Results 181 to 190 of about 670,718 (407)

Rare event simulation in immune biology: Models of negative selection in T-cell maturation [PDF]

arXiv, 2014
We present a probabilistic T-cell model that includes negative selection and takes contrasting models of tissue-restricted antigen (TRA) expression in the thymus into account. We start from the basic model of van den Berg, Rand, and Burroughs (2001) and include negative selection via individual-based T-cell modelling, in which each T-cell is defined by
arxiv  

Longitudinal evaluation of prostate-specific antigen levels in men with and without prostate disease [PDF]

, 1992
H. B. Carter
openalex   +1 more source

Microneedles at the Forefront of Next Generation Theranostics

Advanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang, Yuan Yang, Jiaqi Zhang, Hanrui Zhang, Qian Wang, Shengmei Ma, Pengfei Zhao, Zhou Li, Yuxin Liu   +8 more
wiley   +1 more source

Purification and Characterization of the Prostate Cancer-Associated Antigen: 7E11-C5 [PDF]

, 1991
A murine monoclonal antibody (MAb), 7E11-C5, recognizes a prostate organ-specific antigen. Under reducing conditions, the 7E11-C5 antigen exhibited major 100-Kd and minor 70-Kd bands, suggesting that the antigen comprises two peptide chains.
Feng, Qi
core   +1 more source

Prostate‐specific antigen lewels in 1695 men without evidence of prostate cancer: Findings of the American cancer society national prostate cancer detection project [PDF]

, 1992
Robert A. Kane, Peter J. Littrup, Richard J. Babaian, J R Drago, Fred Lee, Arthur Chesley, Gerald P. Murphy, Curtis Mettlin   +7 more
openalex   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

Recovery of ζ-chain expression and changes in spontaneous IL-10 production after PSA-based vaccines in patients with prostate cancer [PDF]

Circulating T lymphocytes of patients with prostate cancer have been reported to have functional deficits, including low or absent ζ-chain expression. To determine whether these functional impairments could be reversed by prostate specific antigen-based ...
AH Zea, AM Deakin, BR Gastman, C Maccalli, CG Healy, CR Alving, D Harris, DD Taylor, E Tartour, F De Vita, G Cardi, G Dworacki, GP Murphy, H Rabinowich, H Rabinowich, I Kuss, J Schmielau, JJ Lewis, JW Gratama, K Kono, K Kono, KW Moore, L Spitler, M Matsuda, N Meidenbauer, N Meidenbauer, NM Wassef, PA Lodge, RM Bukowski, S Horiguchi, T Asai, T L Whiteside, TE Reichert, TL Whiteside, W Gooding, Åke Lundwall   +35 more
core   +2 more sources

Standardization of immunoassays for prostate-specific antigen. A problem of prostate-specific antigen complexation or a problem of assay design? [PDF]

, 1993
Howard C.B. Graves
openalex   +1 more source

Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions

Advanced Science, EarlyView.
Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He, Siliang Chen, Xiaoyun Wang, Xiang Wen, Changyang Gong, Lei Liu, Gu He   +6 more
wiley   +1 more source

Treatment‐related adverse events of antibody–drug conjugates in clinical trials: A systematic review and meta‐analysis

Cancer, Volume 129, Issue 2, Page 283-295, 15 January 2023., 2023
Abstract Background Antibody–drug conjugates (ADCs) have complex molecular structures and have been tested in numerous clinical trials. Therefore, understanding the mechanisms of their toxicity when applied in medical practice is of high importance. Methods In a systematic review and meta‐analysis of data gathered from different scientific databases ...
Youwen Zhu, Kun Liu, Kailing Wang, Hong Zhu   +3 more
wiley   +1 more source