Results 151 to 160 of about 63,897 (315)

NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES

ChemMedChem, Accepted Article.
Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean-François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Investigations into the characterization, degradation, and applications of biodegradable polymers by mass spectrometry

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Biodegradable polymers have been getting more and more attention because of their contribution to the plastic pollution environmental issues and to move towards a circular economy. Nevertheless, biodegradable materials still exhibit various disadvantages restraining a widespread use in the market.
Paola Rizzarelli, Melania Leanza, Marco Rapisarda   +2 more
wiley   +1 more source

Diclofenac Detection via Inner‐Filter Effect Using Pyridine‐Modified Triphenylene

ChemPlusChem, EarlyView.
The synthesis of hexa‐pyridine triphenylene derivatives via Suzuki‐coupling reaction and their application toward the sensing of diclofenac have been studied for the first time. The 3PY and 4PY are selective for diclofenac over the other commonly prescribed pharmaceuticals and hormones tested. Triphenylene derivatives 3PY (2,3,6,7,10,11‐hexa(pyridine‐3‐
Navdeep Kajal, Amar Raj, Rajendhraprasad Tatikonda, Jan Lundell, Matti Haukka   +4 more
wiley   +1 more source

Preservative-free fixed combination of tafluprost 0.0015% and timolol 0.5% in patients with open-angle glaucoma and ocular hypertension: results of an open-label observational study

Clinical Ophthalmology, 2017
Lutz E Pillunat,1 Carl Erb,2 Auli Ropo,3 Friedemann Kimmich,4 Norbert Pfeiffer5 1Department of Ophthalmology, University Hospital Carl Gustav Carus, Dresden, 2Augenklinik am Wittenbergplatz, Berlin, Germany; 3Santen Europe, Helsinki, Finland; 4eyecons ...
Pillunat LE, Erb C, Ropo A, Kimmich F, Pfeiffer N   +4 more
doaj  

Synthesis of 19‐Hydroxyarachidonic Acid by Fungal Peroxygenases: An Experimental and Computational Study

ChemSusChem, EarlyView.
An experimental and computational investigation on the regio‐ and enantioselective hydroxylation of arachidonic acid by several unspecific peroxygenases (UPOs) revealed rAaeUPO A77L variant as the most attractive candidate for the selective production of valuable hydroxy‐fatty acids because of its enhanced regio and enantioselectivity and reduced ...
Alejandro González‐Benjumea, Mireia Martínez‐Sugrañes, Miguel Alcalde, Elvira Romero, Víctor Guallar, Martin Floor, Angel T. Martínez, Ana Gutiérrez   +7 more
wiley   +1 more source

Vasopressin-stimulated prostaglandin E biosynthesis in the toad urinary bladder. Effect of water flow. [PDF]

, 1977
Randall M. Zusman, Harry R. Keiser, Jerome S. Handler   +2 more
openalex   +1 more source

A Telescoped Strategy for the Preparation of Five‐Membered Hetero‐ and Carbocycles via Hydrogen Atom Transfer Photocatalysis in Flow

ChemSusChem, EarlyView.
Pyrroles, thiophenes, and cyclopentenones are vital in drug discovery, yet their synthesis via diversity oriented synthesis is limited. Herein, a modular platform is developed for the scalable, telescoped synthesis of named structures in continuous flow by streamlining photocatalyzed hydrogen atom transfer and Paal–Knorr or Hunsdiecker condensation ...
Filippo Sacchelli, Elena Quadri, Luna Raineri, Alexandra Jorea, Marzia Pessina, Anna Lo Presti, Nicola Della Ca’, Davide Ravelli, Luca Capaldo   +8 more
wiley   +1 more source

The Effect of Chronic Sodium Loading and Sodium Restriction on Plasma Prostaglandin A, E and F Concentrations in Normal Humans [PDF]

, 1973
Randall M. Zusman, David A. Spector, Burton V. Caldwell, Leon Speroff, George Schneider, Patrick J. Mulrow   +5 more
openalex   +1 more source

Bioinformatics analysis of immune‐programmed cell death‐related genes in nasopharyngeal carcinoma

Eye &ENT Research, EarlyView.
Abstract Background Nasopharyngeal carcinoma (NPC) is a prevalent malignant tumor of the head and neck, characterized by a complex pathogenesis. Most newly diagnosed NPC patients are locally advanced, and 20%–30% of advanced NPC patients have poor immunotherapy results.
Hongqiang Chen, Zhe Zhang, Xueting Yang, Chao Li   +3 more
wiley   +1 more source