Results 91 to 100 of about 52,245 (306)

Effect of Methotrexate and Omega-3 Combination on Cytogenetic Changes of Bone Marrow and Some Enzymatic Antioxidants: An Experimental Study

open access: yesYemeni Journal for Medical Sciences, 2017
Introduction Methods Resuts Discussion Conclusions Acknowledgments Authors' contributions Competing interests Ethical approval References Effect of Methotrexate and Omega-3 Combination on Cytogenetic Changes of Bone Marrow and Some ...
Inaam N. Ali   +2 more
doaj   +3 more sources

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

open access: yesAdvanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng   +19 more
wiley   +1 more source

Stimulating actions of various prostaglandins and noradrenaline in strips of rabbit renal artery [PDF]

open access: yes, 1978
The myotropic effects of prostaglandins E1, E2, F2α, A1, and noradrenaline were evaluated in spirally cut strips of rabbit renal arteries suspended in a physiological salt solution maintained at 37 °C.
F. Rioux, D. Regoli, G. Gagnon
core   +1 more source

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

open access: yesAdvanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao   +11 more
wiley   +1 more source

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

open access: yesAdvanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa   +5 more
wiley   +1 more source

Prostaglandins may mediate the stimulation of neonatal rat hepatocytes DNA synthesis by tumor promoters [PDF]

open access: yes, 1983
Prostaglandins may mediate the stimulation of neonatal rat hepatocytes DNA synthesis by tumor ...
F. ROMANO, P. G. ANDREIS, ARMATO, Ubaldo
core  

Pulmonary vascular response to high-frequency oscillatory ventilation in dogs: lack of effect of indomethacin [PDF]

open access: yes
The role of prostaglandins (PG) in the pulmonary hypertension associated with high-frequency oscillatory ventilation (HFOV) was investigated in 7 pentobarbital-anesthetized dogs.

core   +1 more source

Vasodilation of cat cerebral arterioles by prostaglandins D2, E2, G2, and I2 [PDF]

open access: yes, 1979
To determine the possible role that endogenously produced prostaglandins may play in the regulation of cerebral blood flow, the responses of cerebral precapillary vessels to prostaglandins (PG) D2, E2, G2, and I2 (8.1 X 10(-8) to 2.7 X 10(-5) M) were ...
E. F. Ellis, H. A. Kontos, E. P. Wei
core   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

open access: yesAdvanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori   +10 more
wiley   +1 more source

Vitamin-protein product based on selected strains of fungi: characteristic and application

open access: yesФактори експериментальної еволюції організмів, 2013
Aim. Morphological, physiological and biochemical properties of select strain mycelial fungi-producing protein, vitamins, co-enzymes were studied. Results.It was established that strains of Fusarium sambucinum F-10011F F-139 have a high growth rate of 0,
S. M. Suprun   +7 more
doaj  

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