Results 121 to 130 of about 373,954 (298)

Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease

Annals of Neurology, 2012
There is significant evidence for a central role of inflammation in the development of Alzheimer disease (AD). Epidemiological studies indicate that chronic use of nonsteroidal anti‐inflammatory drugs (NSAIDs) reduces the risk of developing AD in healthy
Ju Shi, Qian Wang, J. Johansson, Xibin Liang, N. Woodling, Prachi G. Priyam, Taylor Loui, M. Merchant, R. Breyer, T. Montine, K. Andreasson   +10 more
semanticscholar   +1 more source

mRNA expression and antilipolytic role of phosphodiesterase 4 in rat adipocytes in vitro

Journal of Lipid Research, 2007
Adipocyte lipolysis is dependent on an increase in the intracellular concentration of cAMP. Intracellular phosphodiesterases (PDEs) hydrolyze cAMP and limit stimulation of lipolysis.
Wang Hong, Neilé K. Edens
doaj  

Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]

, 2007
Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Angioni, Carlo Federico, Becker, Wiebke, Brenneis, Christian, Coste, Ovidiu, Geisslinger, Gerd, Nusing, Rolf M., Popp, Laura, Schmidt, Ronald, Scholich, Klaus   +8 more
core   +1 more source

Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2

Proceedings of the National Academy of Sciences of the United States of America, 2012
With interest waning in the use of cyclooxygenase-2 (COX-2) inhibitors for inflammatory disease, prostaglandin receptors provide alternative targets for the treatment of COX-2–mediated pathological conditions in both the periphery and the central nervous
Jianxiong Jiang, T. Ganesh, Yuhong Du, Yi Quan, G. Serrano, Min Qui, Iris A. Speigel, A. Rojas, N. Lelutiu, R. Dingledine   +9 more
semanticscholar   +1 more source

The role of cyclooxygenase-2 (COX-2) and inflammatory markers in the progress of Alport syndrome in Egyptian children

BMC Pediatrics
Background Chronic inflammation and its control are crucial to the responses of glomerular and renal tubular cells. This contributes to the pathogenic mechanisms and advancement of the disease in Alport syndrome.
Moushira Zaki, Hisham A. Orban, Mohamed A. Shahba, Rehab S. I. Moustafa, Ahmed Adel, Fatina I. Fadel, Abeer Selim, Hala T. El-Bassyouni, Eman R. Youness   +8 more
doaj   +1 more source

Hyperforin, an anti-inflammatory constituent from St. John’s wort, inhibits microsomal prostaglandin E2 synthase-1 and suppresses prostaglandin E2 formation in vivo

Frontiers in Pharmacology, 2011
The acylphloroglucinol hyperforin (Hyp) from St. John’s wort possesses anti-inflammatory and anti-carcinogenic properties which were ascribed among others to the inhibition of 5-lipoxygenase.
Andreas eKoeberle, Andreas eKoeberle, Antonietta eRossi, Julia eBauer, Friederike eDehm, Luisella eVerotta, Hinnak eNorthoff, Lidia eSautebin, Oliver eWerz   +8 more
doaj   +1 more source

Attenuation of ischemic liver injury by prostaglandin E1 analogue, misoprostol, and prostaglandin I2 analogue, OP-41483 [PDF]

, 1998
Background: Prostaglandin has been reported to have protective effects against liver injury. Use of this agent in clinical settings, however, is limited because of drugrelated side effects.
Ishizaki, N, Jin, MB, Kawashima, Y, Shimamura, T, Starzl, TE, Todo, S, Totsuka, E, Urakami, A, Zhu, Y   +8 more
core   +1 more source

Prostaglandin E2 is raised in kwashiorkor.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2002
Infection is a common occurrence in children with kwashiorkor. It has been suggested that infection in kwashiorkor results from immune depression, and that the immune depression of kwashiorkor is caused by a diet-associated elevation of prostaglandin E2 (PGE2).
Iputo, JE, Sammon, A M, Tindimwebwa, G
openaire   +2 more sources

Induction of Abortion by Prostaglandins E1 and E2 [PDF]

BMJ, 1970
Intravenous infusions of prostaglandin E (E(1) or E(2)) were used for termination of pregnancy in 11 patients. Induction of abortion was successful in nine instances and in eight the abortion was complete. No undesirable side-effects were recorded.
openaire   +3 more sources

An observational study comparing two regimens of PGE2 gel for pre-induction cervical ripening at term [PDF]

New Indian Journal of OBGYN
Objectives: The objective of this study was to compare the outcome in between two groups, one group receiving a 6 hourly repeat regimen (maximum 2 such) and another group receiving a 12 hourly repeat regimen of prostaglandin E 2 gel (maximum 2 such ...
Nishat Parveen Begg, Shelley Seth, Aparna Khan Mandal   +2 more
doaj   +1 more source