Results 271 to 280 of about 373,954 (298)
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The antidipsogenic action of peripheral prostaglandin E2
Pharmacology Biochemistry and Behavior, 1981Intraperitoneal (IP) injection of 50 micrograms/kg prostaglandin E2 (PGE2) suppresses water intake elicited by cellular dehydration, intracerebroventricular injection of angiotensin II (A II) and, for a shorter duration, water deprivation. At a dose of 100 micrograms/kg, IP PGE2 reduces drinking to all of these stimuli as well as to hypovolemia.
K.M. Skoog +2 more
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Phosphatidylethanolamide derivatives of prostaglandins E1 and E2
Prostaglandins, 1976Prostaglandins E1 (PGE1) and E2 (PGE2) have been coupled with the amine group of phosphatidylethanolamine (PE) by means of dicyclohexylcarbodiimide. These complexes basically mimic the relaxant and contractile effects of the corresponding free prostaglandins (PGs) on various smooth muscle preparations, but exhibit a delayed onset of action and a lower ...
E. Bohn, H. Kunze, D. Le-Kim, R.B. Ghooi
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Synthesis of Prostaglandin E2 In Rat Liver
Pharmacological Research, 1993We have investigated whether rat liver microsomes can release prostaglandins and determined the 'optimal conditions' for the in vitro synthesis of PGE2. We also studied the effect of the oral administration of indomethacin, piroxicam and ibuprofen on PGE2 release ex vivo. The drugs were administered to animals at high doses for one or three consecutive
I. Erbetti, Luigina Franco, G. P. Velo
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1995
Treatment of plasma samples by high pH (10-11) can be used to convert the major prostaglandin E2 metabolite, 13,14-dihydro-15-keto-prostaglandin E2, and chemically formed dehydrate derivatives to 11-deoxy-13,14-dihydro-15-keto-11 β, 16e-cycloprosta-glandin E2.
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Treatment of plasma samples by high pH (10-11) can be used to convert the major prostaglandin E2 metabolite, 13,14-dihydro-15-keto-prostaglandin E2, and chemically formed dehydrate derivatives to 11-deoxy-13,14-dihydro-15-keto-11 β, 16e-cycloprosta-glandin E2.
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Preparation of ent-Prostaglandin E2
Tetrahedron, 2000Abstract The enantiomeric prostaglandins, exemplified by ent-PGE2, are apparently produced in vivo by the nonenzymatic oxidation of arachidonic acid. To assess the physiological activity of ent-PGE2, it was necessary to prepare it by total synthesis. The key transformation in this synthesis was the equilibration of the kinetically prepared ent-15-E2t-
Qin Jiang, Douglass F. Taber
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Induction of labor with oral prostaglandin E2
American Journal of Obstetrics and Gynecology, 1976Prostaglandin E (PGE2) was administered orally for induction of labor to 100 patients. Active labor and progression occurred in 92 per cent of these cases. The dosage regimen used was 0.5 to 1.5 mg. hourly. Amniotomy was performed in most cases once active labor and progression were noted.
Bryant J. Brown +2 more
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Prostaglandin E2 Promotes Colon Cancer Cell Growth Through a Gs-Axin-ß-Catenin Signaling Axis
Science, 2005How cyclooxygenase-2 (COX-2) and its proinflammatory metabolite prostaglandin E2 (PGE2) enhance colon cancer progression remains poorly understood.
M. Castellone +4 more
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The role of prostaglandin E2 in endometriosis
Gynecological Endocrinology, 2012Endometriosis is a leading cause of infertility in women of reproductive age. It involves the occurrence of endometrial tissue outside the uterine endometrium, mainly in the peritoneal cavity.
K. Sacco +4 more
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Prostaglandin E2 localization in the rat ileum
The Histochemical Journal, 1992The application of anti-prostaglandin E2 immunoglobulin to plastic-embedded thin sections of the rat ileum has permitted the localization of prostaglandin E2 in this tissue. In agreement with the published data (Chock & Schmauder-Chock (1988), Schmauder-Chock & Chock (1989)), the results also suggest the presence of an arachidonic acid cascade in the ...
Elsa A. Schmauder-Chock +1 more
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Prostaglandin E2 and rat liver regeneration
Gastroenterology, 1993Prostaglandin (PG) is reported to be involved in hepatic regeneration. However, little is known about the detailed relation in PG-induced stimulation of the proliferation. The present study was attempted to elucidate the relation.The serial change of PGE2 level released from the regenerating rat liver and the effect of PGE2 on the proliferation of rat ...
Hiroshi Nakano +4 more
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