Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Journal of Urological Surgery, 2016 Objective To determine the possible effect of climate parameters on prostate specific anigen (PSA) levels. Materials and Methods Among 2.150 males, 757 individuals participating in a general check-up service at our hospital group in the past one year ...
Murat Tuğrul Eren +2 more
doaj +1 more source
The diagnostic accuracy and cost-effectiveness of magnetic resonance spectroscopy and enhanced magnetic resonance imaging techniques in aiding the localisation of prostate abnormalities for biopsy : a systematic review and economic evaluation [PDF]
, 2013 Peer reviewedPublisher ...
Boachie, C +11 more
core +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Negative multiparametric magnetic resonance imaging for prostate cancer: what's next? [PDF]
, 2018 Multiparametric magnetic resonance imaging (mpMRI) of the prostate has excellent sensitivity in detecting clinically significant prostate cancer (csPCa).
Barchetti, Flavio +12 more
core +1 more source
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Role of miRNA Let-7 and Its Major Targets in Prostate Cancer [PDF]
, 2014 Prostate cancer is worldwide the sixth leading cause of cancer related death in men thus early detection and successful treatment are still of major interest.
Murua Escobar, Hugo +3 more
core +7 more sources
Prostate-specific antigen screening: pro [PDF]
Current Opinion in Urology, 2010 Prostate cancer is the most common noncutaneous malignancy among men in the USA and is most frequently diagnosed through prostate-specific antigen (PSA)-based screening. Nevertheless, PSA testing has become increasingly controversial. In this review, we will present the evidence supporting the role of PSA in prostate cancer screening.Numerous studies ...
Stacy, Loeb, William J, Catalona
openaire +2 more sources
Impact of Individual Risk Assessment on Prostate Cancer Diagnosis [PDF]
, 2012 Current prostate-specific antigen screening practice leads to two important unwanted side effects; first of all screening induces many unnecessary prostate biopsies and secondly it leads to overdiagnosis and overtreatment of prostate cancer.
Vugt, H.A. (Heidi) van
core
Oncologic Outcomes of Radical Prostatectomy and Prognostic Stratification in Patients with Clinically Locally Advanced Prostate Cancer [PDF]
, 2017 Oncologic outcomes of radical prostatectomy in 106 patients with clinically locally advanced prostate cancer were demonstrated. The mean follow-up was 50.6 (12-129) months.
Banas, O. (Oleksandr) +6 more
core +2 more sources