Results 191 to 200 of about 1,807,537 (411)
Clusterin knockdown sensitizes prostate cancer cells to taxane by modulating mitosis
EMBO Molecular Medicine, 2016 Clusterin (CLU) is a stress‐activated molecular chaperone that confers treatment resistance to taxanes when highly expressed. While CLU inhibition potentiates activity of taxanes and other anti‐cancer therapies in preclinical models, progression to ...
Nader Al Nakouzi +11 more
doaj +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Sexual well-being and diurnal cortisol after prostate cancer treatment. [PDF]
, 2020 Sexual dysfunction and psychological distress are common after prostate cancer. Research has not examined the role of neuroendocrine markers of stress (e.g. cortisol).
Gaffey, Allison E +4 more
core
THE PRERECTAL CURVILINEAR INCISION FOR PROSTATIC ABSCESS; WITH A REPORT OF THREE CASES [PDF]
, 1902 Joseph Ransohoff
openalex +1 more source
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Effect of Adding Probabilistic Zonal Prior in Deep Learning-based Prostate Cancer Detection [PDF]
arXiv, 2019 We propose and evaluate a novel method for automatically detecting clinically significant prostate cancer (csPCa) in bi-parametric magnetic resonance imaging (bpMRI). Prostate zones play an important role in the assessment of prostate cancer on MRI. We hypothesize that the inclusion of zonal information can improve the performance of a deep learning ...
arxiv