Results 301 to 310 of about 211,100 (336)

Amide and l-amino derivatives of F prostaglandins as prostaglandin antagonists

Nature, 1978
THE formation in tissues and organs of the different prostaglandins (PGs) is now known to be associated with various pathophysiological situations. There is an urgent need for specific PG antagonists to facilitate experimental differentiation and analysis of the roles of these endogenous PGs.
Y T, Maddox, P W, Ramwell, C S, Shiner, E J, Corey   +3 more
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Prostaglandin F synthase

Prostaglandins & Other Lipid Mediators, 2002
Prostaglandin (PG) F2 is synthesized via three pathways from PGE2, PGD2, or PGH2 by PGE 9-ketoreductase, PGD 11-ketoreductase, or PGH 9-, 11-endoperoxide reductase, respectively. The enzymological and molecular biological properties of these enzymes have been reported in work over the last 30 years.
openaire   +2 more sources

Simple direct radioimmunoassay of the F prostaglandins

Prostaglandins, 1974
Abstract A simplified and accurate method of determining the F prostaglandins in 0.1 ml of serum without previous extraction is described. The procedure involves addition of anti-prostaglandin F2α to serum followed by tritiated prostaglandin, equilibration for 4 hours, removal of unbound prostaglandin with dextran-coated charcoal and subsequent ...
E, Youssefnejadian, E, Walker, I F, Sommerville, I, Craft   +3 more
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Co-localization of prostaglandin F synthase, cyclooxygenase-1 and prostaglandin F receptor in mouse Leydig cells

Histochemistry and Cell Biology, 2007
In order to promote better understanding of the physiological roles of prostaglandin F(2alpha) in the mouse testis, we investigated the protein expression and the cellular localization of the enzymes cyclooxygenase and prostaglandin F synthase that are essential for the production of prostaglandin F(2alpha), and the binding site, which is the ...
Toshiko, Suzuki-Yamamoto, Yukihiko, Sugimoto, Atsushi, Ichikawa, Kazunori, Ishimura   +3 more
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Agents favoring prostaglandin F formation during biosynthesis

Biochemistry, 1975
The microsomal fraction of bovine vesicular gland catalyzed the conversion of eicosapolyenoic acids exclusively to prostaglandin E in the presence of reduced glutathione, while hydrox fatty acids, prostaglandins D and F, decreased to a negligible level.
J A, Chan, M, Nagasawa, C, Takeguchi, C J, Sih   +3 more
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Synthetic Modification of Prostaglandin F2α Indicates Different Structural Determinants for Binding to the Prostaglandin F Receptor Versus the Prostaglandin Transporter

Molecular Pharmacology, 2000
Several principles governing the binding of E series prostaglandins to EP receptors have emerged in recent years. The C-1 carboxyl group binds electrostatically to a conserved arginine residue in the seventh transmembrane segment of the receptor. Prostaglandin E analogs involving bioisosteric replacements of the carboxyl group, such as acylsulfonamide,
V L, Schuster, S, Itoh, S W, Andrews, R M, Burk, J, Chen, K M, Kedzie, D W, Gil, D F, Woodward   +7 more
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ChemInform Abstract: STEREOSELECTIVE REDUCTION OF PROSTAGLANDINS E TO PROSTAGLANDINS F

Chemischer Informationsdienst, 1980
AbstractDie Prostaglandine E (I) gehen bei der Reduktion mit Li in Tetrahydrofuran und flüssigem Ammoniak in die Prostaglandine Fß(II) über.
V. I. MEL'NIKOVA, K. K. PIVNITSKII
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Roles of Prostaglandin F Synthase

2001
Prostaglandin (PG) F2 is widely distributed in various organs, and exhibits various biological actions such as smooth muscle contraction of uterus [1], bronchus [2], and trachea [3], the initiation of parturition [4], and pain transmission [5]. PGF synthase (PGFS) is a dual function enzyme, which catalyzes the reduction of not only PGD2 but also PGH2 ...
Kikuko Watanabe, Toshiko Suzuki-Yamamoto, Mikio Nishizawa, Motonari Fukui, Kazunori Ishimura, Seiji Ito   +5 more
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Conformations of Prostaglandin F _2α and Recognition of Prostaglandins by Their Receptors

Science, 1977
The conformation of prostaglandin F 2α (PGF 2α ) has been determined by x-ray diffraction techniques. Two independent conformers of PGF 2α , studied as the tris(hydroxymethyl)methylamine salt, are observed to adopt the familiar "hairpin" conformation with the α and ω ...
D A, Langs, M, Erman, G T, DeTitta
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Specific reduction of E prostaglandins to F.alpha. prostaglandins and prostaglandin E2 to prostaglandin E1

Journal of the American Chemical Society, 1971
This is an explanation of 2 highly specific reductive processes for the interconversion of primary PGs (prostaglandins). The laboratory procedures are described in detail and the chemical structures of substances involved in the process are diagrammed. A stereospecific reduction of PGE to PGFalpha is described.
E J, Corey, R K, Varma
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