Results 141 to 150 of about 113,074 (192)
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Angewandte Chemie International Edition in English, 1975
AbstractThe prostaglandins are lipid‐soluble C20‐carboxylic acids containing a five‐membered ring, several oxygen function, and at least one double bond. They are found in animal organisms where they stimulate, inter alia, the smooth muscle. In the last decade more has been learned about the occurrence, biosynthesis, metabolism and pharmacological ...
B, Samuelsson +4 more
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AbstractThe prostaglandins are lipid‐soluble C20‐carboxylic acids containing a five‐membered ring, several oxygen function, and at least one double bond. They are found in animal organisms where they stimulate, inter alia, the smooth muscle. In the last decade more has been learned about the occurrence, biosynthesis, metabolism and pharmacological ...
B, Samuelsson +4 more
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Prostaglandins and Inflammation
Arteriosclerosis, Thrombosis, and Vascular Biology, 2011 Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain homeostatic functions and mediate pathogenic mechanisms, including the inflammatory response.
Garret Fitzgerald, Emanuela Ricciotti
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Journal of Cardiovascular Pharmacology, 1984
A discussion of important aspects of the effects of prostaglandins on arteries must include (a) the nature of the receptors for the different humoral agents, (b) the potential modulatory role that endogenously produced prostaglandins may play when other vasoactive hormones are present, and (c) the potential for cell-to-cell transfer of substrates for ...
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A discussion of important aspects of the effects of prostaglandins on arteries must include (a) the nature of the receptors for the different humoral agents, (b) the potential modulatory role that endogenously produced prostaglandins may play when other vasoactive hormones are present, and (c) the potential for cell-to-cell transfer of substrates for ...
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Journal of the American Chemical Society, 1971
This is an explanation of 2 highly specific reductive processes for the interconversion of primary PGs (prostaglandins). The laboratory procedures are described in detail and the chemical structures of substances involved in the process are diagrammed. A stereospecific reduction of PGE to PGFalpha is described.
E J, Corey, R K, Varma
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This is an explanation of 2 highly specific reductive processes for the interconversion of primary PGs (prostaglandins). The laboratory procedures are described in detail and the chemical structures of substances involved in the process are diagrammed. A stereospecific reduction of PGE to PGFalpha is described.
E J, Corey, R K, Varma
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JAMA: The Journal of the American Medical Association, 1975
The introduction of dinoprost tromethamine (Prostin F2 Alpha) as an abortifacient in the second trimester of pregnancy represents the first clinical use of a prostaglandin. Various synthetic analogues of the naturally occurring derivatives are being employed investigationally in the treatment of peptic ulcer, hypertension, asthma, and hypercalcemia. In
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The introduction of dinoprost tromethamine (Prostin F2 Alpha) as an abortifacient in the second trimester of pregnancy represents the first clinical use of a prostaglandin. Various synthetic analogues of the naturally occurring derivatives are being employed investigationally in the treatment of peptic ulcer, hypertension, asthma, and hypercalcemia. In
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Cyclosporine and Prostaglandins
Annals of Internal Medicine, 1985Excerpt To the editor: Cyclosporine and its nephrotoxicity have recently been reviewed in your journal (1). Subsequently, Dr.
D, Adu +4 more
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Prostaglandins and Postmaturity
Australian and New Zealand Journal of Obstetrics and Gynaecology, 1977Summary: Levels of E and F prostaglandins in amniotic fluid of patients with prolonged pregnancy have been compared with levels of patients in the last 4 weeks of normal pregnancy. The mean F prostaglandin levels in patients going past term (1,293.3 ± 332.87 pg/ml) were considerably lower than those going into spontaneous labour at term (4,276.71 ± 1 ...
TambyRaja, R.L. +3 more
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Neuroscience Research, 1997
Prostaglandin D2 (PGD2) is the endogenous sleep inducing substance in rats, mice, monkeys and probably in humans. PGD synthase (PGDS), the enzyme that produces PGD2 in the brain, is the key enzyme in sleep regulation. When the enzyme activity is inhibited by its specific inhibitor, SeCl4 in vivo, rats can no longer sleep.
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Prostaglandin D2 (PGD2) is the endogenous sleep inducing substance in rats, mice, monkeys and probably in humans. PGD synthase (PGDS), the enzyme that produces PGD2 in the brain, is the key enzyme in sleep regulation. When the enzyme activity is inhibited by its specific inhibitor, SeCl4 in vivo, rats can no longer sleep.
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