Results 61 to 70 of about 120,528 (253)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

68Ga–Prostate-Specific Membrane Antigen Uptake in a Malignant Pleural Effusion From Metastatic Prostate Cancer After Pleurodesis [PDF]

, 2019
A 76-year-old man with metastatic adenocarcinoma of the prostate presented with increasing dyspnea. After being treated initially with drainage and afterwards with pleurodesis, he was referred for Ga-prostate-specific membrane antigen 11 PET/CT imaging ...
Afshar Oromieh, Ali, Sachpekidis, Christos, Alberts, Ian Leigh, Rominger, Axel Oliver   +3 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Moving ahead of prostate-specific antigen

Medical Journal of Dr. D.Y. Patil University, 2016
Prostate gland is the second most leading site of cancer among males in Indian cities and it is the second most common site of cancer among US men. Prostate cancer (PCa) is the sixth leading cause of cancer death among men worldwide.
Banyameen Mohamad Iqbal, Mushtaq Ahmed Peer   +1 more
doaj   +1 more source

Association between Prostinogen (KLK15) genetic variants and prostate cancer risk and aggressiveness in Australia and a meta-analysis of GWAS data [PDF]

, 2011
Background Kallikrein 15 (KLK15)/Prostinogen is a plausible candidate for prostate cancer susceptibility. Elevated KLK15 expression has been reported in prostate cancer and it has been described as an unfavorable prognostic marker for the disease ...
Artitaya Lophatananon, Judith A Clements, Lophatananon, A, Rahman, Aneela, Marquart, Louise, Joanne Aitken, Kenneth Muir, Kedda, M A, Alexander, K, Gardiner, Robert A., Carson Stephens, Easton, Douglas F, Al Olama, AA, Muir, Ken, Jenny L Donovan, Rahman, A A, Muir, K, Rosalind A Eeles, Hamdy, Freddie C., Olama Ali Amin Al, Aneela A. Rahman, Guy, Michelle, Kedda Mary-Anne, Srinivasan Srilakshmi, Donovan, Jenny L., Stephens, C, Aitken, Joanne, Yaxley, John, Clements, Judith A., Donovan, Jenny L, Hamdy, Freddie C, Al Olama, A A, Srinivasan, S, O'Mara, T, Hamdy, FC, Donovan, JL, Guy Michelle, Louise Marquart, Rahman, AA, Lose Felicity, Kedda, MA, Suzanne Chambers, David E. Neal, A. Rahman, Aneela, F. Easton, Douglas, Lophatananon Artitaya, Chambers Suzanne, Gardiner, R A, A. Clements, Judith, C. Hamdy, Freddie, Batra, J, Easton Douglas F., Neal David E., Clements Judith A., Spurdle, Amanda B., A. Eeles, Rosalind, Spurdle, AB, Neal, David E, Neal, David, Eeles, Rosalind A, Easton, DF, L. Donovan, Jenny, Douglas F. Easton, Stephens Carson, Spurdle, A. B., Easton, D F, A. Gardiner, Robert, Donovan, Jenny, Rosalind A. Eeles, Gardiner, Robert, Clements, J. A., Kote-Jarai, Zsofia, Eeles, Rosalind, Easton, Douglas, Gardiner Robert A., Aitken Joanne, Srilakshmi Srinivasan, Rahman, Aneela A., Neal, David E., Freddie C. Hamdy, Kote-Jarai, Z, Freddie C Hamdy, B. Spurdle, Amanda, Ali Amin Al Olama, Yaxley, J, Rahman Aneela A., Guy, M, Easton, Douglas F., O'Mara, Tracy, Alexander, Kimberly, Spurdle, Amanda B, Chambers, Suzanne, Felicity Lose, Gardiner, Robert A, Donovan, J L, Alexander, Kimberley, Clements, Judith A, Robert A. Gardiner, David E Neal, Judith A. Clements, Clements, JA, Muir Kenneth, Kedda, Mary-Anne, Clements, J A, Gardiner, RA, Clements, Judith, Marquart Louise, Batra, Jyotsna, Al Olama, Ali Amin, Lose, F, Eeles, R A, Srinivasan, Srilakshmi, Neal, D E, Marquart, L, Amanda B Spurdle, Mary-Anne Kedda, Donovan Jenny L., Muir, Kenneth, Aitken, J, Neal, DE, Batra Jyotsna, Lophatananon, Aritaya, Rahman, Aneela A, Robert A Gardiner, Spurdle, A B, Eeles, RA, John Yaxley, O'Mara Tracy, Douglas F Easton, Hamdy, F C, Stephens, Carson, Tracy O'Mara, Michelle Guy, Zsofia Kote-Jarai, Hamdy, Freddie, Spurdle, Amanda, Eeles Rosalind A., Yaxley John, Kote-Jarai Zsofia, Kimberly Alexander, Alexander Kimberly, Aneela A Rahman, Hamdy Freddie C., Spurdle Amanda B., Jenny L. Donovan, E. Neal, David, Amanda B. Spurdle, Lose, Felicity, Jyotsna Batra, Olama, Ali Amin Al, Chambers, S, Eeles, Rosalind A., Lophatananon, Artitaya   +152 more
core   +1 more source

Prostate-specific Membrane Antigen Positron Emission Tomography in the Staging of Newly Diagnosed Prostate Cancer: Is More Sensitivity Always Better? [PDF]

, 2023
Higher diagnostic accuracy, even if desirable, is not automatically associated with better outcomes. If used in settings validated with less sensitive imaging modalities, it is of paramount importance to prospectively ascertain that the higher ...
Abirramy Varatharajan, Vinay Prasad, Varatharajan, Abirramy, Timothée Olivier, Prasad, Vinay, Olivier, Timothée   +5 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Effect of Temperature and Humidity on Serum Prostate Specific Antigen Levels in Asymptomatic Male Population

Journal of Urological Surgery, 2016
Objective To determine the possible effect of climate parameters on prostate specific anigen (PSA) levels. Materials and Methods Among 2.150 males, 757 individuals participating in a general check-up service at our hospital group in the past one year ...
Murat Tuğrul Eren, Hakan Özveri, Erdal Coşgun   +2 more
doaj   +1 more source

Relationship of Prostate-Specific Antigen (PSA) and Prostate Volume in Patients with Biopsy Proven Benign Prostatic Hyperplasia (BPH)

Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya, 2020
Benign prostatic hyperplasia (BPH) is one of the most common benign tumors in men with prevalence ranging from 50% for men in their 60s to 90% for men in their 80s.
Aulia Nur Fadila, Anny Setijo Rahaju, Tarmono Tarmono   +2 more
doaj   +1 more source

Negative Biopsies with Rising Prostate-Specific Antigen. What To Do? [PDF]

, 2017
Introduction: Prostate-specific antigen (PSA) is the main tool of detection for prostate cancer (PCa). However, PSA has limited specificity and sensitivity in determining the presence of PCa, leading to unnecessary biopsies and the diagnosis of ...
Mario Alvarez-Maestro, Moises Rodriguez Socarras, Stacy Loeb, Stefan Czarniecki, Juan Gómez Rivas, Marcin Czarniecki   +5 more
core