Results 211 to 220 of about 837,272 (256)

DTX3 Suppresses the NPM3–RUVBL1 Axis to Inhibit Homologous Recombination Repair and Abrogate Tumor Radioresistance

Advanced Science, EarlyView.
Deltex 3 (DTX3) catalyzes K27‐linked ubiquitination of nucleophosmin 3 to disrupt homologous recombination repair and reverse tumor radioresistance. Low DTX3 predicts poor survival and radiotherapy recurrence, serving as a radiosensitizing therapeutic target.
Jia‐Hao Xiao, Chang‐Jun Xie, Yan‐Hua Chen, Hao Cheng, Shuang‐Hui Li, Wei Li, Ya‐Wen Bin, Rui‐Min He, Ying‐Qing Li, Ping Feng   +9 more
wiley   +1 more source

Beyond Charge: Field‐Effect Transistors in Multimodal Biosensing Platforms for Biomolecular Interaction Studies

Advanced Electronic Materials, EarlyView.
This review summarizes the developments in field‐effect transistor (FET)‐based dual‐mode sensor platforms and what can be learned from them. It identifies charge as a crucial factor in biomolecular interactions at interfaces, outlines the challenges of hybrid systems, and highlights their benefits.
Roger Hasler, Ciril Reiner‐Rozman, Christoph Kleber, Jakub Dostalek, Wolfgang Knoll   +4 more
wiley   +1 more source

Diagnosis of prostate cancer by multi-modal ultrasound imaging. [PDF]

Medicine (Baltimore)
Li J, He K, Zhang H, Hu D, Wei X, Luo L.
europepmc   +1 more source

Local Recurrence and Oncological Outcomes After Transanal Total Mesorectal Excision With Intersphincteric Resection for Lower Rectal Cancer: A Nationwide Multicenter Cohort Study (Ta‐Ta‐Mi Study)

Annals of Gastroenterological Surgery, EarlyView.
The 3‐year local recurrence (LR), recurrence‐free survival, and overall survival rates were 7.3%, 79.5%, and 98.1%, respectively. Multivariable analysis identified circumferential resection margin (CRM)/radial margin (RM) positivity as an independent risk factor for LR.
Kan Tanabe, Shinichiro Mori, Kenji Baba, Takeru Matsuda, Ichiro Takemasa, Koji Okabayashi, Chikayoshi Tani, Tatsuya Manabe, Yoshihiro Kakeji, Takao Ohtsuka, Seiichiro Yamamoto, Takeshi Naitoh, Ta‐Ta‐Mi Study Group Collaborative of the Japan Society of Laparoscopic Colorectal Surgery   +12 more
wiley   +1 more source

Applying Proteogenomics to Characterize Molecular Features Associated With a High-Risk HOXB13 Gene Variant in Prostate Cancer Tumors. [PDF]

MedComm (2020)
Raspin K, Noor Z, Aref AT, Marthick JR, Jung CH, Donovan S, Williams S, Hains PG, Robinson PJ, Balleine RL, Zhong Q, Reddel RR, FitzGerald LM, Dickinson JL.   +13 more
europepmc   +1 more source

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

Advanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source

Deep learning-assisted needle artifact suppression for enhanced anatomical visualization in prostate high-dose-rate brachytherapy ultrasound imaging. [PDF]

Brachytherapy
Gao Y, Niedermayr T, Dai X, Charyyev S, Xing L, Bagshaw H, Buyyounouski MK.   +6 more
europepmc   +1 more source

Programable Acoustic Single‐Cell Manipulation With Model‐Free Machine Learning

Advanced Intelligent Systems, EarlyView.
Closed‐loop control with ultrasound enables precise, noninvasive manipulation of individual cells inside a microfluidic device using a model‐free reinforcement learning‐inspired algorithm, achieving 2D control using a single piezoelectric transducer.
Alexander Edthofer, Guilherme J. Perticarari, Selma Helvelius Bounja, Thierry Baasch   +3 more
wiley   +1 more source