AGING MEDICINE, EarlyView.Pogostemon cablin Benth. (PCEE) is a promising antiaging agent that inhibits ROS, decreases the senescence‐associated β‐galactosidase (SA‐β‐gal) gene, and maintains telomere length in doxorubicin‐induced 3T3‐L1 fibroblast cells. The researchers extend their gratitude to www.freepik.com for providing Figure telomer.
Teguh Santoso +6 more
wiley +1 more source
Evidence that the E2-isoprostane, 15-E2t-isoprostane (8-iso-prostaglandin E2) is formed in vivo
Journal of Lipid Research, 1998 D2/E2-isoprostanes are prostaglandin D2/E2-like compounds that are produced in vivo as non-enzymatic products of free radical catalyzed peroxidation of arachidonic acid.
Jason D. Morrow +4 more
doaj
Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production [PDF]
Journal of Neuroimmunology 174(1-2): 39-51 (2006), 2007 In the present study, we show that ascorbic acid dose-dependently inhibited interleukin-1beta (IL-1beta)-mediated PGE2 synthesis in the human neuronal cell line, SK-N-SH. Furthermore, in combination with aspirin, ascorbic acid augmented the inhibitory effect of aspirin on PGE2 synthesis. However, ascorbic acid had no synergistic effect along with other
arxiv
Modular End-to-end Automatic Speech Recognition Framework for Acoustic-to-word Model [PDF]
arXiv, 2020 End-to-end (E2E) systems have played a more and more important role in automatic speech recognition (ASR) and achieved great performance. However, E2E systems recognize output word sequences directly with the input acoustic feature, which can only be trained on limited acoustic data.
arxiv
Exploring Non-Autoregressive End-To-End Neural Modeling For English Mispronunciation Detection And Diagnosis [PDF]
arXiv, 2021 End-to-end (E2E) neural modeling has emerged as one predominant school of thought to develop computer-assisted language training (CAPT) systems, showing competitive performance to conventional pronunciation-scoring based methods. However, current E2E neural methods for CAPT are faced with at least two pivotal challenges.
arxiv
Aggregate, EarlyView.Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai +6 more
wiley +1 more source
Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum [PDF]
Journal of Molecular Neuroscience 27(3): 303-310 (2005), 2007 Prostaglandin E2 (PGE2), is a major prostanoid produced by the activity of cyclooxygenases (COX) in response to various physiological and pathological stimuli. PGE2 exerts its effects by activating four specific E-type prostanoid receptors (EP1, EP2, EP3, and EP4).
arxiv
B(E2) Predictions for Even-Even Nuclei in the Differential Equation Model [PDF]
, 2014 We use the recently developed Differential Equation Model for the reduced electric quadrupole transition probability B(E2) for predicting its values for a wide range of even-even nuclides almost throughout the nuclear landscape from Neon to Californium.
arxiv +1 more source
Prostaglandin E2 induces ovulation in prepubertal mice
Brazilian Journal of Veterinary Research and Animal Science, 2021 The objective of this study was to determine the ability of prostaglandin E2 (PGE2) to induce ovulation and expression of PGE2 receptor (EP2 and EP4) and COX genes (COX-1 and COX-2) in the ovary and pituitary of prepubertal mice.
Jéssica de Souza Andrade +6 more
doaj
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats [PDF]
Journal of Neurochemistry 100(4): 1108-1120 (2007), 2007 Several studies suggest that cyclooxygenase (COX)-2 plays a pivotal role in the progression of ischaemic brain damage. In the present study, we investigated the effects of selective inhibition of COX-2 with nimesulide (12 mg/kg) and selective inhibition of COX-1 with valeryl salicylate (VAS, 12-120 mg/kg) on prostaglandin E2 (PGE2) levels ...
arxiv