Results 21 to 30 of about 9,774,870 (350)

A Potent and Selective Human Prostaglandin F (FP) Receptor Antagonist (BAY-6672) for the Treatment of Idiopathic Pulmonary Fibrosis (IPF).

Journal of Medicinal Chemistry, 2020
Idiopathic pulmonary fibrosis (IPF) is a rare and devastating chronic lung disease of unknown etiology. Despite the approved treatment options nintedanib and pirfenidone, the medical need for a safe and well tolerated anti-fibrotic treatment of IPF ...
H. Beck, Tobias Thaler, D. Meibom, M. Meininghaus, Hannah Joerissen, L. Dietz, Carsten Terjung, Michaela Bairlein, Clemens J von Bühler, S. Anlauf, Chantal Fuerstner, Timo Stellfeld, D. Schneider, K. M. Gericke, Thomas Buyck, Kai Lovis, U. Muenster, Johanna Anlahr, E. Kersten, G. Levilain, Virginia Marossek, R. Kast   +21 more
semanticscholar   +1 more source

Hypothyroidism Affects Uterine Function via the Modulation of Prostaglandin Signaling

Animals, 2021
Thyroid hormones control the functions of almost all body systems. Reproductive dysfunctions, such as abnormal sexual development, infertility, or irregularities in the reproductive cycle, might be associated with thyroid disorders.
Ilona Kowalczyk-Zieba, Joanna Staszkiewicz-Chodor, Dorota Boruszewska, Krzysztof Lukaszuk, Joanna Jaworska, Izabela Woclawek-Potocka   +5 more
doaj   +1 more source

Changes in Hepatic Phospholipid Metabolism in Rats under UV Irradiation and Topically Treated with Cannabidiol

Antioxidants, 2021
The liver is a key metabolic organ that is particularly sensitive to environmental factors, including UV radiation. As UV radiation induces oxidative stress and inflammation, natural compounds are under investigation as one method to counteract these ...
Michał Biernacki, Anna Jastrząb, Elżbieta Skrzydlewska   +2 more
doaj   +1 more source

Inflammatory Markers in Uterine Lavage Fluids of Pregnant, Non-Pregnant, and Intrauterine Device Implanted Mares on Days 10 and 15 Post Ovulation

Animals, 2021
Intrauterine devices (IUDs) are used in mares to suppress oestrous behaviour, but the underlying mechanism is yet to be elucidated. The presence of an embryo or an IUD prevents cyclooxygenase-2 (COX-2) and, subsequently, prostaglandin (PG) release and ...
Maria Montserrat Rivera del Alamo, Tiina Reilas, Karolina Lukasik, Antonio M. Galvão, Marc Yeste, Terttu Katila   +5 more
doaj   +1 more source

Multi‐omics analyses reveal the interaction between colonic microbiota and host in Min and Yorkshire pigs

Animal Research and One Health, EarlyView., 2023
In the present study, we created the weight gain models with Min and Yorkshire pigs and conducted the metagenomics and metabolomics of colon contents and transcriptomics of colon tissue. Further, we revealed the characteristics and functions of the colonic microbiota in Min and Yorkshire pigs and analyzed their interactions with the host. Overall, this
Xiaoyu Huang, Huihui Li, Feng Cheng, Ligang Wang, Guoqing Cao, Lixian Wang, Lijun Shi   +6 more
wiley   +1 more source

Application of N-Dodecyl l-Peptide to Enhance Serum Stability while Maintaining Inhibitory Effects on Myometrial Contractions Ex Vivo

Molecules, 2019
N-Alkylation and N-acylation of the prostaglandin-F2α allosteric modulator l-PDC31 were performed to install various alkyl, PEG and isoprenoid groups onto the l-enantiomer of the peptide.
Julien Poupart, Xin Hou, Sylvain Chemtob, William D. Lubell   +3 more
doaj   +1 more source

A comparative study between prostaglandin F2α and methyl ergometrine in the active management of third stage of labour [PDF]

New Indian Journal of OBGYN, 2018
Objective: The aim of the study is to see the efficacy and safety of intramuscular Prostaglandin F 2α versus intravenous Methyl Ergometrine in active management of third stage labor. Material and Methods: A prospective study was carried out over a period
Sabha Malik, Cimona Lyn Saldanha, Fida Mohammad   +2 more
doaj   +1 more source

Pretreatment of Garlic Oil Extracts Hampers Epithelial Damage in Cell Culture Model of Peptic Ulcer Disease

Medicina, 2022
Background and Objectives: Peptic ulcer disease is a chronic disease affecting up to 10% of the world’s population. Proton pump inhibitors, such as lansoprazole are the gold standard in the treatment of ulcer disease.
Lucija Kuna, Milorad Zjalic, Tomislav Kizivat, Hrvoje Roguljic, Vjera Nincevic, Tea Omanovic Kolaric, Catherine H. Wu, Aleksandar Vcev, Martina Smolic, Robert Smolic   +9 more
doaj   +1 more source

The effect of agility exercise on eicosanoid excretion, oxidant status, and plasma lactate in dogs

BMC Veterinary Research, 2012
Background The objective was to determine the effects of agility exercise on dogs of different skill levels with respect to urinary eicosanoids, urinary 15F2t-isoprostane (lipid peroxidation marker) and hematological/biochemical changes in plasma ...
Baltzer Wendy I, Firshman Anna M, Stang Bernadette, Warnock Jennifer J, Gorman Elena, McKenzie Erica C   +5 more
doaj   +1 more source

Modeling of biological doses and mechanical effects on bone transduction [PDF]

Journal of Theoretical Biology 274, 1 (2011) 36-42, 2011
Shear stress, hormones like parathyroid and mineral elements like calcium mediate the amplitude of stimulus signal which affects the rate of bone remodeling. The current study investigates the theoretical effects of different metabolic doses in stimulus signal level on bone.
arxiv   +1 more source