Results 261 to 270 of about 9,538,896 (341)

Amide and l-amino derivatives of F prostaglandins as prostaglandin antagonists

Nature, 1978
THE formation in tissues and organs of the different prostaglandins (PGs) is now known to be associated with various pathophysiological situations. There is an urgent need for specific PG antagonists to facilitate experimental differentiation and analysis of the roles of these endogenous PGs.
Y T, Maddox, P W, Ramwell, C S, Shiner, E J, Corey   +3 more
openaire   +2 more sources

Conformations of Prostaglandin F _2α and Recognition of Prostaglandins by Their Receptors

Science, 1977
The conformation of prostaglandin F 2α (PGF 2α ) has been determined by x-ray diffraction techniques. Two independent conformers of PGF 2α , studied as the tris(hydroxymethyl)methylamine salt, are observed to adopt the familiar "hairpin" conformation with the α and ω ...
D A, Langs, M, Erman, G T, DeTitta
openaire   +2 more sources

Simple direct radioimmunoassay of the F prostaglandins

Prostaglandins, 1974
Abstract A simplified and accurate method of determining the F prostaglandins in 0.1 ml of serum without previous extraction is described. The procedure involves addition of anti-prostaglandin F2α to serum followed by tritiated prostaglandin, equilibration for 4 hours, removal of unbound prostaglandin with dextran-coated charcoal and subsequent ...
E, Youssefnejadian, E, Walker, I F, Sommerville, I, Craft   +3 more
openaire   +2 more sources

Intramyometrial prostaglandin F2α

American Journal of Obstetrics and Gynecology, 1972
Abstract Hypertonic saline and prostaglandin F 2α were injected into pregnant monkey myometrium. Small volumes of 20 per cent saline produced full-thickness myometrial necrosis with hemorrhage and thrombosis. PGF 2α in amounts sufficient to induce uterine contractions caused no histologic change.
A C, Wentz, T M, King
openaire   +2 more sources

synthesis of progesterone and prostaglandin F by luteal tissue and prostaglandin F by endometrial tissue from the pig

Prostaglandins, 1978
Abstract The relationship between progesterone (P 4 ) synthesis in vitro by luteal tissue and prostaglandin F (PGF) synthesis in vitro by endometrium and luteal tissue from two stages of the cycle, Days 7 to 8 and 15 to 16, was determined.
H D, Guthrie, C E, Rexroad, D J, Bolt
openaire   +2 more sources

Prostaglandin F synthase

Prostaglandins & Other Lipid Mediators, 2002
Prostaglandin (PG) F2 is synthesized via three pathways from PGE2, PGD2, or PGH2 by PGE 9-ketoreductase, PGD 11-ketoreductase, or PGH 9-, 11-endoperoxide reductase, respectively. The enzymological and molecular biological properties of these enzymes have been reported in work over the last 30 years.
openaire   +2 more sources

Synthetic Modification of Prostaglandin F2α Indicates Different Structural Determinants for Binding to the Prostaglandin F Receptor Versus the Prostaglandin Transporter

Molecular Pharmacology, 2000
Several principles governing the binding of E series prostaglandins to EP receptors have emerged in recent years. The C-1 carboxyl group binds electrostatically to a conserved arginine residue in the seventh transmembrane segment of the receptor. Prostaglandin E analogs involving bioisosteric replacements of the carboxyl group, such as acylsulfonamide,
V L, Schuster, S, Itoh, S W, Andrews, R M, Burk, J, Chen, K M, Kedzie, D W, Gil, D F, Woodward   +7 more
openaire   +2 more sources

Utilization of a single antiserum for the direct radioimmunoassay of prostaglandins E and F in semen and prostaglandin F in amniotic fluid

Prostaglandins, 1974
Abstract Antibodies to both prostaglandin F (PGF) and prostaglandin E (PGE) were raised in rabbits after they were immunized with prostaglandin F2a conjugated to bovine serum albumin (PGF2a - BSA). The antisera were group specific although the antibodies to the F group of prostaglandins showed greater specificity than those to the E group.
A H, Clarke, R M, Ing, W R, Jones, D, Llewellyn-Jones, D A, Shutt   +4 more
openaire   +2 more sources

Co-localization of prostaglandin F synthase, cyclooxygenase-1 and prostaglandin F receptor in mouse Leydig cells

Histochemistry and Cell Biology, 2007
In order to promote better understanding of the physiological roles of prostaglandin F(2alpha) in the mouse testis, we investigated the protein expression and the cellular localization of the enzymes cyclooxygenase and prostaglandin F synthase that are essential for the production of prostaglandin F(2alpha), and the binding site, which is the ...
Toshiko, Suzuki-Yamamoto, Yukihiko, Sugimoto, Atsushi, Ichikawa, Kazunori, Ishimura   +3 more
openaire   +2 more sources

Prostaglandin F2α Receptor-Dependent Regulation of Prostaglandin Transport

Molecular Pharmacology, 2001
Prostaglandin (PG) F(2alpha) may act on its G protein-coupled receptor (FP) or be imported intracellularly via a transporter, which has high affinity for PGF(2alpha) and PGE(2), but not prostacyclin (PGI(2)). In cells overexpressing the epitope-tagged FP together with the human prostaglandin transporter (hPGT), stimulation of the FP with PGF(2alpha) (1
R, Vezza, J, Rokach, G A, FitzGerald
openaire   +2 more sources