Results 241 to 250 of about 252,911 (302)
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Prostaglandin E1 induced salivary secretion
Experientia, 1982PGE1 but not PGF2α at 500–1000 μg/kg induced a slow and sparse flow from the parotid and no flow at all from submaxillary glands. Composition of PGE1-induced parotid saliva was quite different from that evoked by any autonomic agonists. The present study suggests that PGE1 might act directly on parotid acinar cells.
J H, Yu, S, Burns, C A, Schneyer
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Enzymatic inactivation of 6-keto-prostaglandin E1 in vitro: Comparison with prostaglandin E1
Biochemical Pharmacology, 1984The inactivation of 6-keto PGE1, a biologically active and stable metabolite of prostacyclin, was studied in 100,000 g cytosolic supernatants by bioassay on rat stomach strip (contraction) and human platelets (inhibition of ADP-induced aggregation). PGE1 was used as a reference compound.
C N, Berry +3 more
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Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 1988
Work on the structure of prostaglandin E1 (PGE1), isolated from natural sources, was completed 25 years ago (1). Shortly after, methods for the chemical synthesis of PG with their natural configuration were developed in the laboratories of the UpJohn Company (2) and of E. J. Corey (3) and, by the late sixties, PGE1 became widely available.
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Work on the structure of prostaglandin E1 (PGE1), isolated from natural sources, was completed 25 years ago (1). Shortly after, methods for the chemical synthesis of PG with their natural configuration were developed in the laboratories of the UpJohn Company (2) and of E. J. Corey (3) and, by the late sixties, PGE1 became widely available.
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Prostaglandins, 1983
Abstract In the last three years a considerable amount of interest has been shown in the biosynthesis and pharmacological activity of a novel metabolite of prostacyclin (PGI2) called 6-keto-prostaglandin-E1 (6-keto-PGE1). The possibility that biosynthesis of 6-keto-PGE1 may contribute to some of the biological effects of either injected or endogenous
Philip K. Moore, Richard J. Griffiths
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Abstract In the last three years a considerable amount of interest has been shown in the biosynthesis and pharmacological activity of a novel metabolite of prostacyclin (PGI2) called 6-keto-prostaglandin-E1 (6-keto-PGE1). The possibility that biosynthesis of 6-keto-PGE1 may contribute to some of the biological effects of either injected or endogenous
Philip K. Moore, Richard J. Griffiths
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Prostaglandin E1-induced latent epileptogenic foci
Electroencephalography and Clinical Neurophysiology, 1979Suprafusion of 125 microliter 6% KCl solution over the visual cortex of rabbits 2-24 h after they suffered a prostaglandin (PG) E1-induced epileptic seizure was found to cause a recurrence of seizure activity. The initial seizure was induced by the cortical suprafusion of PGE1 over the left visual cortex of PG transport inhibitor-pretreated rabbits ...
M C, Wallenstein, L Z, Bito
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Prostaglandin E1 decreases circulating endothelial cells
Prostaglandins, 1996Prostaglandin E1 (PGE1) has been claimed to have cytoprotective effects and also to decrease thrombogenicity. The effect of intraarterial (i.a.) and intravenous (i.v.) administration of PGE1 on the number of circulating endothelial cells (CEC) was investigated in patients with peripheral vascular disease (PVD).
H, Sinzinger +4 more
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Pharmacological Erection Program Using Prostaglandin E1
Journal of Urology, 1991A total of 72 impotent patients entered into a pharmacological erection program using prostaglandin E1. Of the men 35 (49%) used prostaglandin E1 on a regular basis, while 37 (51%) failed to continue in the program beyond the in-office dose titration period.
G S, Gerber, L A, Levine
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Intracavernous prostaglandin E1 in erectile dysfunction
Journal of Molecular Medicine, 1994Prostaglandin E1 (PGE1) is a naturally occurring substance that is present in a variety of mammalian tissues, including the semen of fertile men. Its use in the diagnosis and treatment of erectile dysfunction has been extensively studied. In doses of 10-20 micrograms, PGE1 produces full erections in 70-80% of patients with erectile dysfunction.
O I, Linet, L L, Neff
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Papaverine plus prostaglandin E1 versus prostaglandin E1 alone for intracorporeal injection therapy
International Urology and Nephrology, 1998A study comparing intracorporeal injection of prostaglandin E1 (one-drug solution) and papaverine plus prostaglandin E1 (2-drug solution) for treatment of impotence.A total of 100 impotent patients had intracorporeal injections of the one-drug and 2-drug solution alternatively in 3 sessions.
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Prostaglandin E1 metabolism by human plasma
Prostaglandins, 1972Abstract An enzymic prostaglandin E1 metabolising system in human plasma is described. Various properties of the system have been investigated. Metabolism of prostaglandin E1 added to whole human blood or plasma, particularly in low concentrations such as those found physiologically, can be extremely rapid and extensive.
W J, McDonald-Gibson +2 more
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