Results 311 to 320 of about 9,718,735 (366)

High‐Dimensional Analysis of Type 2 Lymphocyte Dynamics During Mepolizumab or Dupilumab Treatment in Severe Asthma

Allergy, EarlyView.
We profiled PBMCs in severe asthma patients at baseline and after initiating treatment with mepolizumab or dupilumab. Mepolizumab treatment increases ILC2, Th2, and Tc2 cell frequencies, skewing ILC2 towards CD117low and Th2/Tc2 cells towards a central memory phenotype.
Lorenz Wirth, Whitney Weigel, Christopher T. Stamper, Johan Kolmert, Sabrina de Souza Ferreira, Quirin Hammer, Maria Sparreman Mikus, Jakob Theorell, Lars Andersson I, Ann‐Sofie Lantz, Eva Wallén‐Nielsen, Anne Petrén, Craig E. Wheelock, Apostolos Bossios, Nikolaos Lazarinis, Andrei Malinovschi, Christer Janson, Barbro Dahlén, Thomas Hochdörfer, Christopher Andrew Tibbitt, Sven‐Erik Dahlén, Valentyna Yasinska, Jenny Mjösberg   +22 more
wiley   +1 more source

Urinary prostaglandin metabolites as biomarkers for human labour: Insights into future predictors. [PDF]

PLoS One
Wood EM, Hornaday KK, Newton M, Wang M, Wood SL, Slater DM.   +5 more
europepmc   +1 more source

Potent activity of prostaglandin J₂ on prostanoid DP receptors. [PDF]

J Biol Chem
Senoo K, Fukushima K, Yamamoto H, Hamaguchi A, Suganami A, Takano H, Yamashita M, Regan JW, Tamura Y, Fujino H.   +9 more
europepmc   +1 more source

Is ‘living apart together’ a real advantage for patients consulting for sexual dysfunction? A cohort study

Andrology, EarlyView.
Abstract Background Quantitative research on families has introduced a new category of relationship called living apart together, that is, when a couple in a committed relationship live in separate homes. This study aimed to confirm whether living apart together improves sexual relationships in those suffering from sexual dysfunction.
Clotilde Sparano, Giovanni Corona, Giulia Rastrelli, Linda Vignozzi, Daniele Vignoli, Mario Maggi   +5 more
wiley   +1 more source

Discovery and Functional Validation of EP3 Receptor Ligands with Therapeutic Potential in Cardiovascular Disease. [PDF]

Int J Mol Sci
Alonso-Fernández JR, Montoro-García S, Cruz AF, Ponce-Valencia A, Carmena-Bargueño M, Pérez-Sánchez H.   +5 more
europepmc   +1 more source

Risk of priapism after dynamic penile Doppler ultrasound: Single‐centre experience on a large cohort of patients

Andrology, EarlyView.
Abstract Objectives To evaluate the risk of priapism in patients undergoing Dynamic—Penile duplex ultrasound (D‐PDU) who were referred to our Unit between January 2022 and December 2023. Patients and methods We enrolled 292 patients, of whom 268 underwent Dynamic—Penile duplex ultrasound for erectile dysfunction and 24 for Peyronie's disease.
Giuseppe Grande, Andrea Graziani, Raffaele Scafa, Andrea Delbarba, Nicola Caretta, Pierfrancesco Palego, Alberto Ferlin   +6 more
wiley   +1 more source

Adjuvant‐induced arthritis induces epithelial proliferation and differential expression of SVS2 and SVS3 in the seminal vesicles

Andrology, EarlyView.
Abstract Background Rheumatoid arthritis (RA) is an inflammatory disease triggered by chronic and systemic activation of the immune system, with consequences for male fertility. However, the influence of RA on sexual accessory glands remains poorly investigated.
Thamires Miyako Ito Sigole, Camila Reis Santos, Isabela Fiorentino Souza Nascimento, Erick J. R. Silva, Agnaldo Bruno Chies, Maria Angélica Spadella   +5 more
wiley   +1 more source

Diagnostics of Autoimmune Hepatitis Enabled by Non‐Invasive Clinical Proteomics

Alimentary Pharmacology &Therapeutics, EarlyView.
Mass‐spectrometry‐based proteomic analyses of paired liver‐plasma samples from patients with AIH enabled discovery of numerous proteins showing high diagnostic accuracy. Proteomics may constitute a novel non‐invasive diagnostic tool for AIH if validated in larger, age‐ and sex‐matched cohorts.
Anne‐Sofie Houlberg Jensen, Henriette Ytting, Annelaura Bach Nielsen, Mikkel Parsberg Werge, Elias Badal Rashu, Liv Eline Hetland, Mira Thing, Puria Nabilou, Johan Burisch, Anders Ellekær Junker, Lise Hobolth, Christian Mortensen, Flemming Tofteng, Flemming Bendtsen, Søren Møller, Mogens Vyberg, Reza Rafiolsadat Serizawa, Marie Winther‐Sørensen, Jesper Sloth Kellemann, Lise Lotte Gluud, Nicolai Jacob Wewer Albrechtsen   +20 more
wiley   +1 more source

The thoracic perivascular adipose tissue spontaneously induces vasoconstriction through activation of α1‐adrenoceptors

British Journal of Pharmacology, EarlyView.
Background and Purpose Although perivascular adipose tissue (PVAT) contains substances with contractile properties, its actions on the vascular tone are associated with the release of anticontractile substances. We hypothesize that procontractile PVAT products also exert direct effects on vascular tone. Experimental Approach Thoracic aortas from Wistar
Leonardo Gomes‐Pereira, José Eduardo da Silva‐Santos   +1 more
wiley   +1 more source

GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng, Jasper F. Ooms, Erik H. J. Danen, Laura H. Heitman   +3 more
wiley   +1 more source