Results 211 to 220 of about 143,781 (307)

Prostaglandin E₂-driven dedifferentiation of Schwann cells leads to perineural invasion in pancreatic ductal adenocarcinoma. [PDF]

Signal Transduct Target Ther
Wang L, Liu Q, Zhang Z, Yang S, Tang J, Pan G, Zheng Y, Zhuang Y, Wu Q, Weng S, Gao F, Dong J.   +11 more
europepmc   +1 more source

SCD1 Regulates Osteoclast Differentiation by Modulating Arachidonic Acid Metabolism and Mitochondrial Homeostasis

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
This graphical abstract illustrates that SCD1 inhibition by A939572 or the targeted nanovesicle POCM‐NP@A939572 reprograms arachidonic acid metabolism via the COX1‐HPGDS‐PGD2 axis and impairs mitochondrial homeostasis, thereby suppressing osteoclastogenesis and alleviating bone loss in osteoporosis.
Yihao Zhao, Xiaoan Wei, Haihao Wu, Chengjun Yao, Zeyu Zheng, Weishao Chen, Zhenhua Feng, Bao Huang, Zimin Cai, Qize Xue, Jian Chen, Fengdong Zhao, Junhui Liu   +12 more
wiley   +1 more source

Anti-Inflammatory Lindolin Alkaloids Repress the Transcription of the Microsomal Prostaglandin E₂ Synthase-1 Gene in Macrophages. [PDF]

J Nat Prod
Jordan PM, Rassbach J, Gräfe M, Peltner LK, Willing K, Zenkel L, Günther K, Sonnabend R, Regestein L, Werz O, Gressler M.   +10 more
europepmc   +1 more source

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, Volume 16, Issue 5, Page 857-869, May 2026.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Molecular basis of prostaglandin E₂ reuptake by organic anion transporter PGT. [PDF]

Nat Commun
Zhu Z, Li Y, Xia H, Yang C, Zhou Z, Chao Y, Ba Q, Li D, Qu Q.   +8 more
europepmc   +1 more source

Elevated Serum Proadrenomedullin Levels in Rheumatoid Arthritis Versus Spondyloarthritis: Insights From a Biobank Cohort

ACR Open Rheumatology, Volume 8, Issue 5, May 2026.
Objective Proadrenomedullin (pro‐ADM) is a peptide implicated in immunomodulation, with higher levels observed in inflammatory conditions, cardiovascular impairment, and sepsis. Although extensively studied in acute disorders, its potential as a biomarker in inflammatory arthritis remains underexplored.
Nefeli Stavroula Papastathopoulou, Elisa Assirelli, Simona Neri, Susanna Naldi, Jacopo Ciaffi, Luana Mancarella, Veronica Brusi, Lucia Lisi, Federica Pignatti, Piero Ruscitti, Francesco Ursini   +10 more
wiley   +1 more source

The ins and outs of prostaglandin E2 in fever [PDF]

Temperature, 2015
openaire   +2 more sources

Tumor Anti‐Angiogenesis Therapy and Its Influence on Immune Cell Function in the Tumor Microenvironment

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Vascular normalization, one promising anti‐angiogenic strategy, has the potential to enhance vascular perfusion and elevate the infiltration of immune cells into tumors by rectifying aberrant tumor blood vessels. This results in the enhancement of immunotherapy.
Yu Tang, Yuyan Ding, LiPing Wang, Yujiao Yang, Youwei Han, Peng Zhou, Huiheng Qu, Kaiyuan Deng, Jiazeng Xia   +8 more
wiley   +1 more source

Urinary Prostaglandin E2 Excretion and the Risk of Cardiovascular and Kidney Disease. [PDF]

J Am Heart Assoc
Geurts F, Chaker L, van der Burgh AC, Cronin-Fenton D, Fenton RA, Hoorn EJ.   +5 more
europepmc   +1 more source