Results 161 to 170 of about 19,015,309 (380)
Abstract Biodegradable polymers have been getting more and more attention because of their contribution to the plastic pollution environmental issues and to move towards a circular economy. Nevertheless, biodegradable materials still exhibit various disadvantages restraining a widespread use in the market.
Paola Rizzarelli+2 more
wiley +1 more source
Prostaglandin E 1 Effects on Adenosine 3′:5′-Cyclic Monophosphate Concentration and Phosphodiesterase Activity in Fibroblasts [PDF]
Vincent Maganiello, Martha Vaughan
openalex +1 more source
By N‐methylation, the intramolecular lactam formation in carborane‐substituted diclofenac analogs is prevented, yielding a series of open‐chain derivatives alongside with their phenyl analogs exhibiting anticancer activity and thus offering a promising avenue for future drug development. This study explores the anticancer potential of N‐methylated open‐
Christoph Selg+12 more
wiley +1 more source
The cylcooxygenase isoforms COX‐1 and COX‐2 are involved in the production of prostaglandins in physiological and pathological processes. The overexpression of COX‐2 under inflammatory conditions as well as its role in cancer and neurodegenerative diseases necessitates the need to develop and improve non‐steroidal anti‐inflammatory drugs.
Lea Ueberham+8 more
wiley +1 more source
Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman+6 more
wiley +1 more source
Abstract A deep in silico investigation of various microsomal prostaglandin E2 synthase‐1 (mPGES‐1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active enzyme trimer system (Model A), namely that bound to three glutathione (GSH) cofactor ...
Simone Di Micco+2 more
wiley +1 more source
The effects of prostaglandins E1, F1α and F2α on monosynaptic reflexes
P Duda, E. W. HORTON, Angus McPherson
openalex +2 more sources
Edge mappings of graphs: Turán type parameters [PDF]
In this paper, we address problems related to parameters concerning edge mappings of graphs. The quantity $h(n,G)$ is defined to be the maximum number of edges in an $n$-vertex graph $H$ such that there exists a mapping $f: E(H)\rightarrow E(H)$ with $f(e)\neq e$ for all $e\in E$ and further in all copies $G'$ of $G$ in $H$ there exists $e\in E(G ...
arxiv
Abstract This small phase 1C, open‐label, single ascending dose study evaluated the safety, tolerability, and pharmacokinetics (PKs) of DM199, a recombinant form of human tissue kallikrein‐1 (KLK1). A small sample size of both healthy subjects and hypertensive adults recently taking angiotensin‐converting enzyme inhibitors was studied. KLK1 has a known
Michael Giuffre+3 more
wiley +1 more source
Inflammatory responses are thought to be mediated in part by the prostaglandins derived from arachidonic acid (AA) by the action of prostaglandin H synthase, also referred to as cyclooxygenase (COX).
Regina E. Maldve+3 more
doaj