Results 111 to 120 of about 9,774,870 (350)

The oestrous cycle of the ewe after active immunization against prostaglandin F-2 alpha.

Journal of Reproduction and Fertility, 1976
Six ewes were immunized against a prostaglandin F-2alpha-protein conjugate. Between 24 and 82 days after immunization the regular cyclic occurrence of oestrus was abolished in all six ewes.
R. Scaramuzzi, D. Baird
semanticscholar   +1 more source

Chemical Proteomics Reveals Human Off‐Targets of Fluoroquinolone Induced Mitochondrial Toxicity

Angewandte Chemie International Edition, EarlyView.
A schematic overview of the adverse effects of Ciprofloxacin related to mitochondrial toxicity. AIFM1 plays a role in the MIA40‐mediated import into the IMS and oxidative folding of nuclear‐encoded proteins, including ETC complexes I and IV subunits. Ciprofloxacin disrupts the IMS import machinery, impairing ETC function.
Till Reinhardt, Yassmine El Harraoui, Alex Rothemann, Adrian T. Jauch, Sigrid Müller‐Deubert, Martin F. Köllen, Timo Risch, Lianne JHC Jacobs, Rolf Müller, Franziska R. Traube, Denitsa Docheva, Stefan Zahler, Jan Riemer, Nina C. Bach, Stephan A. Sieber   +14 more
wiley   +1 more source

Efficacy and safety of travoprost alone or in combination with other agents for glaucoma and ocular hypertension: patient considerations

Clinical Ophthalmology, 2010
Emilio Rintaro Suzuki Jr, Cibele Lima Belico SuzukiInstituto de Olhos Pampulha, Belo, Horizonte, Minas Gerais, BrazilAbstract: Travoprost is a prostaglandin analog used in the management of glaucoma and ocular hypertension for reducing intraocular ...
Emilio Rintaro Suzuki Jr, Cibele Lima Belico Suzuki   +1 more
doaj  

Effect of ultrasonic modification on the protective activity of Flammulina velutipes polysaccharide to prevent ethanol-induced injury on GES-1 cells

Food Science and Human Wellness, 2023
Flammulina velutipes (F. velutipes) polysaccharides were modified by ultrasound at the rated power of 150 W and 900 W. The monosaccharide composition, ultraviolet-visible, and Fourier transform infrared spectral characteristics of F.
Jinrong Xiao, Xin Chen, Jingsi Zhang, Yifan Wang, Lei Zhong, Qiping Zhan, Qiuhui Hu, Liyan Zhao   +7 more
doaj  

Identification of Francisella novicida mutants that fail to induce prostaglandin E2 synthesis by infected macrophages.

Frontiers in Microbiology, 2013
Francisella tularensis is the causative agent of tularemia. We have previously shown that infection with F. tularensis Live Vaccine Strain (LVS) induces macrophages to synthesize prostaglandin E2 (PGE2). Synthesis of PGE2 by F.
Matthew Dale Woolard, Lydia M Barrigan, Lydia M Barrigan, James R Fuller, Adam S Buntzman, Joshua eBryan, Colin eManoil, Tom eKawula, Jeffrey A Frelinger   +8 more
doaj   +1 more source

Identification of structural features in chemicals associated with cancer drug response: A systematic data-driven analysis [PDF]

arXiv, 2013
Motivation: Analysis of relationships of drug structure to biological response is key to understanding off-target and unexpected drug effects, and for developing hypotheses on how to tailor drug thera-pies. New methods are required for integrated analyses of a large number of chemical features of drugs against the corresponding genome-wide responses of
arxiv  

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

Medicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023
Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman, Pablo Duarte, Esteban Dauden, Antonio Cuadrado, María Isabel Rodríguez‐Franco, Manuela G. López, Rafael León   +6 more
wiley   +1 more source

Pseudo-Anosov extensions and degree one maps between hyperbolic surface bundles [PDF]

arXiv, 2005
Let $F',F$ be any two closed orientable surfaces of genus $g'>g\ge 1$, and $f:F\to F$ be any pseudo-Anosov map. Then we can "extend" $f$ to be a pseudo-Anosov map $f':F'\to F'$ so that there is a fiber preserving degree one map $M(F',f')\to M(F,f)$ between the hyperbolic surface bundles.
arxiv  

Metabolomic analysis reveals the molecular mechanism related to leg abnormality in broilers

Animal Research and One Health, EarlyView.
The graphical abstract shows the principal results of this study. Compared to the leg normal broilers, the serum calcium to phosphorus ratio was extremely decreased in the group with deformed leg bones. Additionally, a total of nine differential metabolites significantly associated with leg abnormalities and serum calcium and phosphorus levels were ...
Jumei Zheng, Qi Zhang, Xinxin Tang, Fan Ying, Dawei Liu, Sen Li, Ranran Liu, Jie Wen, QingHe Li, Guiping Zhao   +9 more
wiley   +1 more source

Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES‐1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor

Molecular Informatics, Volume 41, Issue 12, December 2022., 2022
Abstract A deep in silico investigation of various microsomal prostaglandin E2 synthase‐1 (mPGES‐1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active enzyme trimer system (Model A), namely that bound to three glutathione (GSH) cofactor ...
Simone Di Micco, Gianluigi Lauro, Giuseppe Bifulco   +2 more
wiley   +1 more source