Results 241 to 250 of about 214,655 (309)

Post‐Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management

MedComm, Volume 7, Issue 10, October 2026.
A comprehensive review on post‐tuberculosis lung disease (PTLD) addresses the epidemiology, pathogenesis, clinical phenotypes and management, risk factors, prevention and systems approach, and future directions. This review provides standardized definitions, mechanistic insights and biomarkers of PTLD development, and clinical strategies for PTLD ...
Radha Gopalaswamy, Selvakumar Subbian
wiley   +1 more source

Inhibition of COX‐2‐Mediated Arachidonic Acid Metabolism by FGF21‐PPARα Axis Alleviates Liver Steatosis

MedComm, Volume 7, Issue 10, October 2026.
Under physiological conditions, the FGF21‐PPARα axis restrains COX‐2 and maintains arachidonic acid (AA) metabolic homeostasis. During steatotic liver disease, ERK1/2 phosphorylation increases alongside adaptive FGF21/PPARα activation, which is insufficient to suppress COX‐2, leading to COX‐driven AA remodeling, PGE2 accumulation, inflammation, and ...
Guangsen Xu, Tingting Pan, Guiyun Wang, Feng Qiu, Junlin Leng, Qiyang Feng, Yongguo Xue, Ye Wang, Junwei Zheng, Huiying Lu, Bingyan Han, Suntao Wang, Jie Du, Jiaojian Lv, Baile Wang, Xuebo Pan   +15 more
wiley   +1 more source

Disruption of primary ciliary prostaglandin E₂ signaling by transforming growth factor-β1 impairs endometrial receptivity. [PDF]

J Biomed Sci
Hou HT, Li WN, Lin TC, Lin CW, Pan PH, Lee CJ, Chen YC, Chen PF, Wang CY, Wu MH, Tsai SJ.   +10 more
europepmc   +1 more source

Association Between the Root Canal Microbiome and Apical Lesion Size: An Observational Shotgun Metagenomic Study

International Endodontic Journal, Volume 59, Issue 10, Page 2211-2222, October 2026.
ABSTRACT Aim The aim was to characterize the taxonomic and functional composition of the microbiome involved in primary endodontic infections and to evaluate their association with the periapical lesion size using shotgun metagenomic sequencing. Methodology Samples from primary root canal infections diagnosed with apical periodontitis were analysed ...
Virginia Pérez‐Carrasco, David Uroz‐Torres, Ana Soriano‐Lerma, Miguel Soriano, Jose Antonio García‐Salcedo, Maria Teresa Arias‐Moliz   +5 more
wiley   +1 more source

Cyclooxygenase-2/prostaglandin E2 inhibition remodulated photodynamic therapy-associated immunosuppression for enhanced cancer immunotherapy. [PDF]

Mater Today Bio
Xu T, Liu K, Mi S, Yao Y, Zhang M, Xue S, Zhi F, Cryan SA, Ding D.   +8 more
europepmc   +1 more source

Relaxin‐2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín, Lucía Gómez‐Cibeira, Javier García‐Seara, Pablo de la Fuente‐López, Carlos Minguito‐Carazo, Susana B. Bravo, Manuel Otero‐Santiago, Oreste Gualillo, José Ramón González‐Juanatey, Francisca Lago, Sandra Feijóo‐Bandín, Alana Aragón‐Herrera   +11 more
wiley   +1 more source

Urinary Prostaglandin E2 Excretion and the Risk of Cardiovascular and Kidney Disease. [PDF]

J Am Heart Assoc
Geurts F, Chaker L, van der Burgh AC, Cronin-Fenton D, Fenton RA, Hoorn EJ.   +5 more
europepmc   +1 more source

Photoredox/Pyridine N‐Oxide Catalyzed Acyl Radical Generation From Aldehydes for Divergent Synthesis of Pyrroles and Carbocyclic Ketones

Advanced Synthesis &Catalysis, Volume 368, Issue 18, 19 September 2026.
Pyridine N‐oxides serve as photoinduced HAT catalysts to convert simple aldehydes into acyl radicals catalyzed by organophotocatalysts. Reacting these intermediates with alkynes opens aldehyde‐dependent pathways to densely functionalized pyrroles, substituted cyclopentanones, and indanones.
Saranya Vadakke Poikayil Sasi, Lindsey Soruco, Yongming Deng   +2 more
wiley   +1 more source

Prostaglandin E2 affects mitochondrial function in adult mouse cardiomyocytes and hearts. [PDF]

Prostaglandins Leukot Essent Fatty Acids
Bryson TD, Zurek M, Moore C, Taube D, Datta I, Levin A, Harding P.   +6 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, Volume 16, Issue 9, Page 1825-1839, September 2026.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source