Results 231 to 240 of about 214,655 (309)

The Kv2.2 channel mediates the inhibition of prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells. [PDF]

Elife
Pan C, Liu Y, Wang L, Fan WY, Ni Y, Zhang X, Wu D, Li C, Li J, Li Z, Liu R, Hu C.   +11 more
europepmc   +1 more source

TRIP8bnano peptide prevents cAMP binding to HCN2 channels alleviating pain‐like behaviors in rats with neuropathic pain

The Journal of Physiology, EarlyView.
Abstract figure legend We tested the hypothesis that cAMP binding to HCN2 channels in nociceptors is a causal driver of neuropathic pain by using TRIP8bnano, a synthetic peptide we previously developed as a selective antagonist of cAMP in HCN channels. TRIP8bnano effectively abolishes cAMP potentiation of HCN2 currents in small‐diameter DRG neurons and
Santiago I. Loya‐Lopez, Kimberly Gomez, Alessandro Porro, Gerhard Thiel, Anna Moroni, Heather N. Allen, Rajesh Khanna, Andrea Saponaro   +7 more
wiley   +1 more source

Ubiquitin-specific peptidase 20 affects immune cell infiltration by regulating prostaglandin E2 on intraperitoneal metastasis model of colorectal cancer. [PDF]

Transl Cancer Res
Hua Y, Ma X, Zhao X, Wei X, Mu X, Wang B, Yuan X.   +6 more
europepmc   +1 more source

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Structural insights into the activation of the human prostaglandin E₂ receptor EP1 subtype by prostaglandin E₂. [PDF]

Proc Natl Acad Sci U S A
Meng X, Li Y, Xu J, Wu K, Hu W, Wu C, Xu HE, Xu Y.   +7 more
europepmc   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, Volume 101, Issue 5, Page 2265-2278, October 2026.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

Elevated pyramidal cell firing orchestrates arteriolar vasoconstriction through COX-2-derived prostaglandin E2 signaling. [PDF]

Elife
Le Gac B, Tournissac M, Belzic E, Picaud S, Dusart I, Soula H, Li D, Charpak S, Cauli B.   +8 more
europepmc   +1 more source

Effect of Vaping on Treatment Outcomes in Patients With Gingivitis, Periodontitis, and/or Peri‐Implant Disease: A Systematic Review

Clinical and Experimental Dental Research, Volume 12, Issue 5, October 2026.
ABSTRACT Objective This systematic review aimed to evaluate the effect of vaping on periodontal treatment outcomes for patients with gingivitis, periodontitis, and/or peri‐implant disease. Material and Methods An electronic database search was conducted using Ovid MEDLINE, PubMed, Scopus, and Web of Science, with no date restrictions.
Stacey May Gould, Catherine Anne Gilchrist, Hannah Dominique Gaza, Ibadat Kaur Sidhu, Kayleigh Jade Hugo, Rodrigo Rodrigues Amaral, João Martins de Mello‐Neto   +6 more
wiley   +1 more source

Novel Pyrazole‐4‐Carbaldehyde Derivatives Having Potent COX‐2 Inhibition and Anti‐Tubercular Activity: Microwave‐Assisted Green Synthesis and Molecular Docking

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
ABSTRACT A series of 1‐(4‐Chorophenyl)‐3Aryl‐1‐H‐pyrazole‐4‐carbaldehyde derivatives were synthesized under the microwave irradiation (MW) technique. IR, 1H‐NMR, 13C‐NMR, and mass spectroscopic techniques were used to confirm the structure of the synthesized compounds.
Megha Kokane, Dnyandev Bhosale, Dattatraya Raut, Pushpa Hadimani, Ashwini Narale, Prafulla Choudhari, Anjana Lawand   +6 more
wiley   +1 more source

The Functional Study of Prostaglandin E₂ via EP Receptor on Pacemaker Activity in Interstitial Cells of Cajal from Murine Colon. [PDF]

Chonnam Med J
Gong H, Jiao HY, Chang Y, Choi S, Hong CS, Jun JY.   +5 more
europepmc   +1 more source