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Pharmacogenetics and Genomics, 2007
Prostaglandin synthesis is the primary target of aspirin and other nonsteroidal antiinflammatory drugs, and thus is a pathway of major interest to pharmacology, pharmacogenetics, and epidemiology. Several lines of evidence implicate prostaglandin E2 in carcinogenesis; this study aimed to identify genetic variants in genes related to prostaglandin E2 ...
Jeannette, Bigler +5 more
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Prostaglandin synthesis is the primary target of aspirin and other nonsteroidal antiinflammatory drugs, and thus is a pathway of major interest to pharmacology, pharmacogenetics, and epidemiology. Several lines of evidence implicate prostaglandin E2 in carcinogenesis; this study aimed to identify genetic variants in genes related to prostaglandin E2 ...
Jeannette, Bigler +5 more
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Roles of prostaglandin E2 in the cochlea
Hearing Research, 2011Prostaglandins are one of the major groups of chemical mediators in the mammalian body. Among prostaglandins, prostaglandin E2 (PGE2) is the most abundant prostanoid in humans and involved in regulating many different fundamental biological functions. PGE2 signaling is mediated by four distinct E-prostanoid receptors (EPs) namely EP1-4.
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1995
Prostaglandin E2 is the most common and biologically potent of the primary prostaglandins. It induces contraction of uterine smooth muscle at all stages of pregnancy and is used principally to induce labour or as an abortifacient. It has vasodilator and bronch-odilator properties. It can be given by vaginal, oral and parenteral routes.
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Prostaglandin E2 is the most common and biologically potent of the primary prostaglandins. It induces contraction of uterine smooth muscle at all stages of pregnancy and is used principally to induce labour or as an abortifacient. It has vasodilator and bronch-odilator properties. It can be given by vaginal, oral and parenteral routes.
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Journal of Endocrinology, 1983
Intravenous injection of 6·7–60 μg of a stable prostaglandin E2 analogue, 16,16-dimethyl prostaglandin E2, into 10-day-old chicks caused profound, long-lasting hypercalcaemia. Simultaneous i.v. loading with 50 μmol Ca/bird enhanced the peak response. The responses were accompanied by sedation and lowered skin temperature.
G C, Kirby, C G, Dacke
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Intravenous injection of 6·7–60 μg of a stable prostaglandin E2 analogue, 16,16-dimethyl prostaglandin E2, into 10-day-old chicks caused profound, long-lasting hypercalcaemia. Simultaneous i.v. loading with 50 μmol Ca/bird enhanced the peak response. The responses were accompanied by sedation and lowered skin temperature.
G C, Kirby, C G, Dacke
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Production of Prostaglandin E2 by Macrophages in Uraemia
Nephrology Dialysis Transplantation, 1991Production of prostaglandin E2 (PGE2), interleukin-2, and response to lectin stimulation were examined in peripheral blood mononuclear cell cultures from 46 patients on haemodialysis, 20 patients on continuous peritoneal dialysis, 18 non-dialysed patients with mild to moderate renal failure, and 52 control subjects.
E, Langhoff, H, Blaehr, J, Ladefoged
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Synthesis of Prostaglandin E2 In Rat Liver
Pharmacological Research, 1993We have investigated whether rat liver microsomes can release prostaglandins and determined the 'optimal conditions' for the in vitro synthesis of PGE2. We also studied the effect of the oral administration of indomethacin, piroxicam and ibuprofen on PGE2 release ex vivo. The drugs were administered to animals at high doses for one or three consecutive
L, Franco, I, Erbetti, G P, Velo
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The hyperalgesic effects of prostacyclin and prostaglandin E2
Prostaglandins, 1978Hyperalgesia induced in rat paws or dog knee joints by prostacyclin (PGI2) and prostaglandin E2 was measured by a modification of the Randall-Selitto method (1) or by the degree of incapacitation (2). In both species PGI2 induced an immediate hyperalgesic effect but the effect of PGE2 had a longer latency.
S H, Ferreira +2 more
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[Cerebrovascular effects of GABA-prostaglandin E2 conjugate in comparison with prostaglandin E2].
Eksperimental'naia i klinicheskaia farmakologiia, 2013Experiments have shown that GABA conjugate with prostaglandin E2 enhances cerebral blood flow in rats after global transient ischemia, while not affecting the cerebral hemoperfusion in intact animals. It is established that cerebrovascular activity of the GABA conjugate with prostaglandin E2 under conditions of cerebral ischemia is based on GABAergic ...
A V, Gorbunova +4 more
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1995
Treatment of plasma samples by high pH (10-11) can be used to convert the major prostaglandin E2 metabolite, 13,14-dihydro-15-keto-prostaglandin E2, and chemically formed dehydrate derivatives to 11-deoxy-13,14-dihydro-15-keto-11 β, 16e-cycloprosta-glandin E2.
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Treatment of plasma samples by high pH (10-11) can be used to convert the major prostaglandin E2 metabolite, 13,14-dihydro-15-keto-prostaglandin E2, and chemically formed dehydrate derivatives to 11-deoxy-13,14-dihydro-15-keto-11 β, 16e-cycloprosta-glandin E2.
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