Results 151 to 160 of about 233,415 (250)

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Prostate cancer risk-associated single-nucleotide polymorphisms impact the conformational dynamics of prostate-specific antigen. [PDF]

BMC Biol
Srinivasan S, Hayes BK, Costa MGS, Riley BT, Wilson E, Marijanovic EM, Kass I, Koistinen H, Hoke DE, Clements J, Buckle AM, Batra J.   +11 more
europepmc   +1 more source

Polygenic risk score and prostate specific antigen predict death from prostate cancer in men with intermediate aggressive cancer

International Journal of Cancer, EarlyView.
What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago, Efthymios Ladoukakis, Dorota Scibior‐Bentkowska, Belinda Nedjai   +3 more
wiley   +1 more source

The predictive value of multiparametric magnetic resonance imaging in enhancing prostate-specific antigen assessment for prostate cancer: a cross-sectional study. [PDF]

Transl Androl Urol
Yu H, Wu J, Yang S.
europepmc   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Utility of prostate-specific antigen derivatives to minimize unnecessary magnetic resonance imaging in patients with prior negative prostate biopsy. [PDF]

Sci Rep
Lee S, Ryu H, Song SH, Hwang SI, Lee HJ, Lee H, Hong SK, Byun SS, Song B.   +8 more
europepmc   +1 more source

Comparing the effectiveness of prostate cancer screening protocols: European Association of Urology– and European Randomized Study of Screening for Prostate Cancer–based strategies

International Journal of Cancer, EarlyView.
What's New? Although screening reduces prostate cancer mortality, concerns about overdiagnosis and unnecessary biopsies have given rise to more tailored strategies. The European Association of Urology (EAU) proposed a risk‐adapted screening strategy combining prostate‐specific antigen (PSA)‐based intervals, a risk calculator, and magnetic resonance ...
Zhenwei Yang, Luuk A. van Duuren, Monique J. Roobol, Nicole S. Erler, Dimitris Rizopoulos, Eveline A. M. Heijnsdijk   +5 more
wiley   +1 more source

Association of Socioeconomic Position, Prostate-specific Antigen, and Age with Observation in Low-risk Prostate Cancer Patients in Switzerland. [PDF]

Eur Urol Open Sci
Scherer TP, Menges D, Bieri U, Wildisen L, Staehelin K, Schmid FA, Kaufmann B, Eberli D, Rohrmann S, Poyet C.   +9 more
europepmc   +1 more source

Tumor‐educated platelets in cancer diagnostics and prognostics: A critical appraisal and roadmap for clinical translation

International Journal of Cancer, EarlyView.
Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon, Min‐Kyung Lee, Eunyong Ahn, Heeyeon Kim, Yong Sang Song, Taejin Ahn   +5 more
wiley   +1 more source

Diagnostic accuracy of PSA derivatives for prostate cancer in patients with low prostate-specific antigen levels. [PDF]

Front Oncol
Kadeer A, Maolake A, Aimaier A, Abuduwaili M, Ni Z, Li J.   +5 more
europepmc   +1 more source