Results 121 to 130 of about 77,658 (288)

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

British Journal of Pharmacology, EarlyView.
Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti, Valentin Varga, Erda Qorri, Rita Frank, Diana Kata, Krisztián Vinga, Péter Archibald Szarvas, Ákos Menyhárt, Károly Gulya, Ferenc Bari, Eszter Farkas   +10 more
wiley   +1 more source

Connexin43 Promotes the Invasion and Metastasis of Lung Squamous Cell Carcinoma via GJIC‐Dependent Ca2+/ERK Signaling Activation

Cancer Science, EarlyView.
Cx43 mediated GJIC‐dependent delivery of second messenger Ca2+ thus activating the ERK signaling pathway. Verapamil, effective effectively inhibits these pathways. ABSTRACT Lung squamous cell carcinoma (LUSC) is an extremely metastatic cancer with limited available treatment and poor outcomes.
Xiaocheng Mo, Jingchuan He, Xiaoju Shen, Changsheng Li, Xiaoxiang Mo, Kai Liang, Liangjun He, Tingting Li, Xiaoqin Pan, Sisi Cao, Naiquan Mao, Shangping Xing, Zhiquan Chen, Zhuo Luo, Jie Yang   +14 more
wiley   +1 more source

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Cell Proliferation, EarlyView.
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen, Haijun Zhang, Zhaoheng Wang, Daxue Zhu, Yanhu Li, Yizhi Zhang, Dongxin Wang, Shuwei Chen, Huan Liu, Xuewen Kang   +9 more
wiley   +1 more source

Pulmonary surfactant and prostaglandin E2 in airway smooth muscle relaxation of human and male guinea pigs

Physiological Reports
Pulmonary surfactant serves as a barrier to respiratory epithelium but can also regulate airway smooth muscle (ASM) tone. Surfactant (SF) relaxes contracted ASM, similar to β2‐agonists, anticholinergics, nitric oxide, and prostanoids. The exact mechanism
J. Hanusrichterova, M. Kolomaznik, R. Barosova, J. Adamcakova, D. Mokra, J. Mokry, H. Skovierova, M. M. Kelly, E. deHeuvel, S. Wiehler, D. Proud, H. Shen, P. G. Mukherjee, M. W. Amrein, A. Calkovska   +14 more
doaj   +1 more source

The Emerging Therapeutic Role of Prostaglandin E2 Signaling in Pulmonary Hypertension. [PDF]

Metabolites, 2023
Ye L, Wang B, Xu H, Zhang X.
europepmc   +1 more source

Influence of Prostaglandins E1, E2, and Arachidonate on Melanosomes in Melanocytes and Keratinocytes of Anagen Hair Bulbs in Vitro

, 1975
John J. Sauk, James G. White, Carl J. Witkop   +2 more
openalex   +1 more source

Medial femorotibial and femoropatellar articular cartilage delamination following intra‐articular therapy with triamcinolone and gentamicin in five yearlings

Equine Veterinary Education, EarlyView.
Summary Subchondral lucencies (SCLs) of the medial femoral condyle (MFC) are a cause of lameness in young horses, potentially affecting future athletic performance. Due to the widespread use of pre‐sales screening radiographs for Thoroughbred weanlings and yearlings, these lesions are frequently identified at various stages of progression without the ...
C. P. Beggan, G. C. Quinn, C. W. McIlwraith   +2 more
wiley   +1 more source

Specific inhibition by prostaglandins E2 and I2 of histamine-stimulated [14C]aminopyrine accumulation and cyclic adenosine monophosphate generation by isolated canine parietal cells. [PDF]

, 1980
Andrew H. Soll
openalex   +1 more source

Synthesis of Prostaglandins F2α and E2 [PDF]

Synfacts, 2018
Erick M. Carreira, Helene Wolleb
openaire   +1 more source

Single injection of intra‐articular autologous protein solution in horses with acute interleukin‐1B‐induced synovitis decreases joint pathology scores

Equine Veterinary Journal, Volume 57, Issue 3, Page 806-816, May 2025.
Abstract Background Autologous protein solution (APS) has been shown to decrease lameness in horses with osteoarthritis (OA). Synovitis is an early driver of OA, providing an opportunity to intervene in the progression of disease via intra‐articular (IA) therapeutics.
Alexandra Usimaki, Sarah A. Ciamillo, Dhvani Barot, Renata L. Linardi, Julie B. Engiles, Kyla F. Ortved   +5 more
wiley   +1 more source