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Low-dose prostaglandin E1 is safe and effective for critical congenital heart disease: is it time to revisit the dosing guidelines?

Cardiology in the Young, 2020
Introduction: Prostaglandin E1 is used to maintain ductal patency in critical congenital heart disease (CHD). The standard starting dose of prostaglandin E1 is 0.05 µg/kg/minute.
Daniel Vari   +5 more
semanticscholar   +1 more source

Fluorescence of prostaglandin E1

Analytical Chemistry, 1968
The chemical structure of PGE1 (prostaglandin E1) is diagrammed. Because this structure suggested the possibility of several resonance forms of the molecule a study was undertaken to determine their possible fluorescence. The laboratory procedures involved are explained. Increased concentrations of PGE1 were found to produce increased fluorescence.
D. R. Thomas   +3 more
openaire   +3 more sources

Misoprostol: A prostaglandin E1 analogue

American Journal of Health-System Pharmacy, 1989
The pharmacology, pharmacokinetics, clinical efficacy, contraindications and precautions, adverse effects, dosage, and cost of misoprostol are reviewed. Misoprostol is a synthetic analogue of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion and enhances mucosal resistance to injury.
Robert E. Garris, Craig F. Kirkwood
openaire   +3 more sources

Prostaglandin E1 in hand angiography

American Journal of Roentgenology, 1983
Prostaglandin E1 (PGE1) is a rapid, potent vasodilator which, when infused into the arterial system in low doses by bolus injection, has no significant systemic effects and has a relatively long duration of action. Sixty-three hand angiograms were done on 55 patients, comparing PGE1 to tolazoline and to angiograms done with no vasodilation.
Nykamp Pw   +4 more
openaire   +3 more sources

Enzymatic inactivation of 6-keto-prostaglandin E1 in vitro: Comparison with prostaglandin E1

Biochemical Pharmacology, 1984
The inactivation of 6-keto PGE1, a biologically active and stable metabolite of prostacyclin, was studied in 100,000 g cytosolic supernatants by bioassay on rat stomach strip (contraction) and human platelets (inhibition of ADP-induced aggregation). PGE1 was used as a reference compound.
R.J. Griffiths   +3 more
openaire   +3 more sources

Prostaglandin E1 for treatment of erectile dysfunction

Cochrane Database of Systematic Reviews, 2002
Erectile dysfunction (ED), the inability to achieve or maintain an erection sufficient for satisfactory sexual activity, is one of the most common sexual dysfunctions in men. ED may have a dramatic impact on the quality of life of many men and their partners.The aim of this systematic review was to evaluate and summarise the effectiveness and safety of
Urciuoli R.   +4 more
openaire   +4 more sources

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