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Seminars in Cancer Biology, 1999
Prostate specific antigen (PSA) is serine protease produced at high concentrations by normal and malignant prostatic epithelium. It is mainly secreted into seminal fluid, where it digests the gel forming after ejaculation. Only minor amounts of PSA leak out into circulation from the normal prostate, but the release of PSA is increased in prostatic ...
U H, Stenman +3 more
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Prostate specific antigen (PSA) is serine protease produced at high concentrations by normal and malignant prostatic epithelium. It is mainly secreted into seminal fluid, where it digests the gel forming after ejaculation. Only minor amounts of PSA leak out into circulation from the normal prostate, but the release of PSA is increased in prostatic ...
U H, Stenman +3 more
openaire +2 more sources
PROSTATE-SPECIFIC ANTIGEN DENSITY
Urologic Clinics of North America, 1997Nearly 20 years have passed since PSA was definitively identified. Throughout this period, its clinical application as a tumor marker has expanded significantly. Today, besides monitoring prostate cancer therapy, PSA is being used extensively in mass screening programs for early detection of adenocarcinoma of the prostate and has become the most ...
M C, Beduschi, J E, Oesterling
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Prostate-specific membrane antigen
The Prostate, 1997In an effort to discover new prostate-specific antigens (PSAs) to enhance our understanding of the functions and behavior of the prostate and the complex processes involved in prostate tumor progression, the structure and function of the PSM antigen has been elucidated.The PSM antigen was recognized using the 7E11-C5.3 monoclonal antibody, generated ...
W R, Fair, R S, Israeli, W D, Heston
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New England Journal of Medicine, 1987
After half a century of clinical application, the usefulness of prostatic acid phosphatase (PAP) as a marker for carcinoma of the prostate is being challenged. Historically the first of the "serum markers" for the presence of a human cancer,1 acid phosphatase is still measured in clinical laboratories all over the world.
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After half a century of clinical application, the usefulness of prostatic acid phosphatase (PAP) as a marker for carcinoma of the prostate is being challenged. Historically the first of the "serum markers" for the presence of a human cancer,1 acid phosphatase is still measured in clinical laboratories all over the world.
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Deutsche medizinische Wochenschrift (1946), 1995
Prostate specific antigen (PSA) is a 34 000 Da molecular weight glycoprotein found exclusively in the prostate, prostatic fluid and seminal plasma.
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Prostate specific antigen (PSA) is a 34 000 Da molecular weight glycoprotein found exclusively in the prostate, prostatic fluid and seminal plasma.
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1994
PSA is a 34-kDa 240-amino-acid glycoprotein produced exclusively by prostatic epithelial cells. PSA is a serine protease, is a member of the kallikrein gene family, and has a high sequence homology with human glandular kallikrein. It has chymotrypsin-, trypsin-, and esterase-like activities.
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PSA is a 34-kDa 240-amino-acid glycoprotein produced exclusively by prostatic epithelial cells. PSA is a serine protease, is a member of the kallikrein gene family, and has a high sequence homology with human glandular kallikrein. It has chymotrypsin-, trypsin-, and esterase-like activities.
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