Results 281 to 290 of about 366,020 (324)

Tumor Organoids: Breakthroughs in Clinical Decision Making, Drug Development, and Translational Advances Beyond Conventional Models

Med Research, EarlyView.
ABSTRACT Tumor organoid models are revolutionizing cancer research by bridging the translational gap between conventional two‐dimensional cell cultures and animal models. This Editorial thoroughly explores the fundamental innovations of patient‐derived organoid technology.
Yimao Wu, Ruowei Sun, Gokhan Zengin, Shuai Ren, Meng‐Yao Li   +4 more
wiley   +1 more source

Association of Prostate Imaging Reporting and Data System (PI-RADS) Score and Prostate-Specific Antigen Density (PSAD) With Prostate Biopsy Histology Outcomes: A Retrospective Study. [PDF]

Cureus
Balasubaramaniam V, Agarwal A, Kailasa A, Ismail NAB, Grogan D, Shoker A, Rhodes KV, Donev K, Kannan S.   +8 more
europepmc   +1 more source

Determination of Critical Organ Doses with 177Lu Prostate-specific Membrane Antigen Dosimetry in Metastatic Prostate Cancer Treatment

G Yilidir, Mustafa Demır
openalex   +1 more source

Advances and Prospects of Stereotactic Radiosurgery and Stereotactic Ablative Body Radiotherapy: Evolving Paradigms in Precision Oncology

Med Research, EarlyView.
The graphical abstract outlines the progressive development and impact of stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). Technological Evolution illustrates the transition from brachytherapy with single‐dose, LDR/HDR schedules to fractionated radiotherapy, three‐dimensional conformal radiotherapy (3DCRT) and Gamma Knife ...
Jing Zhang, Wenhao Xu, Weiqing Lu, Yingxuan Lin, Luoxi He, Zonglin Lv, Yiliyaer Nuerrula, Zouting, Zhen Zhang, Hailiang Zhang, Xuejun Ma   +10 more
wiley   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Is there a relationship between serum uric acid and prostate-specific antigen in middle-aged and elderly Chinese men? [PDF]

Eur J Med Res
Wang Y, Zhan X, Ma C, Zhai X, Chu C, Ju G, Tan M, Gu J, Guo D, Xu D.   +9 more
europepmc   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Clinical Relevance of Digital Rectal Examination in Men With Low and Very Low Prostate-Specific Antigen (PSA): Reassessing Its Diagnostic Value in the MRI Era and in Light of Modern Guidelines. [PDF]

Cureus
Franz T, Stolzenburg JU.
europepmc   +1 more source

Strong‐Gradient Diffusion‐Weighted Imaging of Prostate Cancer Using an Inside‐Out Nonlinear Gradient Coil

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To demonstrate improved image quality and lesion conspicuity in prostate diffusion‐weighted imaging (DWI) using an inside‐out nonlinear gradient coil that provides locally strong gradients (200–500 500 mT/m) at typical prostate positions.
Horace Z. Zhang, Nahla M. H. Elsaid, Terence W. Nixon, Andrew Dewdney, Dana C. Peters, Jeffrey C. Weinreb, Preston C. Sprenkle, R. Todd Constable, Gigi Galiana   +8 more
wiley   +1 more source

Biparametric MRI-based radiomics for differentiating clinically significant prostate cancer among prostate-specific antigen level of gray zone. [PDF]

Front Oncol
Ji Y, Liu W, Liu H, Wen J.
europepmc   +1 more source