Results 11 to 20 of about 205,631 (301)

PSMA targeting in metastatic castration-resistant prostate cancer: where are we and where are we going?

Therapeutic Advances in Medical Oncology, 2021
Prostate-specific membrane antigen (PSMA) is highly expressed on the membrane of most prostate cancer cells and to a lesser extent in normal tissues. Many vectors targeting this protein have been created over the past decade and numerous clinical studies
Anne-Laure Giraudet, David Kryza, Michael Hofman, Aurélie Moreau, Karim Fizazi, Aude Flechon, Rodney J. Hicks, Ben Tran   +7 more
doaj   +1 more source

A prospective phase II study of prostate-specific antigen-guided salvage radiotherapy and 68Ga-PSMA-PET for biochemical relapse after radical prostatectomy – The PROPER 1 trial

Clinical and Translational Radiation Oncology, 2022
Background and purpose: The treatment of biochemical recurrence (BCR) after prostatectomy is challenging as the site of the recurrence is often undetectable.
Adalsteinn Gunnlaugsson, Vilberg Johannesson, Elinore Wieslander, Eva Brun, Ulrika Bitzén, Olof Ståhl, Ola Bratt, Göran Ahlgren, Tomas Ohlsson, Elisabeth Kjellén, Per Nilsson   +10 more
doaj   +1 more source

Updates of prostate cancer staging: Prostate-specific membrane antigen [PDF]

Investigative and Clinical Urology, 2016
The ability to accurately stage prostate cancer in both the primary and secondary staging setting can have a major impact on management. Until recently radiological staging has relied on computer tomography, magnetic resonance imaging, and nuclear bone
Niranjan J Sathianathen, Alastair Lamb, Rajesh Nair, Nicolas Geurts, Catherine Mitchell, Nathan L Lawrentschuk, Daniel A Moon, Declan G Murphy   +7 more
doaj   +1 more source

Pulmonary tumor embolism in renal cell carcinoma detected by hybrid CT and F18-PSMA PET

Radiology Case Reports, 2023
We present the case of a 75-year-old female in which a pulmonary tumor embolism was detected incidentally on a prostate-specific membrane antigen positron emission tomography-computed tomography restaging scan.
Jared E. Tan, B-BMED, Sai Vishnu, Dalveer Singh, MBBS, FRANZCR   +2 more
doaj   +1 more source

The effects of specific expression of apoptin under the control of PSES and PSA promoter on cell death and apoptosis of LNCaP cells [PDF]

Iranian Journal of Basic Medical Sciences, 2017
Objective(s): Apoptotic effect of apoptin has been demonstrated in numerous studies. However, its tumor specificity has been questioned by some reports.
Vida Mohammadi, Abbas Behzad Behbahani, Gholam Reza Rafiee, Seyed Younes Hosseini, Marzieh Alizadeh Zarei, Mohammad Ali Okhovat, Mohammad Ali Takhshid   +6 more
doaj   +1 more source

Single-lesion Prostate-specific Membrane Antigen Protein Expression (PSMA) and Response to [177Lu]-PSMA-ligand Therapy in Patients with Castration-resistant Prostate Cancer

European Urology Open Science, 2021
Initial reports of a clinical response in patients treated with the radioligand [177Lu]-PSMA-617 for castration-resistant prostate cancer (CRPC) are promising, despite known inter- and intrapatient heterogeneity.
Judith Stangl-Kremser, Sazan Rasul, Jeffrey J. Tosoian, Simpa S. Salami, Alexander Zaslavsky, Aaron Udager, Peter Mazal, Renate Kain, Eva Comperat, Marcus Hacker, Alexander Haug, Markus Mitterhauser, Carmen Pozo-Salido, Christina Steinbach, Melanie R. Hassler, Gero Kramer, Shahrokh F. Shariat, Ganesh S. Palapattu   +17 more
doaj   +1 more source

Optimization of PET protocol and interrater reliability of 18F-PSMA-11 imaging of prostate cancer [PDF]

, 2020
Background Several scan parameters for PET imaging with F-18-PSMA-11 such as dosage, acquisition time and scan duration were evaluated to determine the most appropriate scan protocol, as well as the effect of furosemide administration on lesion ...
Achten, Eric, De Man, Kathia, De Vos, Filip, Kersemans, Ken, Ost, Piet, Piron, Sarah, Schelfhout, Vanessa, Van Laeken, Nick   +7 more
core   +2 more sources

Prostate-specific membrane antigen-based imaging [PDF]

Urologic Oncology: Seminars and Original Investigations, 2013
Prostate cancer (CaP) is the most common noncutaneous malignancy affecting men in North America. Despite significant efforts, conventional imaging of CaP does not contribute to patient management as much as imaging performed for other common cancers. Given the lack of specificity in conventional imaging techniques, one possible solution is to screen ...
Joseph R, Osborne, Naveed H, Akhtar, Shankar, Vallabhajosula, Alok, Anand, Kofi, Deh, Scott T, Tagawa   +5 more
openaire   +2 more sources

Impact of short‐term Dutasteride treatment on prostate‐specific membrane antigen expression in a mouse xenograft model

Cancer Reports, 2021
Background Dutasteride has been shown to increase expression of the prostate‐specific membrane antigen (PSMA) in prostate cancer cells in previous in vitro studies. This 5‐alpha‐reductase inhibitor is commonly used for the treatment of symptomatic benign
Benedikt Kranzbühler, Rosa Sousa, Lukas Prause, Irene A. Burger, Niels J. Rupp, Tullio Sulser, Souzan Salemi, Daniel Eberli   +7 more
doaj   +1 more source

PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) AS DIAGNOSTIC BIOMARKER IN PROSTATE CANCER

Jurnal Urologi Indonesia, 2022
Objective: This study aimed to compare PSMA expression in both prostate cancer and benign prostate disease. Material & Methods: PSMA antigen expression was examined using polymerase chain reaction (PCR), twenty samples from each prostate cancer and ...
Lucky Frannata, Indrawarman Soeroharjo, Raden Danarto, Didik Setyo Heriyanto   +3 more
doaj   +1 more source