinha   +3 more
semanticscholar   +1 more source

Accelerated Bone Healing via Electrical Stimulation

open access: yesAdvanced Science, EarlyView.
Electrical stimulation significantly impacts bone healing by enhancing osteoblast proliferation, differentiation, and vascularization through calmodulin/calcineurin/NFAT signaling. It also boosts macrophage function and cell migration, presenting a comprehensive approach to accelerating bone repair.
Jianfeng Sun   +4 more
wiley   +1 more source

Niacin, an old drug with a new twist

open access: yesJournal of Lipid Research, 2013
Niacin (nicotinic acid) has been used for decades as a lipid-lowering drug. The clinical use of niacin to treat dyslipidemic conditions is limited by its side effects.
Wen-Liang Song, Garret A. FitzGerald
doaj  

Urinary eicosanoid metabolites in HIV-infected women with central obesity switching to raltegravir: an analysis from the women, integrase, and fat accumulation trial. [PDF]

open access: yes, 2014
Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects.
Boger, M Sean   +11 more
core   +3 more sources

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

open access: yesAdvanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang   +10 more
wiley   +1 more source

The Effects of Intrauterine Injection with Prostaglandin F2α, Arachidonic Acid and Phosphate Solution on the Eggshell Formation of Japanese Quail Hen

open access: yesThe Journal of Poultry Science, 2002
Inhibitory effects of prostaglandin F2α, arachidonic acid and phosphate solution on the eggshell formation were investigated in Japanese quail. All injections were performed intrauterinely 8h before the predicted oviposition. Prematurely oviposited
Tomoki Soh   +3 more
doaj   +1 more source

Efficacy of Amnitear vs. Conventional Method for Artificial Rupture of Membranes: A Prospective Study [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2018
Introduction: Amnitear is a newer device which is to be worn over gloved index finger for doing artificial rupture of membranes. Aim: To evaluate the efficacy of Amnitear in doing Artificial Rupture of Membrane (ARM) and to compare the efficacy and ...
Nidhi Gupta   +4 more
doaj   +1 more source

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